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- 저자 : Gerardo Escalona-Cardoso (검색결과 2 건)
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Spirulina (Arthrospira) Protects Against Valproic Acid–Induced Neural Tube Defects in Mice
Gerardo N. Escalona-Cardoso,Norma Paniagua-Castro,Ricardo Pe´rez-Paste´n,Germa´n Chamorro-Cevallos 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.12
Valproic acid (VPA) is a potent inducer of neural tube defects in human and mouse, its teratogenicity is associated with its potential to generation of free radicals and increase oxidative stress. Furthermore, spirulina (SP) has shown pharmacological properties against teratogenicity, which are attributed to its antioxidant potential. Accordingly, the present study was performed to investigate the influence of SP on the teratogenicity of VPA in imprinting control region mice and the possible mechanisms of action. VPA (sodium valproate) was administered intraperitoneally to mice on gestation day (GD) 8 at a dose of 600 mg/kg. SP was given orally at 125, 250, and 500 mg/kg daily from GD0 through GD18. The most common finding in fetuses with VPA exposure was exencephaly. SP decreased the incidence of this and other malformations and increased levels of superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, these results illustrate the protective action of SP through its antioxidant activity against VPA-induced teratogenicity.
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Spirulina (Arthrospira) Protects Against Cadmium-Induced Teratogenic Damage in Mice
Norma Paniagua-Castro,Gerardo Escalona-Cardoso,Dolores Hernández-Navarro,Ricardo Pérez-Pastén,Germán Chamorro-Cevallos 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.4
The role of Spirulina (Arthrospira) in preventing cadmium (Cd) teratogenicity in ICR mice was studied. Cd was administered intraperitoneally to female mice at 1.5 mg/kg on gestation day (GD)-7, and Spirulina was given by peroral (intragastric) administration at 62.5, 125, 250, or 500 mg/kg from GD-0 through GD-17 (the day when animals were sacrificed). Because among the mechanisms suggested to account for reproductive damage are oxidative stress and lipoperoxidation, embryonic hydroperoxides were also determined. Treatment with Spirulina at the three highest doses significantly decreased the frequency of fetuses with exencephaly, micrognathia, and skeletal abnormalities induced by Cd. Furthermore, Spirulina treatment significantly and dose-dependently decreased lipid peroxidation, which was dramatically increased by administration of the metal. The results of the present study clearly point to the therapeutic potential of Spirulina in Cd-induced teratogenicity and probably through its antioxidant activity.
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