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Migraine-Associated Otalgia: An Underappreciated Entity
Sussman Sarah,Zimmerman Zachary,Chishom Taylor,Reid Lauren,Seyyedi Mohammad 대한청각학회 2022 Journal of Audiology & Otology Vol.26 No.2
Background and Objectives: Otalgia can be primary/otogenic or secondary as a referred pain from another site, which can be difficult to establish owing to various causes and the complex innervation of the ear. In our center, we observed a large group of patients with unexplained otalgia that had a higher prevalence of migraine. We hypothesized that migraine may cause secondary otalgia. This study then aimed to determine the prevalence of migraine-associated otalgia and evaluate the efficacy of migraine treatment.Subjects and Methods: This 2-year retrospective study was conducted at a busy otology clinic. Patients were identified using diagnostic codes corresponding to otalgia. The prevalence of migraine-associated otalgia was determined, and the efficacy of migraine treatment was evaluated in these patients. The interventions included prophylactic and abortive migraine treatments. Statistical analysis was conducted to compare between the pre- and post-treatment symptoms.Results: A total of 208 patients with otalgia were identified. Sixty-four out of ninety patients with unexplained otalgia met the criteria for migraine; of them, 30 patients had an adequate follow-up and were thus included in the evaluation of treatment efficacy. Otalgia improved in 87% of the patients who received migraine treatment. After treatment, the mean pain score and headache frequency significantly decreased from 7 to 2 and from 27 to 9 days per month, respectively (p<0.001).Conclusions: Migraine should be considered as a source of secondary otalgia, and patients should receive treatment as they often respond to migraine treatment.
Contagion and Capital Market Integration in Asia: Historical and Contemporary Evidence
Nathan Sussman,Yishay Yafeh 서울대학교 경제연구소 1999 Seoul journal of economics Vol.12 No.4
We compare sovereign debt yields in the nineteenth century and today. Using data on nineteenth century Japanese government bonds, and on Korean sovereign debt today we show that foreign investors both then and now use summary indicators to evaluate country risk (the Gold Standard then, IMF packages today). However, "contagion" today is more common than in the past. Events in nineteenth century China hardly caused fluctuations in Japanese yields although capital markets were highly integrated. By contrast, minor events in Asia or Latin America had significant effects on Korean yields in recent years.
Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
Gregory Vurture,Benoit Peyronnet,Jose-Alberto Palma,Rachael D. Sussman,Dominique R. Malacarne,Andrew Feigin,Ricardo Palmerola,Nirit Rosenblum,Steven Frucht,Horacio Kaufmann,Victor W. Nitti,Benjamin M. 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.3
Purpose: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. Methods: We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only patients who complained of overactive bladder (OAB) symptoms and underwent a video-urodynamic study for these symptoms were included. We excluded patients with neurological disorders other than PD and patients with voiding LUTS but without OAB symptoms. Results: We included 42 patients (29 men, 13 women, 74.5±8.1 years old). Seven patients (16.7%) had a postvoid residual (PVR) bladder volume >100 mL and only one reported incomplete bladder emptying. Detrusor overactivity (DO) was found in all 42 patients (100%) and was terminal in 19 (45.2%) and phasic in 22 patients (52.4%). Eighteen patients had detrusor underactivity (DU) (42.3%). Later age of PD diagnosis was the only parameter associated with DU (P=0.02). Patients with bladder outlet obstruction (BOO) were younger than patients without BOO (70.1 years vs. 76.5 years, P=0.004), had later first sensation of bladder filling (173.5 mL vs. 120.3 mL, P=0.02) and first involuntary detrusor contraction (226.4 mL vs. 130.4 mL, P=0.009). Conclusions: DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients.