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Lycopene Partially Reverses Symptoms of Diabetes in Rats with Streptozotocin-Induced Diabetes
Aysegul Bayramoglu,Gokhan Bayramoglu,Hakan Senturk 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.2
In the present study, we describe the effects of lycopene on the symptoms of streptozotocin (STZ)–induced diabetes in rats. Lycopene at the dose of 2.5 mg/kg body weight (bw) per day was orally administered to STZ-induced diabetic rats for a period of 7 days after onset of diabetes. At the same time, food–water intake and body weight change were recorded daily. Upon sacrifice, biochemical parameters, such as the serum glucose, insulin, total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were measured in all experimental groups. Administration of lycopene at the dose of 2.5 mg/kg bw per day significantly reduced serum glucose, TC, TG, ALT, and AST levels, and increased serum insulin levels, but there were no improvements in food–water intake and body weight change parameters in lycopene-treated diabetic rats. The results suggest that orally administrated lycopene exhibits a potent hypoglycemic effect in STZ-induced diabetic rats and that lycopene may be useful for the management of diabetes mellitus.
Mustafa Yamac,Gungor Kanbak,Melih Zeytinoglu,Gokhan Bayramoglu,Hakan Senturk,Mustafa Uyanoglu 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50–150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal, STZ-induced diabetic, and EPS-treated diabetic rats. Following oral administration of EPS dosages for 7 days, the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS, at the dose of 150 mg/kg, exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P < .05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans.