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        Determining the Optimum Process Parameters of Selective Laser Melting via Particle Swarm Optimization Based on the Response Surface Method

        Fahri Murat,İrfan Kaymaz,Abdullah Tahir Şensoy,İsmail H. Korkmaz 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.1

        Manufacturing high-quality and desired products from additive manufacturing necessitate careful adjustment of the processparameters. Various methods can be utilised to determine optimum process parameters, such as the Taguchi method, Designof Experiments (DoE). Rather than evaluating limited information obtained from statistical analysis of the experiments, optimisationmethods can help find the best possible combination for the process parameters. Therefore, an optimisation approachbased on Particle Swarm Optimization (PSO) was utilised to find the optimum process parameters. The most importantprocess parameters of Selective Laser Melting (SLM) such as laser power, layer thickness, scan speed, and build orientationwere selected as input parameters, and their effects on the tensile properties of the manufactured part were investigated to findout the optimal operating conditions for the SLM process. Since there is not any explicit mathematical expression relatingthese process parameters to the tensile strength, the Response Surface Method (RSM) was used to obtain a meta-model sothat it can be used as an objective function in the optimisation formulation. This approach enabled us to predict the optimumprocess parameters to maximise the tensile strength without conducting an excessive number of experiments. Moreover, themathematical model can also predict tensile strength corresponding to the parameter values that are not tested according tothe DoE chosen for such studies. Furthermore, it was also shown that the PSO outperforms the Genetic Algorithm (GA),which is widely employed to find out the optimum process parameters, in terms of less number of iteration.

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        Effect of IL-18 binding protein on hepatic ischemiareperfusion injury induced by infrarenal aortic occlusion

        Mustafa Ozsoy,Yucel Gonul,Ahmet Bal,Ziya Taner Ozkececi,Ruchan Bahadir Celep,Fahri Adali,Omer Hazman,Ahmet Kocak,Murat Tosun 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.2

        Purpose: Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury. Methods: Wistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 μg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion. Results: Serum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP. Conclusion: This study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.

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