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Bruno Salomão Hirsch,Igor Braga Ribeiro,Mateus Pereira Funari,Diogo Turiani Hourneaux de Moura,Sergio Eiji Matuguma,Sergio A. Sánchez-Luna,Fabio Catache Mancini,Guilherme Henrique Peixoto de Oliveira 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.5
Background/Aims: Argon plasma coagulation (APC) is the most commonly used endoscopic treatment for gastric antral vascularectasia (GAVE). Endoscopic band ligation (EBL) has emerged as an alternative therapy. Our goal was to evaluate the feasibility,efficacy, and safety of APC and EBL for the treatment of GAVE. This is the first systematic review that included only randomizedcontrolled trials (RCTs) on this topic. Methods: A comprehensive search was performed using electronic databases to identify RCTs comparing APC and EBL for thetreatment of GAVE following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results: Four RCTs were included, with a total of 204 patients. EBL was related to higher endoscopic eradication rates risk difference[RD], 0.29; 95% confidence interval [CI] [0.14, 0.44]; I2=0%) and less bleeding recurrence than APC (RD, 0.29; 95% CI [0.15, 0.44];I2=0%). Patients treated with EBL required fewer blood transfusions (mean difference [MD], 1.49; 95% CI [0.28, 2.71]; I2=96%) andhospitalizations (MD, 0.29; 95% CI [0.19, 0.39]; I2=0%). The number of sessions required for the obliteration of lesions was higherwith APC. There was no difference in the incidence of adverse events. Conclusions: EBL is superior to APC in the treatment of GAVE in terms of endoscopic eradication rates, recurrence of bleeding, andtransfusion requirements.