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White, H,Deprez, L,Corbisier, P,Hall, V,Lin, F,Mazoua, S,Trapmann, S,Aggerholm, A,Andrikovics, H,Akiki, S,Barbany, G,Boeckx, N,Bench, A,Catherwood, M,Cayuela, J-M,Chudleigh, S,Clench, T,Colomer, D,Dar Nature Publishing Group 2015 Leukemia Vol.29 No.2
<P>Serial quantification of <I>BCR–ABL1</I> mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of <I>BCR–ABL1</I> (e14a2 mRNA fusion)<I>, BCR</I> and <I>GUSB</I> transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 10<SUP>6</SUP>, 1.08±0.11 × 10<SUP>5</SUP>, 1.03±0.10 × 10<SUP>4</SUP>, 1.02±0.09 × 10<SUP>3</SUP>, 1.04±0.10 × 10<SUP>2</SUP> and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 <I>BCR–ABL1</I> testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 <I>BCR–ABL1</I> and three control genes (<I>ABL1, BCR</I> and <I>GUSB</I>). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (https://ec.europa.eu/jrc/en/reference-materials/catalogue/; CRM code ERM-AD623a-f).</P>
White, J S,Forgan, E M,Laver, M,Hä,fliger, P S,Khasanov, R,Cubitt, R,Dewhurst, C D,Park, M-S,Jang, D-J,Lee, H-G,Lee, S-I IOP Pub 2008 Journal of physics, an Institute of Physics journa Vol.20 No.10
<P>We report on the first small-angle neutron scattering measurements from the flux line lattice (FLL) in the high-<I>T</I><SUB>c</SUB> cuprate superconductor Sr<SUB>0.9</SUB>La<SUB>0.1</SUB>CuO<SUB>2</SUB>. Using a polycrystalline sample, the scattered intensity decreases monotonically with scattering angle away from the undiffracted beam, independently of the azimuthal angle around the beam. The absence of clear peaks in the intensity suggests the establishment of a highly disordered FLL within the grains. We find that the intensity distribution may be represented by the form factor for a single flux line in the London approximation, with some contribution from crystal anisotropy. Most interestingly however, we find that, over the observed field range, the temperature dependence of the diffracted intensity is best represented by s-wave pairing, with lower limits of the gap values being very similar to the Bardeen–Cooper–Schrieffer value of Δ(0) = 1.76<I> k</I><SUB>B</SUB><I>T</I><SUB>c</SUB>. However, a qualitative consideration of corrections to the observed intensity suggests that these gap values are likely to be higher, implying strong-coupling behaviour.</P>
White, G. R.,Ainsworth, R.,Akagi, T.,Alabau-Gonzalvo, J.,Angal-Kalinin, D.,Araki, S.,Aryshev, A.,Bai, S.,Bambade, P.,Bett, D. R.,Blair, G.,Blanch, C.,Blanco, O.,Blaskovic-Kraljevic, N.,Bolzon, B.,Boog American Physical Society 2014 Physical Review Letters Vol.112 No.3
<P>A novel scheme for the focusing of high-energy leptons in future linear colliders was proposed in 2001 [P. Raimondi and A. Seryi, Phys. Rev. Lett. 86, 3779 (2001)]. This scheme has many advantageous properties over previously studied focusing schemes, including being significantly shorter for a given energy and having a significantly better energy bandwidth. Experimental results from the ATF2 accelerator at KEK are presented that validate the operating principle of such a scheme by demonstrating the demagnification of a 1.3 GeV electron beam down to below 65 nm in height using an energy-scaled version of the compact focusing optics designed for the ILC collider.</P>
Multiferroicity in the generic easy-plane triangular lattice antiferromagnet RbFe(MoO4)2
White, J. S.,Niedermayer, Ch.,Gasparovic, G.,Broholm, C.,Park, J. M. S.,Shapiro, A. Ya.,Demianets, L. A.,Kenzelmann, M. American Physical Society 2013 Physical review. B, Condensed matter and materials Vol.88 No.6
Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology
Ross, G. Webster,Abbott, Robert D.,Petrovitch, Helen,Duda, John E.,Tanner, Caroline M.,Zarow, Chris,Uyehara‐,Lock, Jane H.,Masaki, Kamal H.,Launer, Lenore J.,Studabaker, William B.,White, Lon R. John Wiley Sons, Inc. 2019 Movement disorders Vol.34 No.2
<P><B>ABSTRACT</B></P><P><B>Background</B></P><P>Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu‐Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively used in Hawaii, may be especially important. This was a cross sectional analysis to evaluate the association of heptachlor epoxide and other organochlorine compounds with Lewy pathology in an expanded survey of brain organochlorine residues from the longitudinal Honolulu‐Asia Aging Study.</P><P><B>Methods</B></P><P>Organochlorines were measured in frozen occipital or temporal lobes in 705 brains using gas chromatography with mass spectrometry. Lewy pathology was identified using hematoxylin and eosin‐ and α‐synuclein immunochemistry‐stained sections from multiple brain regions.</P><P><B>Results</B></P><P>The prevalence of Lewy pathology was nearly doubled in the presence versus the absence of heptachlor epoxide (30.1% versus 16.3%, <I>P</I> < 0.001). Although associations with other compounds were weaker, hexachlorobenzene (<I>P</I> = 0.003) and α‐chlordane (<I>P</I> = 0.007) were also related to Lewy pathology. Most of the latter associations, however, were a result of confounding from heptachlor epoxide. Neither compound was significantly related to Lewy pathology after adjustment for heptachlor epoxide. In contrast, the association of heptachlor epoxide with Lewy pathology remained significant after adjustments for hexachlorobenzene (<I>P</I> = 0.013) or α‐chlordane (<I>P</I> = 0.005). Findings were unchanged after removal of cases of PD and adjustment for age and other characteristics.</P><P><B>Conclusions</B></P><P>Organochlorine pesticides are associated with the presence of Lewy pathology in the brain, even after exclusion of PD cases. Although most of the association is through heptachlor epoxide, the role of other organochlorine compounds is in need of clarification. © 2018 International Parkinson and Movement Disorder Society</P>
The North Ecliptic Pole Wide survey of AKARI: a near- and mid-infrared source catalog
Kim, S. J.,Lee, H. M.,Matsuhara, H.,Wada, T.,Oyabu, S.,Im, M.,Jeon, Y.,Kang, E.,Ko, J.,Lee, M. G.,Takagi, T.,Pearson, C.,White, G. J.,Jeong, W.-S.,Serjeant, S.,Nakagawa, T.,Ohyama, Y.,Goto, T.,Takeuch EDP Sciences 2012 Astronomy and astrophysics Vol.548 No.-
Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy
Monsanto, Megan M.,White, Kevin S.,Kim, Taeyong,Wang, Bingyan J.,Fisher, Kristina,Ilves, Kelli,Khalafalla, Farid G.,Casillas, Alexandria,Broughton, Kathleen,Mohsin, Sadia,Dembitsky, Walter P.,Sussman, Grune & Stratton 2017 Circulation research Vol.121 No.2
<P><B><U>Rationale:</U></B></P><P>The relative actions and synergism between distinct myocardial-derived stem cell populations remain obscure. Ongoing debates on optimal cell population(s) for treatment of heart failure prompted implementation of a protocol for isolation of multiple stem cell populations from a single myocardial tissue sample to develop new insights for achieving myocardial regeneration.</P><P><B><U>Objective:</U></B></P><P>Establish a robust cardiac stem cell isolation and culture protocol to consistently generate 3 distinct stem cell populations from a single human heart biopsy.</P><P><B><U>Methods and Results:</U></B></P><P>Isolation of 3 endogenous cardiac stem cell populations was performed from human heart samples routinely discarded during implantation of a left ventricular assist device. Tissue explants were mechanically minced into 1 mm<SUP>3</SUP> pieces to minimize time exposure to collagenase digestion and preserve cell viability. Centrifugation removes large cardiomyocytes and tissue debris producing a single cell suspension that is sorted using magnetic-activated cell sorting technology. Initial sorting is based on tyrosine-protein kinase Kit (c-Kit) expression that enriches for 2 c-Kit<SUP>+</SUP> cell populations yielding a mixture of cardiac progenitor cells and endothelial progenitor cells. Flowthrough c-Kit<SUP>−</SUP> mesenchymal stem cells are positively selected by surface expression of markers CD90 and CD105. After 1 week of culture, the c-Kit<SUP>+</SUP> population is further enriched by selection for a CD133<SUP>+</SUP> endothelial progenitor cell population. Persistence of respective cell surface markers in vitro is confirmed both by flow cytometry and immunocytochemistry.</P><P><B><U>Conclusions:</U></B></P><P>Three distinct cardiac cell populations with individualized phenotypic properties consistent with cardiac progenitor cells, endothelial progenitor cells, and mesenchymal stem cells can be successfully concurrently isolated and expanded from a single tissue sample derived from human heart failure patients.</P>
A MULTI-WAVELENGTH VIEW OF GALAXY EVOLUTION WITH AKARI
Serjeant, S.,Pearson, C.,White, G.J.,Smith, M.W.L.,Doi, Y. The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
AKARI's all-sky survey resolves the far-infrared emission in many thousands of nearby galaxies, providing essential local benchmarks against which the evolution of high-redshift populations can be measured. This review presents some recent results in the resolved galaxy populations, covering some well-known nearby targets, as well as samples from major legacy surveys such as the Herschel Reference Survey and the JCMT Nearby Galaxies Survey. This review also discusses the prospects for higher redshifts surveys, including strong gravitational lens clusters and the AKARI NEP field.
The AKARI NEP-Deep survey: a mid-infrared source catalogue
Takagi, T.,Matsuhara, H.,Goto, T.,Hanami, H.,Im, M.,Imai, K.,Ishigaki, T.,Lee, H. M.,Lee, M. G.,Malkan, M.,Ohyama, Y.,Oyabu, S.,Pearson, C. P.,Serjeant, S.,Wada, T.,White, G. J. Springer-Verlag 2012 Astronomy and astrophysics Vol.537 No.-
<P>We present a new catalogue of mid-IR sources using the AKARI NEP-Deep survey. The InfraRed Camera (IRC) onboard AKARI has a comprehensive mid-IR wavelength coverage with 9 photometric bands at 2–24?µm. We utilized all of these bands to cover a nearly circular area adjacent to the north ecliptic pole (NEP). We designed the catalogue to include most of sources detected in 7, 9, 11, 15 and 18?µm bands, and found 7284 sources in a 0.67?deg<SUP>2</SUP> area. From our simulations, we estimate that the catalogue is~80 per cent complete to 200µJy at 15–18µm, and ~10 per cent of sources are missed, owing to source blending. Star-galaxy separation is conducted using only AKARI photometry, as a result of which 10 per cent of catalogued sources are found to be stars. The number counts at 11, 15, 18, and 24µm are presented for both stars and galaxies. A drastic increase in the source density is found in between 11 and 15µm at the flux level of~300micro;Jy. This is likely due to the redshifted PAH emission at 8µm, given our rough estimate of redshifts from an AKARI colour–colour plot. Along with the mid-IR source catalogue, we present optical-NIR photometry for sources falling inside a Subaru/Sprime-cam image covering part of the AKARI NEP-Deep field, which is deep enough to detect most of AKARI mid-IR sources, and useful to study optical characteristics of a complete mid-IR source sample.</P>