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RISS 인기검색어
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- 저자 : HIGH 연구자 그룹(HIGH Study Group) (검색결과 1 건)
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고혈압 환자에서 하이자(TM) 정의 안정성과 유효성 평가를 위한 Community - based study
HIGH 연구자 그룹(HIGH Study Group) 대한내과학회 2002 대한내과학회지 Vol.62 No.1
N/A Background: This study was designed to evaluate efficacy and safety of losartan/hydro-chlorothiazide combined tablet (Hyzaar?) under usual practice condition. Methods: In HIGH (Hyzaar? In Group of Hypertensive patients) study, patients diagnosed as hypertension were on losartan (50 mg)/hydrochlorothiazide (12.5 mg) combined tablet (Hyzaar?) once daily for more than 8 weeks. Blood pressure was measured at least twice; prior to administering Hyzaar? and 8 weeks after. Blood pressure at week 4 was also measured when possible. Adverse experience was investigated throughout and 14 days following the treatment. Results: A total of 2428 patient s (male : female=4:6, mean age; 57.5±11.3) were assessed. On week 8 of treatment, systolic blood pressure and diastolic blood pressure measured were 135.3±14.7mmHg, 84.4±9.3mmHg, respectively. These denote 23.1mmHg, 12.4mmHg decrease from the baseline levels, respectively. After 8 weeks of treatment, blood pressure in 79% of patients either reached the goal (SBP<140mmHg and DBP<90mmHg) or was under control (reduction of diastolic blood pressure≥10mmHg). Gender, presence of diabetes mellitus, body mass index and comedication of other antihypertensive agents did not affect the degree of blood pressure reduction by Hyzaar? treatment. Decrease of diastolic blood pressure in younger age groups under 40 and 41-49 years-old were significantly greater compared to that of elderly patients over 70 years-old (p<0.05, p <0.01, respectively). Greater decrease of blood pressure (p <0.001) was seen in patients with higher baseline blood pressure. Clinical adverse experience was seen in 26 patients (1.1%) and any specific adverse experience did not exceed 1%. Conclusion: Treatment of losartan (50 mg)/hydrochlorothiazide (12.5 mg) is highly effective in lowering blood pressure with few adverse experience in hypertension patient s.(Korean J Med 62:25-34, 2002)
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