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HERMAWATI, Adya,ANAM, Choirul,SUWARTA, Suwarta,WARDHANI, Arie Restu Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.8
The objective of this research is to find out the effect of innovative culture and quality of work life on competitive advantage strategy with the mediation of individual performance. This research is the continuance of previous research conducted by Adya Hermawati with an originality aspect emphasizing a concept comprising innovative culture, quality of work life, and individual performance as factors that control competitive advantage strategy. The research subject is Tourism Industry SMEs. Explanatory research is a research method used in this study, by surveying respondents. The data sources in this research are primary and secondary. Primary data is collected from respondents directly through a questionnaire whereas secondary data are obtained from references that are relevant to research problems. In conformity with this explanation, the type of research data is quantitative data. The results of this research show that: innovative culture has an effect on individual performance, quality of work life affects individual performance, innovative culture has an effect on competitive advantage, quality of work life affects competitive advantage, individual performance has an effect on competitive advantage, innovative culture affects competitive advantage with the mediation of individual performance, and quality of work life affects competitive advantage with the mediation of individual performance.
Managing human capital for innovative activities in Indonesian herbal medicine firms
Erman Aminullah,Wati Hermawati,Trina Fizzanty,Qinan M. B. Soesanto 기술경영경제학회 2017 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.25 No.2
This paper attempts to explain human capital enhancement (HCE)practices in upgrading human skills, knowledge and ability,specifically (i) how firms’ internal upgrading mechanisms areimplemented and (ii) how firms enhance human capital throughinteractions with external parties. Through case studies ofIndonesian herbal medicine firms, this study reveals that HCE forinnovative activities in herbal medicine firms occurred throughinnovative learning – by using and interacting. Companies showlearning by using traditional herbal ingredients to redesigninnovative products; managing continuously internal learning byinteracting across functional teams to create new, innovativeproducts; and managing external learning by interacting withexternal parties in the search for new, innovative products. Theeffective use of internal and external sources of innovation iscoordinated by, respectively, top management direction inside thecompany without research and development (R&D); managers ofcross-functional teams within the company with in-house R&Dactivities; and top-level management meetings within thecompany with limited R&D activities.
Dyah Ayu Rachmadhaningtiyas,Leny Heliawati,Elvira Hermawati,Yana Maolana Syah 한국생약학회 2021 Natural Product Sciences Vol.27 No.2
A new cipadesin limonoid, i.e. 3-epi-cipadonoid C (1), and a new tirucallane triterpene, i.e. hispidol B 3-palmitate (3), have been isolated from the seeds and fruit peels extract of Sandoricum koetjape, respectively. Along with these compounds the known limonoid, cipaferen G (2), and two pentacyclic triterpenes, bryonolic (4) and bryononic (5) acids, were also isolated. The strucrures of the new compounds were elucidated by the analysis of NMR and mass spectral data. Compounds 1 - 5 were evaluated as the inhibitor of receptor tyrosine kinases (EGFR, Epidermal Growth Factor Receptor; HER2, HER4, Human Epidermal growth factor Receptor 2, -4; IGFR, Insulin-like Growth Factor Receptor; InsR, Insulin Receptor; KDR, Kinase insert Domain Receptor; PDGFRα, and PDGFRb, Platelet-Derived Growth Factor Receptor-α and -b). The results showed only 1 and 3 that have weak activity against InsR.
Four Dammarane Triterpenes and Their Inhibitory Properties Against Eight Receptor Tyrosine Kinases
Leny Heliawati,Husnul Khatimah,Elvira Hermawati,Yana Maolana Syah 한국생약학회 2020 Natural Product Sciences Vol.26 No.4
In recent years, tyrosine kinases (TKs) have been the target to combat cancers, and most of the developed inhibitors are of synthetic origin. Natural compounds that have the properties as the TK’s inhibitors are very limited. This paper described the isolation of a new dammarane triterpene from the tree bark of Sandoricum koetjape, along with three known related dammaranes from the damar resin of Shorea javanica, as well as their inhibitory properties against eight receptor TKs (RTKs: EGFR, HER2, HER4, IGF1R, InsR, KDR, PDGFRa, and PDGFRb). Based on the NMR and mass spectral data the new compound was identified as (12b,20S)-12,20-dihydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (12b-hydroxydammarenolic acid) (1), while the three known compounds were identified as (20S)-20-hydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (dammarenolic acid) (2), (3b,20S)-3,20-dihydroxydammaran-24-ene (3), and (20S)-3-oxo-20-hydroxydammaran-24-ene (4). The tyrosine kinase assay of the four compounds resulted only 1 and 2 at concentration of 10 mM that had weak activity against EGFR and InsR, with their % inhibitory were 30%, 27% (1), 45%, and 32% (2), respectively. The results suggested that the presence of a linear carboxylic acid group in both compounds could be of significance to the inhibitory properties against the two RTKs.