http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Gary D. Stoner (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Suppression of iNOS Expression by Phlorotannins in Chronic Exposure of Skin to UVB Radiation
Hyejeong Hwang,Tong Chen,Gary D. Stoner,Kyun-Bok Lee,Yung-Choon Yoo,Hyeon-Cheol Shin 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.4
Nitric oxide (NO), endogenously produced by NO synthase (NOS), is an important regulatory molecule for immune response and cytotoxicity. Up-regulation of inducible NOS (iNOS) and increased NO production occur in many pathological conditions associated with inflammation. Multiple exposures to solar ultraviolet (UV) radiation cause critical damages that may lead to development of several cutaneous disorders including skin cancer. In this study, we assessed the inhibitory effects of polyphenols extracted from brown algae, phlorotannins, on UVB-induced iNOS gene expression using SKH-1 hairless mouse model. The mice were treated orally with phlorotannins (0.1% and 0.5% with diet, w/w) and topically (3 ㎎ and 6 ㎎/0.2 ㎖ of solvent per mouse) and irradiated with UVB (160 mJ/㎠) three times per week for 26 weeks. Dietary feeding of 0.1% and 0.5% phlorotannins remarkably reduced iNOS gene expression by 73% and 88%, respectively (p < 0.05). Topical treatment of 3 ㎎ and 6 ㎎ phlorotannins also showed a significant decrease in iNOS induction by 79% and 94%, respectively (p < 0.05). These observations demonstrate that dietary feeding and topical application of phlorotannins afford strong protection against UVB-induced iNOS suppression and inflammatory damage in the skin. Furthermore, the results of this study suggest phlorotannins may be useful as a preventive agent against inflammatory responses associated with photocarcinogenesis and other adverse effects of UVB exposure.
-
John F. Lechner,Li-Shu Wang,Claudio M. Rocha,Bethany Larue,Cassandra Henry,Colleen M. McIntyre,Kenneth M. Riedl,Steven J. Schwartz,Gary D. Stoner 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
This study was undertaken to determine if the oral consumption of red beetroot food color would result in an inhibition of N-nitrosomethylbenzylamine (NMBA)-induced tumors in the rat esophagus. Rats were treated with NMBA and given either regular water ad libitum or water containing 78μg/mL commercial red beetroot dye, E162. The number of NMBA-induced esophageal papillomas was reduced by 45% (P<.001) in animals that received the food color compared to controls. The treatment also resulted in reduced rates of cell proliferation in both precancerous esophageal lesions and in papillomas of NMBA-treated rats, as measured by immunohistochemical staining of Ki-67 in esophageal tissue specimens. The effects of beetroot food color on angiogenesis (microvessel density by CD34 immunostaining), inflammation (by CD45 immunostaining), and apoptosis (by terminal deoxynucleotidyl transferase dUTP nick end-labeling staining) in esophageal tissue specimens were also determined. Compared to rats treated with NMBA only, the levels of angiogenesis and inflammation in the beetroot color-consuming animals were reduced, and the apoptotic rate was increased. Thus, the mechanism(s) of chemoprevention by the active constituents of red beetroot color include reducing cell proliferation, angiogenesis, and inflammation and stimulating apoptosis. Importantly, consumption of the dye in the drinking water for a period of 35 weeks did not appear to induce any overt toxicity. Based on the fact that red beetroot color contains betanins, which have strong antioxidant activity, it is postulated that these effects are mediated through inhibition of oxygen radical-induced signal transduction. However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
