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Orosz, Erzsé,bet,Antal, Ká,roly,Gazdag, Zoltá,n,Szabó,, Zsuzsa,Han, Kap-Hoon,Yu, Jae-Hyuk,Pó,csi, Istvá,n,Emri, Tamá,s Hindawi 2017 International journal of genomics Vol.2017 No.-
<P>To better understand the molecular functions of the master stress-response regulator AtfA in <I>Aspergillus nidulans</I>, transcriptomic analyses of the <I>atfA</I> null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), <I>t</I>-butylhydroperoxide- and diamide-induced oxidative stresses were performed. Several elements of oxidative stress response were differentially expressed. Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence. To elucidate the potential global regulatory role of AtfA governing expression of a high number of genes with very versatile biological functions, we devised a model based on the comprehensive transcriptomic data. Our model suggests that an important function of AtfA is to modulate the transduction of stress signals. Although it may regulate directly only a limited number of genes, these include elements of the signaling network, for example, members of the two-component signal transduction systems. AtfA acts in a stress-specific manner, which may increase further the number and diversity of AtfA-dependent genes. Our model sheds light on the versatility of the physiological functions of AtfA and its orthologs in fungi.</P>
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