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- 검색키워드
- 저자 : Farjadian, Shirin (검색결과 4 건)
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Assessment of pH Responsive Delivery of Methotrexate Based on PHEMA-st-PEG-DA Nanohydrogels
Javad Farzanfar,Fatemeh Farjadian,Amir Roointan,Soliman Mohammadi-Samani,Lobat Tayebi 한국고분자학회 2021 Macromolecular Research Vol.29 No.1
Nanohydrogels (NHs) are novel and attractive carriers for various anticancer factors delivery. The objective of present study is development of a safe NH for pH responsive delivery of methotrexate (MTX). Herein, poly (hydroxyethyl methacrylate) is utilized as the main structure, which is cross-linked with poly(ethyleneglycol) diacrylate (PEG-DA) through reversible addition fragmentation chain transfer polymerization technique. After synthesis, the developed structure is characterized using different methods, including 1H NMR, FT-IR, size exclusion chromatography, transmission electron microscopy and dynamic light scattering. The results confirm successful synthesis of the NH with acceptable yield and nano scale mean size of 194 nm. Methotrexate is conjugated with the aforementioned structure through pH responsive esteric bond. The efficiency of the prepared NH in loading and release of the anticancer drug, methotrexate, is tested. The developed NH shows great potential in methotrexate loading, as well as a faster release rate of methotrexate in acidic pH. The results of in vitro toxicity assessment on MCF-7 as a breast cancer cell line reveal an improved cytotoxicity induction by the methotrexate loaded particles when compared with the free MTX molecules. The suitable size (<200 nm), great potential in loading and release of the methotrexate and cytotoxicity induction in cancer cells are the reliable features of NH as an ideal anti-cancer vehicle.
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Sensitization to common allergens among patients with allergies in major Iranian cities:
Mozhgan Moghtaderi,Saeed Hosseini Teshnizi,Shirin Farjadian 한국역학회 2017 Epidemiology and Health Vol.39 No.-
Various allergens are implicated in the pathogenesis of allergic diseases in different regions. This study attempted to identify the most common allergens among patients with allergies based on the results of skin prick tests in different parts of Iran. Relevant studies conducted from 2000 to 2016 were identified from the MEDLINE database. Six common groups of allergen types, including animal, cockroach, food, fungus, house dust mite, and pollen were considered. Subgroup analysis was performed to determine the prevalence of each type of allergen. The Egger test was used to assess publication bias. We included 44 studies in this meta-analysis. The overall prevalence of positive skin test results for at least one allergen was estimated to be 59% in patients with allergies in various parts of Iran. The number of patients was 11,646 (56% male and 44% female), with a mean age of 17.46±11.12 years. The most common allergen sources were pollen (47.0%), mites (35.2%), and food (15.3%). The prevalence of sensitization to food and cockroach allergens among children was greater than among adults. Pollen is the most common allergen sensitization in cities of Iran with a warm and dry climate; however, sensitization to house dust mites is predominant in northern and southern coastal areas of Iran.
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Soheila Ghasemi,Marzieh Owrang,Farzad Javaheri,Fatemeh Farjadian 한국고분자학회 2022 Macromolecular Research Vol.30 No.5
Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel as a temperatureresponsive polymer was prepared through controlled process using reversible addition fragmentation chain transfer (RAFT) polymerization. The hydrogel was then amino modified using a biocompatible polyamine i.e. spermine and next the antitumor cisplatin drug was conjugated to the modified hydrogel via pH-sensitive spermine linkage. This system had a pH dependency and temperature sensitivity at lower critical solution temperature (LCST). Cisplatin potentially is liberated from the carrier in the acidic environment. However, the release of cisplatin from this polymeric system is increased considerably around the transition temperature of the polymer. The drug release manner of the prepared hydrogel was determined at two pH values (5.5 and 7.4) and three temperatures (37, 40 and 42℃) at different time intervals. The in vitro toxicity assessment was conducted on MCF-7 cell line which showed the system efficiency in killing breast cancer cells.
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Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus
Pourshahidi, Sara,Fakhri, Farnaz,Ebrahimi, Hooman,Fakhraei, Bahareh,Alipour, Abbas,Ghapanchi, Janan,Farjadian, Shirin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.
KCI
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