New Records of Two Genera Leptoseris and Phyllangia (Anthozoa: Hexacorallia: Scleractinia) from Korea

Choi, Eunae,Song, Jun-Im The Korean Society of Systematic Zoology 2015 Animal Systematics, Evolution and Diversity Vol.31 No.3

Two scleractinian species are newly recorded in Korea: Leptoseris mycetoseroides Wells, 1954 and Phyllangia hayamaensis (Eguchi, 1968). The two genera Leptoseris Milne Edwards and Haime, 1849 and Phyllangia Milne Edwards and Haime, 1848 are also newly recorded in Korea. The specimens were collected from the subtidal zones of Jeju-do Island, Korea by SCUBA diving from 1991 to 2007. Leptoseris mycetoseroides is characterized by its platelike growth form, intratentacular budding, irregularly developed collines, single styliform columella, and even septa and septocostae. Phyllangia hayamaensis is distinguished by its encrusting and plocoid growth form of corallites basally united with common coenosteum, trabecular columella, and irregular septal arrangements and paliform lobes.

A New Record of Dendrophyllia compressa (Anthozoa: Hexacorallia: Scleractinia: Dendrophylliidae) from Korea

Choi, Eunae,Song, Jun-Im The Korean Society of Systematic Zoology 2016 Animal Systematics, Evolution and Diversity Vol.32 No.1

Dendrophyllia compressa Ogawa and Takahashi, 1995 is newly reported from Korea. The specimen was collected off Seogwipo, Jeju-do, Korea in 1969. It is described herein based on the morphological characters of the skeletal structures. Dendrophyllia compressa is characterized by its small and bushy growth form with branches, vertical growth direction, small calicular diameter, compressed calice, Pourtalès Plan with vertical septal inner edges, flat and spongy columella, exserted septal upper margins, and epitheca. Dendrophyllia compressa has been synonymized with Cladopsammia eguchii . However, the former species differs from the latter species in its growth form, growth direction, colony size, corallite size, and corallite shape.

Change of Surviving Fractions based on the Recovery of Potentially Lethal Damage in HFL-I Cell Line

Eunae Choi 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.3

Potentially lethal damage repair (PLDR) in HFL-I was investigated by delayed plating experiments. The surviving fraction data were fitted to the linear Quadratic equation (LogSn=-nγ(αd+βd2) where γ=1 for immediate plating). And a repair factor γ was developed to compare survival for immediate and delayed plating . When we only took into account the repair factor of PLDR γ which was derived from the delay assay, the cell survival response th fractionated carbon ion irradiation was not fully matched. This gap suggested that consideration of another repair process is necessary. So this suggests that the various repair process plays an important role in the fractionated irradiations.

Four New Records of Two Genera Balanophyllia and Cladopsammia (Anthozoa: Hexacorallia: Scleractinia: Dendrophylliidae) from Korea

Eunae Choi,Jun-Im Song 한국동물분류학회 2014 Animal Systematics, Evolution and Diversity Vol.30 No.3

The four species of the family Dendrophylliidae are newly recorded in Korea: Balanophyllia (Balanophyllia) cumingii Milne Edwards and Haime, 1848, Balanophyllia (Balanophyllia) vanderhorsti Cairns, 2001, Cladopsammia eguchii (Wells, 1982), and Cladopsammia gracilis (Milne Edwards and Haime, 1848). The two genera of Balanophyllia and Cladopsammia, to which the four species belong, are newly recorded in Korea. They were collected from the subtidal zones in Jeju-do Island, Korea by SCUBA diving from 1987 to 2012. This study aims to identify the four dendrophyllid species based on external and internal morphological characters including growth form, size, budding, and color of colonies, shape and size of corallites, columella, theca, and septa. Balanophyllia (Balanophyllia) cumingii is distinguished by its solitary growth form, small and low subturbinate corallite with enlarged calice, and expanded basal part, exsert first and second septa, and Pourtales plan. Balanophyllia (Balanophyllia) vanderhorsti is characterized by its quasi-colonial growth form, subturbinate corallites with compressed calice, thick theca, and Pourtales plan. Cladopsammia eguchii is characterized by its phaceloid growth form of compressed corallites basally united with common coenosteum, flat spongy columella, thick theca, and Pourtales plan. Cladopsammia gracilis is distinguished by its phaceloid growth form of corallites basally united with common coenosteum, and pronounced Pourtales plan forming flower patterns.

Enhancing bio-availability of β-naphthoflavone by supramolecular complexation with 6,6′-thiobis(methylene)-β-cyclodextrin dimer

Choi, Jae Min,Cho, Eunae,Lee, Benel,Jeong, Daham,Choi, Youngjin,Yu, Jae-Hyuk,Jung, Seunho Elsevier 2016 Carbohydrate polymers Vol.151 No.-

<P><B>Abstract</B></P> <P>The aryl hydrocarbon receptor (AhR) is a ligand activated transcriptional regulator, which governs key biological processes including detoxification of carcinogens. β-Naphthoflavone (β-NF) is a non-toxic flavonoid, and a potent AhR agonist. Thus, β-NF can induce the representative detoxifying enzyme cytochrome P4501A1, thereby enhancing the detoxification potential. However, its low water solubility hampers the use. We found that supramolecular complexation of β-NF with the synthetic 6,6′-thiobis(methylene)-β-cyclodextrin (β-CD-S) dimer significantly enhanced β-NF’s role as an AhR agonist. The water solubility of β-NF was increased to 469 fold by effective supramolecular complexation with the β-CD-S dimer, and caused significant induction of cytochrome P4501A1. Stable formation of the supramolecular complex of β-NF with β-CD-S-dimer was verified by various analyses. In summary, supramolecular complexation of β-NF with β-CD-S dimer greatly enhanced bio-availability of β-NF as an AhR agonist. Our findings provide an easy, non-destructive, and alternative approach to enhance the bio-availability of therapeutics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 6, 6′-Thiobis(methylene)-β-cyclodextrin dimer (β-CD-S-dimer) was synthesized. </LI> <LI> The β-CD-S-dimer was used to enhance β-naphthoflavone’s water solubility. </LI> <LI> The solubilized β-NF by complexation significantly induced the cytochrome P4501A1 activity. </LI> <LI> β-NF supramolecular complex with β-CD-S-dimer enhanced the bio-functionality of β-NF. </LI> <LI> Various instrumental analyses were performed to verify the formation of a supramolecular complex. </LI> </UL> </P>

Solubility and bioavailability enhancement of ciprofloxacin by induced oval-shaped mono-6-deoxy-6-aminoethylamino-β-cyclodextrin

Choi, Jae Min,Park, Kyeonghui,Lee, Benel,Jeong, Daham,Dindulkar, Someshwar D,Choi, Youngjin,Cho, Eunae,Park, Seyeon,Yu, Jae-hyuk,Jung, Seunho Elsevier 2017 Carbohydrate polymers Vol.163 No.-

<P><B>Abstract</B></P> <P>Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections; however, its limited aqueous solubility inhibits its broader clinical uses. This study investigated the complexation effect of mono-6-deoxy-6-aminoethylamino-β-cyclodextrin on the aqueous solubility and bioavailability of ciprofloxacin. During complexation, the oval-shaped cavity induced by mono-aminoethylamine substitution on the primary rim of β-cyclodextrin, was considered to be a key factor according to NMR spectroscopy and molecular modeling studies. The ciprofloxacin with mono-6-deoxy-6-aminoethylamino-β-cyclodextrin complex was characterized using FE-SEM, DSC, FT-IR, T1 relaxation, 2D NOESY, and DOSY NMR spectroscopy and molecular modeling studies. The solubility property of ciprofloxacin complexed with mono-6-deoxy-6-aminoethylamino-β-cyclodextrin was enhanced by seven-fold compared to that of pure ciprofloxacin. Furthermore antibacterial activity of that complex against methicillin-resistant <I>Staphylococcus aureus</I> was enhanced and it clearly showed the growth inhibition. The mono-6-deoxy-6-aminoethylamino-β-cyclodextrin has the potential to be utilized for other oblong guest molecules besides ciprofloxacin based on the novel induced elliptical cavity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mono-6-deoxy-6-aminoethylamino-β-cyclodextrin (Et-β-CD) was synthesized. </LI> <LI> Oval-shaped cavity within Et-β-CD was induced by mono aminoethylamine substitution. </LI> <LI> Ciprofloxacin (CIP)/Et-β-CD complex was thoroughly characterized. </LI> <LI> CIP/Et-β-CD complex effectively enhanced the bioavailability and solubility of CIP. </LI> </UL> </P>

New Records of Two Zooxanthellate Scleractinian Corals (Anthozoa: Hexacorallia: Scleractinia) from Korea

Eunae Choi,Jun-Im Song 한국동물분류학회 2015 Animal Systematics, Evolution and Diversity Vol.31 No.2

The two zooxanthellate scleractinian corals are newly recorded in Korea: Psammocora albopicta Benzoni, 2006 of the family Psammocoridae and Oulastrea crispata (Lamarck, 1816) of the family Faviidae. These families are also newly recorded in Korea. Specimens were collected from the subtidal zones of Jeju-do Island, Korea by SCUBA diving from 1999 to 2014. Two scleractinians are described based on the morphological characters of skeletal structures. Psammocora albopicta is distinguished by its encrusting cerioid growth form, high density of corallites, small calicular diameter, single styliform columella, and fewer rows of enclosed septa. Oulastrea crispata is characterized by its encrusting plocoid growth form, polygonal calicular shape, irregular paliform lobes, and papillose columella.

A New Record of Deep-Sea Scleractinian Coral of the Family Flabellidae (Anthozoa: Hexacorallia) from Korea

Choi, Eunae,Moon, Hye-Won The Korean Society of Systematic Zoology 2022 Animal Systematics, Evolution and Diversity Vol.38 No.1

This study newly records a deep-sea coral, Flabellum (Ulocyathus) deludens from Korea. The specimens were collected by trawling at a depth of 100 m off Jejudo Island in 2019. The newly recorded species is described and compared with the other similar consubgeneric species in detail based on morphological characteristics, including corallum size, calicular diameter, calicular edge, face angle, edge angle, and septal arrangement. Flabellum(Ulocyathus) deludens is characterized by its solitary, highly compressed, wedge-shaped corallite with a small cylindrical pedicel, radiating inverse chevron-patterned lateral stripes on thecal faces, highly jagged calicular edges, and hexameral septal arrangement in five cycles. As a result of this study, five species in the family Flabellidae have been recorded from Korea.

Biophysical Model Including a Potentially Lethal Damage Repair Parameter in Fractionated Carbon Beam

Choi Eunae,Yoon Myonggeun,Suzuki Masao,Matsufuji Naruhiro,Jung Wonguyn 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.2

The amount of potentially lethal damage repair (PLDR) is a significant factor in the process of modeling the survival curves of cells irradiated with fractionated carbon beams. Because the amount of PLDR generally depends on the features of the cells and the linear energy transfer (LET), the amount of PLDR of cells irradiated with fractionated carbon beams shows distinct differences from that of cells irradiated with X-rays. This study considered a new parameter dependent on the correlation between the PLDR trait (T) of the cells over a time interval (Δ) at the fractionated carbon beam irradiation. The survival curves of the cells irradiated with fractionated carbon beams n times were predicted using the ζ and the Ψ values from the delay assay. This study aims to overcome the barriers of traditional methods by developing a new survival curve model with new parameters based on an analysis of the PLDR traits of cells over time interval in fractionated carbon beam irradiation and to suggest a model that produces results significantly closer to the experimental data.

Monte Carlo simulation of base damage as a function of linear energy transfer for applications in radiation biophysics

Choi Eunae,Kim Youme,천권수 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.10

This work presents simulations of the concentration of clustered DNA damage of various complexities induced by monoenergetic electrons, protons, and alpha particles within the range of linear energy transfer (LET). Using Geant4-DNA tool, we measured the LET in liquid water and calculated the frequency of base damage around single strand breaks, double strand breaks, and complex strand breaks. The protons and the alpha particles depended greatly on LET, which affected the concentration of base damage. For alpha particles, at 206.40 keV/μm, a high LET region was irradiated, the number of cases with more than 6 base damages was increased by about 70 times compared to the low LET region. The data indicate that high-LET radiation is likely to be much more effective in producing concentrated clusters of damage, and that having a quantitative estimate of the extent of this type of damage is important. These lesions are responsible for most of the significant cellular effects associated with ionizing radiation.