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Kwon, Eunji,Cho, Kyung-Bin,Hong, Seungwoo,Nam, Wonwoo The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.42
<P>Hydroxylation of alkanes by a mononuclear nonheme iron(<SMALL>V</SMALL>)–oxo complex, [Fe(<SMALL>V</SMALL>)(O)(TAML)]<SUP>−</SUP>, is initiated by a rate-determining hydrogen atom (H-atom) abstraction, followed by an oxygen non-rebound process. Evidence for the H-atom abstraction–oxygen non-rebound mechanism is obtained experimentally and supported by DFT calculations.</P> <P>Graphic Abstract</P><P>The alkane hydroxylation by a mononuclear nonheme iron(<SMALL>V</SMALL>)–oxo complex occurs <I>via</I> a hydrogen-atom abstraction–oxygen non-rebound mechanism. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc01058b'> </P>
Kwon, Do Young,Kim, Hyun-Mi,Kim, Eunji,Lim, Yeon-Mi,Kim, Pilje,Choi, Kyunghee,Kwon, Jung-Taek JAPANESE SOCIETY OF TOXICOOGICAL SCIENCES 2016 JOURNAL OF TOXICOLOGICAL SCIENCES Vol.41 No.1
<P>Didecyldimethylammonium chloride (DDAC), an antimicrobial agent, has been reported to induce pulmonary toxicity in animal studies. DDAC is frequently used in spray-form household products in combination with ethylene glycol (EG). The purpose of this study was to evaluate the toxic interaction between DDAC and EG in the lung. DDAC at a sub-toxic dose (100 mu g/kg body weight) was mixed with a non-toxic dose of EG (100 or 200 mu g/kg body weight), and was administrated to rats via intratracheal instillation. Lactate dehydrogenase activity and total protein content in the bronchoalveolar lavage fluid (BALF) were not changed by singly treated DDAC or EG, but significantly enhanced at 1 d after treatment with the mixture, with the effect dependent on the dose of EG. Total cell count in BALF was largely increased and polymorphonuclear leukocytes were predominantly recruited to the lung in rats administrated with the mixture. Inflammatory cytokines, tumor necrosis factor-alpha and interleukin-6 also appeared to be increased by the mixture of DDAC and EG (200 mu g/kg body weight) at 1 d post-exposure, which might be associated with the increase in inflammatory cells in lung. BALF protein content and inflammatory cell recruitment in the lung still remained elevated at 7 d after the administration of DDAC with the higher dose of EG. These results suggest that the combination of DDAC and EG can synergistically induce pulmonary cytotoxicity and inflammation, and EG appears to amplify the harmful effects of DDAC on the lung. Therefore pulmonary exposure to these two chemicals commonly found in commercial products can be a potential hazard to human health.</P>
Eunji Lee,Soon Hyung Kwon,Poo Reum Choi,Ji Chul Jung,Myung-Soo Kim 한국탄소학회 2015 Carbon Letters Vol.16 No.2
Activated carbons (ACs) were prepared by activation of coal tar pitch (CTP) in the range of 700°C-1000°C for 1-4 h using potassium hydroxide (KOH) powder as the activation agent. The optimal activation conditions were determined to be a CTP/KOH ratio of 1:4, activation temperature of 900°C, and activation time of 3 h. The obtained ACs showed increased pore size distribution in the range of 1 to 2 nm and the highest specific capacitance of 122 F/g in a two-electrode system with an organic electrolyte, as measured by a charge-discharge method in the voltage range of 0-2.7 V. In order to improve the performance of the electric double-layer capacitor electrode, various mixtures of CTP and petroleum pitch (PP) were activated at the optimal activation conditions previously determined for CTP. Although the specific capacitance of AC electrodes prepared from CTP only and the mixtures of CTP and PP was not significantly different at a current density of 1 A/g, the AC electrodes from CTP and PP mixtures showed outstanding specific capacitance at higher current rates. In particular, CTP-PP61 (6:1 mixture) had the highest specific capacitance of 132 F/g, and the specific capacitance remained above 90% at a high current density of 3 A/g. It was found that the high specific capacitance could be attributed to the increased micro-pore volume of ACs with pore sizes from 1 to 2 nm, and the high power density could be attributed to the increased meso-pore volume.
Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents
Kwon, Byeongsu,Han, Eunji,Yang, Wonseok,Cho, Wooram,Yoo, Wooyoung,Hwang, Junyeon,Kwon, Byoung-Mog,Lee, Dongwon American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.9
<P>Cancer cells, compared to normal cells, are under oxidative stress associated with an elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress induced by ROS generating agents. Thus, manipulation of the ROS level provides a logical approach to kill cancer cells preferentially, without significant toxicity to normal cells, and great efforts have been dedicated to the development of strategies to induce cytotoxic oxidative stress for cancer treatment. Fenton reaction is an important biological reaction in which irons convert hydrogen peroxide (H2O2) to highly toxic hydroxyl radicals that escalate ROS stress. Here, we report Fenton reaction-performing polymer (PolyCAFe) micelles as a new class of ROS-manipulating anticancer therapeutic agents. Amphiphilic PolyCAFe incorporates H2O2-generating benzoyloxycinnamaldehyde and iron-containing compounds in its backbone and self-assembles to form micelles that serve as Nano-Fenton reactors to generate cytotoxic hydroxyl radicals, killing cancer cells preferentially. When intravenously injected, PolyCAFe micelles could accumulate in tumors preferentially to remarkably suppress tumor growth, without toxicity to normal tissues. This study demonstrates the tremendous translatable potential of Nano-Fenton reactors as a new class of anticancer drugs.</P>
20-40대 한국 남녀 성인의 밀키트 이용실태와 영양지수
권은지(Eunji Kwon),강현주(Hyunjoo Kang),이홍미(Hongmie Lee) 충북대학교 생활과학연구소 2023 생활과학연구논총 Vol.27 No.1
Background/Objects: This study was conducted in order to investigate the relationship between the frequency of using meal kits and the Nutrition Quotient (NQ) of adult men and women by age group. Methods: An online survey was conducted on 301 people (170 females/131 males; age group 138/20s, 82/30s, 81/40s; using frequency, 70 in high-frequency/166 in low-frequency) nationwide. Results: The usage status was compared by gender More of high-frequency group (57.1%) and in the high-age group (57.8%) purchased meal kits online market, regardless of gender. The rate of spending ‘more than 13,000 won' on purchases was high among men (52.1%), 40s (59.4%), and high-frequency group (65.7%). When purchasing meal kits, the first priority was ‘taste' in both gender, but the second priority was ‘convenience' in men and ‘contents' for women. The purpose of purchasing meal kits ‘family meal’ was ranked first for both gender, but ‘meals while traveling' (9.2%) and ‘snacks' (11.7%) ranked second for women and men, respectively. Without difference by gender, age group, or frequency of use, the most answered reasons for using meal kits were ‘simple cooking', followed by ‘short cooking time' > cheaper than eating-out > various menu > shorter shopping time > sense of accomplishment of cooking by myself > convenient storage and the most frequently using menu was soup/tang/stew, followed by noodles > rice > snacks > side dishes > salads. The frequency of using meal kits was positively associated with NQ in balance section for men in their 30s and women in their 40s and negatively with that in moderation section, especially for men in their 30s and 40s and women in their 40s. Conclusion: The results suggested that frequent meal kit eaters need to be educated on the quality of meals and eating behaviors to keep in mind.