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Sunflower cake with or without enzymatic complex for broiler chickens feeding
Eveline Berwanger,Ricardo Vianna Nunes,tiago Junior Pasquetti,Alice Eiko Murakami,Taciana Maria Moraes de Oliveira,Douglas Fernando Bayerle,Rafael Frank 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.3
Objective: This study was to evaluate the sunflower cake and enzymatic complex fed to broilers from 22 to 42 d of age. Methods: In a completely randomized design, a total of 850 birds were allotted in a 2×5 factorial scheme (with and without enzymatic complex) and five inclusion levels (0%, 5%, 10%, 15%, 20%) of sunflower cake. There were 5 replications and 17 birds in each experimental unit. Data from performance, carcass yield and intestinal morphology were evaluated. Results: Feed intake, weight gain, final weight and feed:gain ratio linearly worsened as sunflower cake increased. For weight gain, final weight and feed:gain ratio, the birds whose diets contained levels of 15% and 20% of sunflower cake showed worse values (p<0.05) than the birds fed the control diet. When fed the enzymatic complex, birds improved (p<0.05) crypt depth and villus:crypt ratio in the jejunum. As inclusion levels of sunflower cake increased, villus depth and villus:crypt ratio in duodenum, jejunum and ileum linearly reduced and the crypt depth linearly increased. Carcass yield linearly reduced as sunflower cake increased. Conclusion: Based on performance, sunflower cake can be used up to 10% in broilers feeding from 21 to 42 days of age.
Eveline Kelle Ursulino Pontes,Hider Machado Melo,Jose´ Walter Arau´ jo Nogueira,Nairley Cardoso Sa´ Firmino,Ma´rio Geraldo de Carvalho,Francisco Eduardo Araga˜o Catunda Ju´nior,Theodora Thays Arruda C 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.3
Medicinal plants with antimicrobial action havebeen investigated for uses against biofilms, among which,Cymbopogon nardus, citronella, stands out as a promisingspecies. The present study aims to evaluate the antimicrobialand antibiofilm action of the essential oil of C. nardus (EOCN) and geraniol on Gram-negative and positivebacteria from the determination of minimum inhibitoryconcentration (MIC) and minimum bactericidal concentrationand inhibition of biofilms. In the results, the EOCNproduced a 41 mm halo on S. aureus, which was susceptiblewith MIC values of 0.5 and 0.25 mg/mL for theEOCN and geraniol respectively, both with bactericidaleffect. The antibiofilm action was confirmed, the EOCNand geraniol reduced the biofilm biomass of S. aureus up to100% between 0.5 and 4 mg/mL concentrations. Thereduction of cell viability was 0.25 and 1 mg/mL, ofEOCN and geraniol, respectively. EOCN and geraniol wereshown to be promising antibiotic against S. aureus.
Jorijn Neyrinck,Eveline Seghers,Evdokia Tsakiridis 국립민속박물관 2020 International Journal of Intangible Heritage Vol.15 No.1
In the complex web of actors and processes that exists around safeguarding intangible cultural heritage (ICH), museums occupy a special place. The Intangible Cultural Heritage and Museums Project (IMP) has attempted to tackle a range of these issues, and searched for windows of opportunity that emerge where living heritage and museums meet. This paper presents an overview of the themes and issues that informed this networking initiative, and shares key insights that are of wider interest for those engaged in safeguarding ICH and in museums worldwide. IMP aimed to be an incentive to connect the safeguarding of living heritage more closely with museum work, as well as to bring about a better understanding of the questions that arise through dialogue and collaboration between the different stakeholders and perspectives. Throughout the trajectory, a ‘third space’ was uncovered and explored at the intersection between museum and ICH activities. Here, opportunities and risks in the interaction between ICH and museums are negotiated, and moulded into a mutually beneficial platform for all involved. Insights here relate to sustainable development, to ethical questions and concerns, and to the potential of learning networks.
( Carolina C. B. O. Miranda Nantes ),( Eveline A. I. Fonseca ),( Cassia T. B. V. Zaia ),( Robert F. H. Dekker ),( Neelam Khaper ),( Inar A. Castro ),( Aneli M. Barbosa ) 한국균학회 2011 韓國菌學會誌 Vol.39 No.3
Botryosphaeran, a water-soluble exopolysaccharide of the β-(1 → 3;1 → 6)-D-glucan type that has been isolated from the culture medium of Botryosphaeria rhodina MAMB-05 grown in submerged fermentation using glucose as the sole carbon source, was previously demonstrated to be non-genotoxic in peripheral blood and bone marrow, and exhibited strong anticlastogenic activity. In the present study, the effects of botryosphaeran were investigated in streptozotocin-induced diabetic rats as well as in high-fat diet-fed hyperlipidemic Wistar rats. The plasma glucose level was reduced by 52% in the diabetic group of rats after administration of 12 mg botryosphaeran/kg body weight of the rats (b.w.)/day by gavage over 15 days. A reduction in the median ration intake was accompanied by an increase in the median body weight gain, as well as the efficiency of food conversion. These results demonstrate that botryosphaeran has protective effects by reducing the symptoms of cachexia in Diabetes mellitus. Botryosphaeran administered by gavage at a concentration of 12 mg botryosphaeran/kg b.w./ day over 15 days also reduced the plasma levels of total cholesterol and low density lipoprotein-cholesterol by 18% and 27%, respectively, in hyperlipidemic rats. Based on these findings, we conclude that botryosphaeran possesses hypoglycemic and hypocholesterolemic properties in conditions of diabetes mellitus and hyperlipidemia, respectively, and may be used as an oral anti-diabetic agent.
Miranda-Nantes, Carolina C.B.O.,Fonseca, Eveline A.I.,Zaia, Cassia T.B.V.,Dekker, Robert F.H.,Khaper, Neelam,Castro, Inar A.,Barbosa, Aneli M. The Korean Society of Mycology 2011 Mycobiology Vol.39 No.3
Botryosphaeran, a water-soluble exopolysaccharide of the ${\beta}-(1{\rightarrow}3;1{\rightarrow}6)$-D-glucan type that has been isolated from the culture medium of Botryosphaeria rhodina MAMB-05 grown in submerged fermentation using glucose as the sole carbon source, was previously demonstrated to be non-genotoxic in peripheral blood and bone marrow, and exhibited strong anticlastogenic activity. In the present study, the effects of botryosphaeran were investigated in streptozotocin-induced diabetic rats as well as in high-fat diet-fed hyperlipidemic Wistar rats. The plasma glucose level was reduced by 52% in the diabetic group of rats after administration of 12 mg botryosphaeran/kg body weight of the rats (b.w.)/day by gavage over 15 days. A reduction in the median ration intake was accompanied by an increase in the median body weight gain, as well as the efficiency of food conversion. These results demonstrate that botryosphaeran has protective effects by reducing the symptoms of cachexia in Diabetes mellitus. Botryosphaeran administered by gavage at a concentration of 12 mg botryosphaeran/kg b.w./day over 15 days also reduced the plasma levels of total cholesterol and low density lipoprotein-cholesterol by 18% and 27%, respectively, in hyperlipidemic rats. Based on these findings, we conclude that botryosphaeran possesses hypoglycemic and hypocholesterolemic properties in conditions of diabetes mellitus and hyperlipidemia, respectively, and may be used as an oral anti-diabetic agent.
Ribeiro Emanuelle Olympia Silva,Gosselink Rik,Moura Lizandra Eveline da Silva,Correia Raissa Farias,Leite Wagner Souza,Araújo Maria das Graças Rodrigues de,Andrade Armele Dornelas de,Brandão Daniella 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.4
Background: Respiratory muscle strength in patients with an artificial airway is commonly assessed as the maximal inspiratory pressure (MIP) and is measured using analogue or digital manometers. Recently, new electronic loading devices have been proposed to measure respiratory muscle strength. This study evaluates the agreement between the MIPs measured by a digital manometer and those according to an electronic loading device in patients being weaned from mechanical ventilation.Methods: In this prospective study, the standard MIP was obtained using a protocol adapted from Marini, in which repetitive inspiratory efforts were performed against an occluded airway with a one-way valve and were recorded with a digital manometer for 40 seconds (MIPDM). The MIP measured using the electronic loading device (MIPELD) was obtained from repetitively tapered flow resistive inspirations sustained for at least 2 seconds during a 40-second test. The agreement between the results was verified by a Bland-Altman analysis.Results: A total of 39 subjects (17 men, 55.4±17.7 years) was enrolled. Although a strong correlation between MIPDM and MIPELD (R=0.73, P<0.001) was observed, the Bland-Altman analysis showed a high bias of –47.4 (standard deviation, 22.3 cm H2O; 95% confidence interval, –54.7 to –40.2 cm H2O).Conclusions: The protocol of repetitively tapering flow resistive inspirations to measure the MIP with the electronic loading device is not in agreement with the standard protocol using one-way valve inspiratory occlusion when applied in poorly cooperative patients being weaned from mechanical ventilation.
Kim, Jihye,Vasu, Vihas T.,Mishra, Rangnath,Singleton, Katherine R.,Yoo, Minjae,Leach, Sonia M.,Farias-Hesson, Eveline,Mason, Robert J.,Kang, Jaewoo,Ramamoorthy, Preveen,Kern, Jeffrey A.,Heasley, Lynn Oxford University Press 2014 Bioinformatics Vol.30 No.17
<P><B>Motivation:</B> Non–small-cell lung cancer (NSCLC) is the leading cause of cancer death in the United States. Targeted tyrosine kinase inhibitors (TKIs) directed against the epidermal growth factor receptor (EGFR) have been widely and successfully used in treating NSCLC patients with activating EGFR mutations. Unfortunately, the duration of response is short-lived, and all patients eventually relapse by acquiring resistance mechanisms.</P><P><B>Result:</B> We performed an integrative systems biology approach to determine essential kinases that drive EGFR-TKI resistance in cancer cell lines. We used a series of bioinformatics methods to analyze and integrate the functional genetics screen and RNA-seq data to identify a set of kinases that are critical in survival and proliferation in these TKI-resistant lines. By connecting the essential kinases to compounds using a novel kinase connectivity map (K-Map), we identified and validated bosutinib as an effective compound that could inhibit proliferation and induce apoptosis in TKI-resistant lines. A rational combination of bosutinib and gefitinib showed additive and synergistic effects in cancer cell lines resistant to EGFR TKI alone.</P><P><B>Conclusions:</B> We have demonstrated a bioinformatics-driven discovery roadmap for drug repurposing and development in overcoming resistance in EGFR-mutant NSCLC, which could be generalized to other cancer types in the era of personalized medicine.</P><P><B>Availability and implementation:</B> K-Map can be accessible at: http://tanlab.ucdenver.edu/kMap.</P><P><B>Contact:</B> aikchoon.tan@ucdenver.edu or finiganj@njhealth.org</P><P><B>Supplementary information:</B> Supplementary data are available at <I>Bioinformatics</I> online.</P>