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Gabriela G. Machado,Américo Campos Filho,Paula M. Lazzari,Bruna M. Lazzari,Alexandre R. Pacheco 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.2
The design of segmental bridges, a structure that typically employs precast prestressed concrete elements and the balanced cantilever construction method for the deck, may demand a highly complex structural analysis for increased precision of the results. This work presents a comprehensive numerical analysis of a 3D finite element model using the software ANSYS, version 21.2, to simulate the constructive deck stages of the New Guaiba Bridge, a structure located in Porto Alegre city, southern Brazil. The materials concrete and steel were considered viscoelastic. The concrete used a Generalized Kelvin model, with subroutines written in FORTRAN and added to the main model through the customization tool UPF (User Programmable Features). The steel prestressing tendons used a Generalized Maxwell model available in ANSYS. The balanced cantilever constructive steps of a span of the New Guaiba Bridge were then numerically simulated to follow the actual constructive sequence of the bridge. A comparison between the results obtained with the numerical model and the actual vertical displacement data monitored during the bridge's construction was carried out, showing a good correlation.
Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Izabela G. Barbosa,Gabriela Neves Vaz,Natalia Pessoa Rocha,Rodrigo Machado-Vieira,Marcio Rogerio Diniz Ventura,Rodrigo B. Huguet,Moises E. Bauer,MIchael Berk,Antônio L. Teixeira 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.