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Frederic Guillou,Geun-Sik Jo 한국지능정보시스템학회 2012 한국지능정보시스템학회 학술대회논문집 Vol.2012 No.12
Collaborative filtering (CF) is one of the most widespread methods for recommendation approach. It has been used efficiently to help users to find items that they should appreciate, by identifying users that can be characterized as “similar”, using a similarity measure based on items rating data. However, traditional CF approaches have shown limitation occasioned by problems such as sparsity and cold start. This situation can cause a user to stop using a system due to lack of accuracy in produced recommendations. This paper suggests another source of information, item taxonomies, which have become extremely common among recommender systems for products classification in diverse domains. We combine such knowledge with an inference process on the taxonomy hierarchy to propose a new similarity measure, which focuses on improving recommendations under cold-start conditions. Experiments made on the MovieLens dataset indicate that our method improves results when applied to cold start situations.
Ya, Vinh,Guillou, Esther Le,Chen, Yi-Ming,Yu, Jui-Hsuan,Choo, Kwang-Ho,Chuang, Sheng-Ming,Lee, Shou-Jen,Li, Chi-Wang Elsevier 2018 JOURNAL- TAIWAN INSTITUTE OF CHEMICAL ENGINEERS Vol.87 No.-
<P><B>Abstract</B></P> <P>A novel sacrificial anode comprised of scrap iron packed inside a cage made of titanium mesh was developed for Cr(VI) reduction. With electric currents applied, the surface passivation of scrap iron electrode could be avoided. Due to the large surface area with open structures provided, the applied current densities (1.18–3.54 mA/cm<SUP>2</SUP>) were low, resulting in low operating voltage and energy consumption. Complete Cr(VI) removal was achieved with electric currents applied, whereas only 20% of the Cr(VI) was removed without electricity. Direct Cr(VI) reduction on the iron surface was a dominant mechanism for the system operated at low (0.25 A) or no current. Acidic pH levels were more effective in Cr(VI) removal, due to more adsorption of Cr(VI) onto the precipitated Fe hydroxide. The trend in total Cr removal was almost the same as that of Cr(VI) removal, but time required to complete total Cr removal was extended. With intermittent electricity supply at a high electric current intensity, the energy consumption of the system was more efficient. Using scrap iron as a sacrificial anode under the intermittent current condition can save 72–77% of the total operational costs required by the conventional plate electrode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel anode packed with scrap iron inside a Ti mesh was used for reducing Cr(VI). </LI> <LI> Electroplating wastewater containing Cr(VI) and Ni(II) was treated. </LI> <LI> Current intensity and initial pH affect the Cr(VI) reduction pattern significantly. </LI> <LI> Intermittent but high electric current supply saved 72–77% of the operating costs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy
Taveau Nicolas,Cubizolle Aurélie,Guillou Laurent,Pinquier Nicolas,Moine Espérance,Cia David,Kalatzis Vasiliki,Vercauteren Joseph,Durand Thierry,Crauste Céline,Brabet Philippe 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Environmental light has deleterious effects on the outer retina in human retinopathies, such as ABCA4-related Stargardt’s disease and dry age-related macular degeneration. These effects involve carbonyl and oxidative stress, which contribute to retinal cell death and vision loss. Here, we used an albino Abca4−/− mouse model, the outer retina of which shows susceptibility to acute photodamage, to test the protective efficacy of a new polyunsaturated fatty acid lipophenol derivative. Anatomical and functional analyses demonstrated that a single intravenous injection of isopropyl-phloroglucinol-DHA, termed IP-DHA, dose-dependently decreased light-induced photoreceptor degeneration and preserved visual sensitivity. This protective effect persisted for 3 months. IP-DHA did not affect the kinetics of the visual cycle in vivo or the activity of the RPE65 isomerase in vitro. Moreover, IP-DHA administered by oral gavage showed significant protection of photoreceptors against acute light damage. In conclusion, short-term tests in Abca4-deficient mice, following single-dose administration and light exposure, identify IP-DHA as a therapeutic agent for the prevention of retinal degeneration.
Buchon, Nicolas,Poidevin, Mickael,Kwon, Hyun-Mi,Guillou, Auré,lien,Sottas, Valentin,Lee, Bok-Luel,Lemaitre, Bruno National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.30
<P>The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, which are activated by secreted pattern-recognition receptors. Here, we demonstrate the essential role of ModSP, a modular serine protease, in the activation of the Toll pathway by gram-positive bacteria and fungi. Our analysis shows that ModSP integrates signals originating from the circulating recognition molecules GNBP3 and PGRP-SA and connects them to the Grass-SPE-Spätzle extracellular pathway upstream of the Toll receptor. It also reveals the conserved role of modular serine proteases in the activation of insect immune reactions.</P>