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- 저자 : Goyal Anil (검색결과 3 건)
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Anil Kumar,Richa Goyal 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
Oxidative stress is a major contributor to the alterations of various pathological conditions, including neurodegenerative and neuropsychiatric problems. Antioxidative flavonoids, ubiquitously included in vegetables, fruits, and teas, are expected to prevent degenerative diseases. Recently, flavonoids have been characterized as neuroprotectants in the treatment of various neurological disorders. The present study was designed to investigate protective effects of quercetin, a bioflavonoid, against acute immobilization-induced behavioral and biochemical alterations in mice. Mice were immobilized for a period of 6 hours. Quercetin (20 and 40 mg/kg, i.p.) was administered 30 minutes before subjecting the animals to acute stress. Behavioral tests (mirror chamber, actophotometer, and tail flick test) and biochemical analysis (malondialdehyde, reduced glutathione, catalase, nitrite, and protein levels) were subsequently performed. Acute immobilization stress for a period of 6 hours caused severe anxiety, analgesia, and impaired motor activity in mice. Biochemical analyses revealed an increase in malondialdehyde and nitrite levels as well as partial depletion of reduced glutathione and catalase activity in immobilization-stressed brain. Behavioral and biochemical parameters were significantly altered as compared to naive mice. Pretreatment with quercetin (20 and 40 mg/kg, i.p.) significantly reversed immobilized stress-induced anxiety and analgesia and reduced locomotor activity. Biochemically, quercetin treatment attenuated malondialdehyde accumulation and nitrite activity and restored the depleted reduced glutathione and catalase activity. Neuroprotective effects of quercetin were significantly improved as compared to control (immobilized stressed) animals. Results suggest that neuroprotective properties of quercetin can be used in the treatment and management of stress and related disorders.
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Dar Bilal Ahmad,Singh Deepak,Goyal Anil,Ahmad Izhar 경남대학교 기초과학연구소 2019 Nonlinear Functional Analysis and Applications Vol.24 No.3
This work is devoted to study some Ostrowski type inequalities for generalized Hukukara differentiable interval valued functions. Mean valued theorem for gH-differentiable interval valued functions is also derived. Established results generalize some pioneer results in the existing state-of-art. Moreover, error estimations to quadrature rule of Riemann type, Simpson type and Trapezoidal type are obtained for interval valued functions by the application of one of the derived inequality. In addition an illustrative example is also furnished which demonstrates the viability of the hypothesis of one of our results.
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ON APPLICATIONS OF GENERALIZED F-CONTRACTION TO DIFFERENTIAL EQUATIONS
Younis Mudasir,Singh Deepak,Gopal Dhananjay,Goyal Anil,Rathore Mahendra Singh 경남대학교 기초과학연구소 2019 Nonlinear Functional Analysis and Applications Vol.24 No.1
In the present work, we introduce the new concept of a generalization of Ger- aghty type F-Berinde contraction mappings and establish certain existence results for such mappings. Some examples will embellish the results, for the same computer simulation is done. Our examples involve a series of complicated structured functions which cannot be treated by classical fixed point methods. Our findings extend, unify and enrich a multitude results in the existing literature. As an application, we apply our abstract results to establish the existence of solution of differential equations of first and second order to exhibit the po- tency and viability of our results. At the end, as an open problem, we suggest storekeeper’s control problem in terms of Volterra integral equation whose solution may be procured from the established results.
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