http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Structural and Functional Analysis of a β<sub>2</sub>-Adrenergic Receptor Complex with GRK5
Komolov, Konstantin E.,Du, Yang,Duc, Nguyen Minh,Betz, Robin M.,Rodrigues, Joã,o P.G.L.M.,Leib, Ryan D.,Patra, Dhabaleswar,Skiniotis, Georgios,Adams, Christopher M.,Dror, Ron O.,Chung, Ka Young Cell Press 2017 Cell Vol. No.
<P><B>Summary</B></P> <P>The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent years, the molecular architecture of a GPCR/GRK complex remains poorly defined. We used a comprehensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), electron microscopy, mutagenesis, molecular dynamics simulations, and computational docking to analyze GRK5 interaction with the β<SUB>2</SUB>-adrenergic receptor (β<SUB>2</SUB>AR). These studies revealed a dynamic mechanism of complex formation that involves large conformational changes in the GRK5 RH/catalytic domain interface upon receptor binding. These changes facilitate contacts between intracellular loops 2 and 3 and the C terminus of the β<SUB>2</SUB>AR with the GRK5 RH bundle subdomain, membrane-binding surface, and kinase catalytic cleft, respectively. These studies significantly contribute to our understanding of the mechanism by which GRKs regulate the function of activated GPCRs.</P> <P><B>PaperClip</B></P> <P>Display Omitted</P> <P><B>Highlights</B></P> <P> <UL> <LI> GRK5-β<SUB>2</SUB>AR binding is enhanced by receptor and kinase ligands and acidic lipids </LI> <LI> GRK5 binding to the β<SUB>2</SUB>AR involves a multi-site interaction </LI> <LI> Receptor binding triggers substantial conformational changes in GRK5 </LI> <LI> RH/catalytic domain separation in GRK5 is essential for receptor phosphorylation </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Graphene-based materials and structures for energy harvesting with fluids – A review
Tarelho, Joã,o P.G.,Soares dos Santos, Marco P.,Ferreira, Jorge A.F.,Ramos, A.,Kopyl, Svitlana,Kim, Sang Ouk,Hong, Seungbum,Kholkin, Andrei Elsevier 2018 Materials today Vol.21 No.10
<P><B>Abstract</B></P> <P>Graphene and graphene-based systems have recently been recognized as promising platforms for energy harvesting, microelectronic components and energy storage owing to their excellent electrical and thermal conductivity, outstanding mechanical properties, good chemical stability, area adaptability, among other significant properties. Integration of energy harvesting systems relying on the graphene/graphene-based materials in contact with fluids has been emphasized in recent years, as well as their potential impact on electric energy generation for a wide range of applications (e.g. innovative medical devices, advanced electronic systems and highly-efficient transduction systems for renewable energy). This review summarizes, for the first time, major breakthroughs carried out in the scope of energy harvesting exploiting graphene-based material systems (comprising graphene films, graphene grids, graphene membranes, 3D graphene composites and tribological structures) in contact with ionic and non-ionic fluids. Several transduction mechanisms for energy harvesting have been thoroughly analyzed. Energy outputs, materials and structures, substrates, types of fluid, manufacture methodologies, and experimental test methodologies are systematically highlighted in this review. Finally, future research directions and innovative applications of these harvesters are proposed.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
A lower hybrid current drive system for ITER
Hoang, G.T.,Bé,coulet, A.,Jacquinot, J.,Artaud, J.F.,Bae, Y.S.,Beaumont, B.,Belo, J.H.,Berger-By, G.,Bizarro, Joã,o P.S.,Bonoli, P.,Cho, M.H.,Decker, J.,Delpech, L.,Ekedahl, A.,Garcia, J. International Atomic Energy Agency 2009 Nuclear fusion Vol.49 No.7
<P>A 20 MW/5 GHz lower hybrid current drive (LHCD) system was initially due to be commissioned and used for the second mission of ITER, i.e. the <I>Q</I> = 5 steady state target. Though not part of the currently planned procurement phase, it is now under consideration for an earlier delivery. In this paper, both physics and technology conceptual designs are reviewed. Furthermore, an appropriate work plan is also developed. This work plan for design, R&D, procurement and installation of a 20 MW LHCD system on ITER follows the ITER Scientific and Technical Advisory Committee (STAC) T13-05 task instructions. It gives more details on the various scientific and technical implications of the system, without presuming on any work or procurement sharing amongst the possible ITER partners. This document does not commit the Institutions or Domestic Agencies of the various authors in that respect.</P>
Cross section data sets for electron collisions with H2, O2, CO, CO2, N2O and H2O
Anzai, K.,Kato, H.,Hoshino, M.,Tanaka, H.,Itikawa, Y.,Campbell, L.,Brunger, M. J.,Buckman, S. J.,Cho, H.,Blanco, F.,Garcia, G.,Limã,o-Vieira, P.,Ingó,lfsson, O. Springer-Verlag 2012 European Physical Journal D Vol.66 No.2