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Functional Roles of Long Non-coding RNA in Human Breast Cancer
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Cao, San-Jie,Wen, Xin-Tian,Huang, Yong,Huang, Xiao-Bo,Wu, Rui,Ma, Xiao-Ping,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Pan, Hai-Bo,Zhang, Man-Li,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.
Thermal decomposition kinetics of 5-fluorouracil from thermogravimetric analysis
Yi-ling Bei,Qing-yang Liu,Gui-bin Qi,Yuan-jun Ding 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5
The thermal decomposition kinetics of 5-fluorouracil was studied by thermogravimetric analysis methodology. The decomposition activation energy was calculated by using Ozawa method by means of TGA in nitrogen atmosphere. Moreover, the decomposition mechanism and pre-factor were obtained by Coats-Redfern and Achar methods, respectively. It is found that the decomposition activation energy of fluorouracil is 105 kJ·mol−1. The decomposition mechanisms obtained by Coats-Redfern and Achar methods are G( α)=[−ln(1− α)]2/3 and f( α)=1.5(1− α)[−ln(1−α)]1/3 respectively, lnA is 21.40 min−1.