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RISS 인기검색어
- 검색키워드
- 저자 : Guangzhi Yi (검색결과 2 건)
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Numerical Investigation on a Twin-Screw Multiphase Pump Under low IGVF
Shuaihui Sun,Pengbo Wu,Pengcheng Guo,Guangzhi Yi,Ahmed Kovacevic 한국유체기계학회 2021 International journal of fluid machinery and syste Vol.14 No.4
A three-dimensional transient numerical model was developed to obtain the two-phase flow characteristics in a twin-screw multiphase pump based on dynamic mesh technology and the multiphase flow model. The pump performance under different inlet gas volume fractions (IGVF) was predicted by the numerical model and was tested. Then, the numerical model was validated after comparing the simulation and experimental results. After that, the flow field in the pump under 10% IGVF was analyzed. When the IGVF is 10%, the pressure increases step by step and is symmetrical from both ends to the middle of the screw rotors. The pressure distribution through a single working chamber is uniform. It falls rapidly at the inlet of the tooth tip gap and then drops linearly in the gap channel. At the outlet of the tip gap, the pressure temporarily falls due to the high-speed jet. The GVF distribution in the working chamber is uneven. The leakage flow is laminar in the tip gap, and the liquid concentrates on the top of the gap. When the last working chamber connects with the discharge chamber, the discharge jet flow causes the vortices in the discharge pipe. The gas gradually moves to the center of the vortices, forming four gas-phase aggregation regions. The velocity of the interlobe leakage is the largest. The maximum velocity appears at the second cross-section and reaches 35m/s. This research can be used to improve the performance of the twin-screw multiphase pump under two-phase working conditions.
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A novel M2e-multiple antigenic peptide providing heterologous protection in mice
Feng Wen,Ji-Hong Ma,Hai Yu,Fu-Ru Yang,Meng Huang,Yan-Jun Zhou,Ze-Jun Li,Xiu-Hui Wang,Guo-Xin Li,Yi-Feng Jiang,Wu Tong,Guangzhi Tong 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.1
Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in which novel strains loom. Here, we developed and evaluated a novel M2e-multiple antigenic peptide (M2e-MAP) as a supplemental antigen for inactivated H3N2 vaccine to provide cross-protection against two main subtypes of SwIVs, H1N1 and H3N2. The novel tetra-branched MAP was constructed by fusing four copies of M2e to one copy of foreign T helper cell epitopes. A high-yield reassortant H3N2 virus was generated by plasmid based reverse genetics. The efficacy of the novel H3N2 inactivated vaccines with or without M2e-MAP supplementation was evaluated in a mouse model. M2e-MAP conjugated vaccine induced strong antibody responses in mice. Complete protection against the heterologous swine H1N1 virus was observed in mice vaccinated with M2e-MAP combined vaccine. Moreover, this novel peptide confers protection against lethal challenge of A/Puerto Rico/8/34 (H1N1). Taken together, our results suggest the combined immunization of reassortant inactivated H3N2 vaccine and the novel M2e-MAP provided cross-protection against swine and human viruses and may serve as a promising approach for influenza vaccine development.
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