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Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia
Varga, Matthew G.,Cai, Hui,Waterboer, Tim,Murphy, Gwen,Shimazu, Taichi,Taylor, Phil R.,Qiao, You-Lin,Park, Sue K.,Yoo, Keun-Young,Jee, Sun Ha,Cho, Eo Rin,Kim, Jeongseon,Abnet, Christian C.,Tsugane, Sh Springer-Verlag 2018 Digestive diseases and sciences Vol.63 No.10
The Relationship of Socioeconomic and Behavioral Risk Factors With Trends of Overweight in Korea
Shin, Jin Hee,Dupre, Matthew E.,Ostbye, Truls,Murphy, Gwen,Silberberg, Mina The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.6
Objectives: Previous studies have shown that overweight (including obesity) has increased significantly in Korea in recent decades. However, it remains unclear whether this change has been uniform among all Koreans and to what extent socioeconomic and behavioral factors have contributed to this increase. Methods: Changes in overweight were estimated using data from the 1998, 2001, 2005, 2007-2009, and 2010-2012 Korea National Health and Nutrition Examination Survey (n=55 761). Results: Overweight increased significantly among men but not among women between 1998 and 2012. Changes in socioeconomic and behavioral factors over the time period were not associated with overall trends for both men and women. However, we found significant differences in the prevalence of overweight relative to key risk factors. For men, overweight increased at a significantly greater rate among the non-exercising (predicted probability [PP] from 0.23 to 0.32] and high-calorie (PP from 0.18 to 0.37) groups compared to their active and lower-calorie counterparts, respectively. For women, overweight increased only among the non-exercising (PP from 0.27 to 0.28) and low-income (PP from 0.31 to 0.36) groups during this period. Conclusions: These findings suggest that programs aimed at reducing overweight should target Korean men and women in specific socioeconomic and behavioral risk groups differentially.
The Relationship of Socioeconomic and Behavioral Risk Factors With Trends of Overweight in Korea
Mina Silberberg,Jin Hee Shin,Matthew E. Dupre,Truls Østbye,Gwen Murphy 대한예방의학회 2015 Journal of Preventive Medicine and Public Health Vol.48 No.6
Objectives: Previous studies have shown that overweight (including obesity) has increased significantly in Korea in recent decades. However, it remains unclear whether this change has been uniform among all Koreans and to what extent socioeconomic and behavioral factors have contributed to this increase. Methods: Changes in overweight were estimated using data from the 1998, 2001, 2005, 2007-2009, and 2010-2012 Korea National Health and Nutrition Examination Survey (n=55 761). Results: Overweight increased significantly among men but not among women between 1998 and 2012. Changes in socioeconomic and behavioral factors over the time period were not associated with overall trends for both men and women. However, we found significant differences in the prevalence of overweight relative to key risk factors. For men, overweight increased at a significantly greater rate among the non-exercising (predicted probability [PP] from 0.23 to 0.32] and high-calorie (PP from 0.18 to 0.37) groups compared to their active and lower-calorie counterparts, respectively. For women, overweight increased only among the non-exercising (PP from 0.27 to 0.28) and low-income (PP from 0.31 to 0.36) groups during this period. Conclusions: These findings suggest that programs aimed at reducing overweight should target Korean men and women in specific socioeconomic and behavioral risk groups differentially.
Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer
Epplein, Meira,Butt, Julia,Zhang, Yang,Hendrix, Laura H.,Abnet, Christian C.,Murphy, Gwen,Zheng, Wei,Shu, Xiao-Ou,Tsugane, Shoichiro,Qiao, You-lin,Taylor, Philip R.,Shimazu, Taichi,Yoo, Keun-Young,Par American Association for Cancer Research 2018 Cancer Epidemiology, Biomarkers & Prevention Vol.27 No.12
<P><B>Background:</B></P><P><I>Helicobacter pylori</I> is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously, we developed and replicated serologic <I>H. pylori</I> biomarkers for gastric cancer risk among prospective cohorts in East Asia and now seek to validate the performance of these biomarkers in identifying individuals with premalignant lesions.</P><P><B>Methods:</B></P><P>This cross-sectional study included 1,402 individuals from Linqu County screened by upper endoscopy. <I>H. pylori</I> protein-specific antibody levels were assessed using multiplex serology. Multivariable-adjusted logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for prevalent intestinal metaplasia, indefinite dysplasia, or dysplasia, compared with superficial or mild atrophic gastritis.</P><P><B>Results:</B></P><P>Compared with individuals seronegative to Omp and HP0305, individuals seropositive to both were seven times more likely to have precancerous lesions (OR, 7.43; 95% CI, 5.59–9.88). A classification model for precancerous lesions that includes age, smoking, and seropositivity to <I>H. pylori</I>, Omp, and HP0305 resulted in an area under the curve (AUC) of 0.751 (95% CI, 0.725–0.777), which is significantly better than the same model, including the established gastric cancer risk factor CagA (AUC, 0.718; 95% CI, 0.691–0.746, <I>P</I><SUB>difference</SUB> = 0.0002).</P><P><B>Conclusions:</B></P><P>The present study of prevalent precancerous gastric lesions provides support for two new serum biomarkers of gastric cancer risk, Omp and HP 0305.</P><P><B>Impact:</B></P><P>Our results support further research into the serological biomarkers Omp and HP0305 as possible improvements over the established virulence marker CagA for identifying individuals with precancerous lesions in East Asia.</P>