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Tosun, Murat,Soysal, Yasemin,Mas, Nuket Gocmen,Karabekir, Hamit Selim The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.3
Objective : Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line. Methods : In this study, SH-SY5Y cell line was used. After cell culture, the cells were exposed to different doses of MLT and 13-cis-RA. 24 and 48 hours later. While the viabilities was estimated with MTT cell viability assay test, apoptotic indexes were calculated after staining with TUNEL based apoptosis kit. Results : It was observed that MLT has very effective cytotoxic potential than 13-cis-RA on neuroblastoma cell line. At the same time, when MLT and 13-cis-RA were combined, this effect was potentiated. On the other hand, it was found that the effect of 13-cis-RA individually on neuroblastoma cells was very slight. Conclusion : We suggest that in the treatment of patient with neuroblastoma, MLT is very effective and also this effect can be augmented by combination with 13-cis-RA.
On the Trajectory Null Scrolls in 3-Dimensional Minkowski Space-Time E<sub>1</sub><sup>3</sup>
Ersoy, Soley,Tosun, Murat Department of Mathematics 2008 Kyungpook mathematical journal Vol.48 No.1
In this paper, the trajectory scroll in 3-dimensional Minkowski space-time $E_1^3$ is given by a firmly connected oriented line moving with Cartan frame along curve. Some theorems and results between curvatures of base curve and distribution parameter of this surface are obtained. Moreover, some theorems and results related to being developable and minimal of this surface are given. And also, some relationships among geodesic curvature, geodesic torsion and the curvatures of base curve of trajectory scroll are found.
MANNHEIM PARTNER P-TRAJECTORIES IN THE EUCLIDEAN 3-SPACE E3
Zehra Isbilir,Kahraman Esen Ozen,Murat Tosun 호남수학회 2022 호남수학학술지 Vol.44 No.3
Mannheim introduced the concept of a pair of curves, called as Mannheim partner curves, in 1878. Until now, Mannheim partner curves have been studied widely in the literature. In this study, we take into account of this concept according to Positional Adapted Frame (PAF) for the particles moving in the 3-dimensional Euclidean space. We introduce a new type special trajectory pairs which are called Mannheim partner P-trajectories in the Euclidean 3-space. The relationships between the PAF elements of this pair are investigated. Also, the relations between the Serret-Frenet basis vectors of Mannheim partner P-trajectories are given. Afterwards, we obtain the necessary conditions for one of these trajectories to be an osculating curve and for other to be a rectifying curve. Moreover, we provide an example including an illustrative figure.
ON ADJOINT CURVES OF FRAMED CURVES AND SOME RULED SURFACES
( Bahar Doğan Yazıcı ),( Sıddıka Özkaldı Karakuş ),( Murat Tosun ) 호남수학회 2023 호남수학학술지 Vol.45 No.3
In this study, we introduce the adjoint curves of framed curves. We examine some characterizations of adjoint curve of a framed curve. In addition, we give the conditions for framed curves and adjoint curves to be Bertrand and Mannheim curves. Then, we introduce adjoint curves of Frenet-type framed curves and give ruled surfaces related to adjoint curves. Finally, we create normal and binormal surfaces of the framed adjoint curves and obtain some characterizations of these surfaces and we support by the results with figures.
Mustafa Ozsoy,Yucel Gonul,Ahmet Bal,Ziya Taner Ozkececi,Ruchan Bahadir Celep,Fahri Adali,Omer Hazman,Ahmet Kocak,Murat Tosun 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.2
Purpose: Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury. Methods: Wistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 μg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion. Results: Serum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP. Conclusion: This study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.