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Established and Emerging Therapies in Acute Spinal Cord Injury
Ron Gadot,David N. Smith,Marc Prablek,Joey K. Grochmal,Alfonso Fuentes,Alexander E. Ropper 대한척추신경외과학회 2022 Neurospine Vol.19 No.2
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and imaging, patients who are deemed surgical candidates should undergo decompression with stabilization. Earlier intervention can improve neurological recovery in the post-operative period while allowing earlier mobilization. Optimized medical management is paramount to improve outcomes. Emerging strategies for managing SCI in the acute period stem from an evolving understanding of the pathophysiology of the injury. General areas of focus include ischemia prevention, reduction of secondary injury due to inflammation, modulation of the cytotoxic and immune response, and promotion of cellular regeneration. In this article, we review established, emerging, and novel experimental therapies. Continued translational research on these methods will improve the feasibility of bench-to-bedside innovations in treating patients with acute SCI.
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GLOBULAR CLUSTER POPULATIONS: RESULTS INCLUDING S<sup>4</sup>G LATE-TYPE GALAXIES
Zaritsky, Dennis,McCabe, Kelsey,Aravena, Manuel,Athanassoula, E.,Bosma, Albert,Comeró,n, Sé,bastien,Courtois, Helene M.,Elmegreen, Bruce G.,Elmegreen, Debra M.,Erroz-Ferrer, Santiago,Gadot American Astronomical Society 2016 The Astrophysical journal Vol.818 No.1
<P>Using 3.6 and 4.5 mu m images of 73 late-type, edge-on galaxies from the S(4)G survey, we compare the richness of the globular cluster populations of these galaxies to those of early-type galaxies that we measured previously. In general, the galaxies presented here fill in the distribution for galaxies with lower stellar mass, M-*, specifically log(M-*/M-circle dot) < 10, overlap the results for early-type galaxies of similar masses, and, by doing so, strengthen the case for a dependence of the number of globular clusters per 10(9)M(circle dot) of galaxy stellar mass, T-N, on M-*. For 8.5 < log(M-*/M-circle dot) < 10.5 we find the relationship can be satisfactorily described as T-N = (M-*/10(6.7))(-0.56) M-* is expressed in solar masses. The functional form of the relationship is only weakly constrained, and extrapolation outside this range is not advised. Our late-type galaxies, in contrast to our early types, do not show the tendency for low-mass galaxies to split into two T-N families. Using these results and a galaxy stellar mass function from the literature, we calculate that, in a volume-limited, local universe sample, clusters are most likely to be found around fairly massive galaxies (M-* similar to 10(10.8)M(circle dot)) and present a fitting function for the volume number density of clusters as a function of parent-galaxy stellar mass. We find no correlation between T-N and large-scale environment, but we do find a tendency for galaxies of fixed M-* to have larger T-N if they have converted a larger proportion of their baryons into stars.</P>
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