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Ahmed, Attique,Channar, Pervaiz Ali,Saeed, Aamer,Kalesse, Markus,Kazi, Mehar Ali,Larik, Fayaz Ali,Abbas, Qamar,Hassan, Mubashir,Raza, Hussain,Seo, Sung-Yum Elsevier 2019 Bioorganic chemistry Vol.86 No.-
<P><B>Abstract</B></P> <P>Selective inhibition of carbonic anhydrase (CA) enzyme is an active area of research for medicinal chemists. In the current account, a hybrid pharmacophore approach was employed to design sulfonamide, amide and amine containing new series of potent carbonic anhydrase II inhibitors. The aromatic fragment associated with pharmacophore was altered suitably in order to find effective inhibitors of CA-II. All the derivatives <B>4a-4m</B> showed better inhibition compared to the standard acetazolamide. In particular, compound <B>4l</B> exhibited significant inhibition with IC<SUB>50</SUB> value of 0.01796 ± 0.00036 µM. The chemo-informatics analysis justified that all the designed compounds possess <10 HBA and <5 HBD. The ligands-protein binding analyses showed that <B>4l</B> confined in the active binding pocket with three hydrogen bonds observed with His63, Asn66 and Thr197 residues.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hybrid pharmacophore containing sulfonamide, amide and amine designed and synthesized. </LI> <LI> All the derivatives <B>4a-4m</B> showed better inhibition than acetazolamide, with <B>4l</B> exhibiting momentous inhibition. </LI> <LI> The chemo-informatics and ligands-protein binding analyses carried out. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
LSTM based Supply Imbalance Detection and Identification in Loaded Three Phase Induction Motors
Majid, Hussain,Fayaz Ahmed, Memon,Umair, Saeed,Babar, Rustum,Kelash, Kanwar,Abdul Rafay, Khatri International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.1
Mostly in motor fault detection the instantaneous values 3 axis vibration and 3phase current in time domain are acquired and converted to frequency domain. Vibrations are more useful in diagnosing the mechanical faults and motor current has remained more useful in electrical fault diagnosis. With having some experience and knowledge on the behavior of acquired data the electrical and mechanical faults are diagnosed through signal processing techniques or combine machine learning and signal processing techniques. In this paper, a single-layer LSTM based condition monitoring system is proposed in which the instantaneous values of three phased motor current are firstly acquired in simulated motor in in health and supply imbalance conditions in each of three stator currents. The acquired three phase current in time domain is then used to train a LSTM network, which can identify the type of fault in electrical supply of motor and phase in which the fault has occurred. Experimental results shows that the proposed single layer LSTM algorithm can identify the electrical supply faults and phase of fault with an average accuracy of 88% based on the three phase stator current as raw data without any processing or feature extraction.
Radiotherapy in aggressive cutaneous pseudolymphoma:a case report and review of literature
Deepa Joseph,Monica Malik Irukulla,Syed Fayaz Ahmed,Deepthi Valiyaveettil,Syed Akram 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.1
Pseudolymphoma is a nonspecific disease characterized by lesions with lymphomatous-appearing but benign accumulation of inflammatory cells. They generally present as small ulcero-nodular lesions confined to skin which often respond to local therapies. We describe an unusual presentation of an extensive and locally aggressive cutaneous pseudolymphoma in a 21-year-old male patient who presented with extensive cutaneous eruptions gradually progressing over 6 years to involve the entire circumference of his left arm. Magnetic resonance imaging scans of his left arm showed a lesion deeply infiltrating into the soft tissue reaching up to the humerus with intense periosteal reaction. He was successfully treated with radiotherapy after many failed attempts with surgery and chemotherapy.
Radiotherapy in aggressive cutaneous pseudolymphoma: a case report and review of literature
Joseph, Deepa,Irukulla, Monica Malik,Ahmed, Syed Fayaz,Valiyaveettil, Deepthi,Akram, Syed The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.1
Pseudolymphoma is a nonspecific disease characterized by lesions with lymphomatous-appearing but benign accumulation of inflammatory cells. They generally present as small ulcero-nodular lesions confined to skin which often respond to local therapies. We describe an unusual presentation of an extensive and locally aggressive cutaneous pseudolymphoma in a 21-year-old male patient who presented with extensive cutaneous eruptions gradually progressing over 6 years to involve the entire circumference of his left arm. Magnetic resonance imaging scans of his left arm showed a lesion deeply infiltrating into the soft tissue reaching up to the humerus with intense periosteal reaction. He was successfully treated with radiotherapy after many failed attempts with surgery and chemotherapy.
A Review of Structural Testing Methods for ASIC based AI Accelerators
Umair, Saeed,Irfan Ali, Tunio,Majid, Hussain,Fayaz Ahmed, Memon,Ayaz Ahmed, Hoshu,Ghulam, Hussain International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.1
Implementing conventional DFT solution for arrays of DNN accelerators having large number of processing elements (PEs), without considering architectural characteristics of PEs may incur overwhelming test overheads. Recent DFT based techniques have utilized the homogeneity and dataflow of arrays at PE-level and Core-level for obtaining reduction in; test pattern volume, test time, test power and ATPG runtime. This paper reviews these contemporary test solutions for ASIC based DNN accelerators. Mainly, the proposed test architectures, pattern application method with their objectives are reviewed. It is observed that exploitation of architectural characteristic such as homogeneity and dataflow of PEs/ arrays results in reduced test overheads.