P181 : The expression of c-Jun in various skin tumors

( Bum Joon Ko ),( Hong Ki Cho ),( Kyung O Kim ),( Han Eul Lee ),( Young Lip Park ),( Jong Suk Lee ),( Kyu Uang Whang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: c-Jun, along with JunB, JunD and Fos group proteins, comprises the core members of the activator protein 1(AP1) family of transcription factors. Recent many studies have demonstrated that AP1 has key roles in regulating a wide spectrum of biological processes, including tumorigenesis. So We hypothesized that c-Jun has influence on differentiation and malignant change of various skin tumors. Objectives: This study was investigate to measure the expression of c-Jun in different skin tumors. Methods: The expression of c-Jun was examined by immunohistochemical staining of 46 specimens of skin tumors including 2 cases of pigmented nevus, 2 cases of dysplastic nevus, 4 case of seborrheic keratosis, 4 case of keratoacanthoma, 4 cases of actinic keratosis, 4 cases of bowen disease, 16 cases of squamous cell carcinoma, 4 case of basal cell carcinoma and 6 cases of malignant melanoma. Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expression of c-Jun in malignant melanoma than other skin tumors. Conclusion: These findings showed that c-Jun have a positive association with the malignancies of the skin tumors and suggested the role of c-Jun in the protection of malignant changes including loss of differentiation and dysplasia in skin tumors.

재무제표 구조 개선에 관한 연구 : 국제비교 중심으로

이대선,고완석,유청을,송기신,박성환 서강대학교 경영학연구원 2002 서강경영논총 Vol.13 No.1

A STUDY OF HYDRODENITROGENATION OF PYRIDINE VOER MOLYBDENUM NITRIDE CATALYSTS AND THEIR CHARACTERIZATION

Chang, Jae Hoon,Ko, Eul Suk,Park, Sung Ha,Kim, Kyung Lim 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.2

A series of molybdenum nitride (Mo₂N) catalysts were prepared by a topotactic synthesis method using a TPR (Temperature Programmed Reaction) at various conditions (temperature ramping rate, NH₃ gas flow rate, final preparation temperature). The surface property and acidity of Mo₂N catalysts prepared at various prepared conditions were studied by SEM, XRD, BET, FT-IR and TGA. The hydrodenitrogenation (HDN) of pyridine in n-heptane over Mo₂N catalyst (A1) was studied in a fixed bed continuous flow reactor (CATATEST) at the temperatures between 250-450℃, the pressure at 20-40×10^5 Pa and the contact time between 0.01-0.05 g cat.hr./㎖ feed. The microstructure of Mo₂N catalyst was not changed at various preparatioin conditions by topotactic reaction. The XRD and BET studies showed that the extent of the crystallinity and the surface area of the prepared Mo₂N catalysts increased when the final preparation temperature increased and the temperature ramping rate was lowered. In addition, from the TGA curve, the acid strength increased with the increase of the NH₃ gas flow rate. The results of pyridine hydrodenitrogenation (HDN) over Mo₂N catalyst showed that the catalytic activity (conversion %) increased as reaction temperature, reaction pressure, and contact time increases. The selectivity for piperidine possessed a maximum at 350℃ regardless of the reaction pressure. Also, the selectivity for cracked products increased as reaction temperature and pressure increased. The activation energy was determined 7.16 ㎉/㏖ by Arrehenius plot.

A Study of Hydrodenitrogenation of Pyridine over Molybdenum Nitride Catalysts and Their Characterization

Kim, Kyung Lim,Chang, Jae Hoon,Ko, Eul Suk,Park, Sung Ha 한국화학공학회 1995 NICE Vol.13 No.3

A series of molybdenum nitride(Mo₂N) catalysts were prepared by a topotactic synthesis method using a TPR(Temperature Programmed Reaction) at various conditions(temperature ramping rate, NH₃ gas flow rate, final preparation temperature). The surface property and acidity of Mo₂N catalysts prepared at various prepared conditions were studied by SEM, XRD, BET, FT-IR and TGA. The hydrodenitrogenation(HDN) of pyridine in n-heptane over Mo2N catalyst (A1) was studied in a fixed bed continuous flow reactor (CATATEST) at the temperatures between 250-4500, the pressure at 20-40 X 10^5 Pa and the contact time between 0.01-0.05 g cat.hr./ml feed. The microstructure of Mo₂N catalyst was not changed at various preparation conditions by topotactic reaction. The XRD and BET studies showed that the extent of the crystallinity and the surface area of the prepared Mo₂N catalysts increased when the final preparation temperature increased and the temperature camping rate was lowered. In addition, from the TGA curve, the acid strength increased with the increase of the NH₃ gas flow rate. The results of pyridine hydrodenitrogenation(HDN) over Mo₂N catalyst showed that the catalytic activity (conversion %) increased as reaction temperature, reaction pressure, and contact time increases. The selectivity for piperidine possessed a maximum at 3500 regardless of the reaction pressure. Also, the selectivity for cracked products increased as reaction temperature and pressure increased. The activation energy was determined 7.16 kcal/mol by Arrehenius plot.

CoMo/γ-Al₂O₃촉매상에서 VO-TPP의 수소 첨가 탈금속반응에 관한 연구

심현섭,박해경,고을석,김경림,Shim, Hyeon-Seop,Park, Hea-Kyung,Ko, Eul-Suk,Kim, Kyung-Lim 한국공업화학회 1993 공업화학 Vol.4 No.4

$CoMo/{\gamma}-Al_2O_3$ 촉매상에서 $300{\sim}400^{\circ}C$의 온도와 $15-30{\times}10^5$ Pa의 압력 그리고 접촉시간 0.008-0.020 gcat. hr. /ml feed 범위에서 VO-TPP(VO-tetraphenylporphyrin)의 수소 첨가 탈금속반응에 관하여 연구하였다. VO-TPP의 수소 첨가 탈금속반응에서 pyridine 농도 4mole%까지는 농도가 증가함에 따라 전화율의 감소가 나타났으므로 pyridine은 수소 첨가 탈금속반응을 억제한다. $350^{\circ}C$ 이상의 온도에서는 VO-TPP의 외관상 반응차수가 1차였으며, Arrhenius plot에서 얻은 활성화 에너지는 약 23kcal/mole이었다. Fresh 촉매와 aged 촉매의 pore size distribution과 흡착, 탈착 isotherm으로부터 pore mouth-plugging 현상을 확인할 수 있었다. Hydrodemetallation(HDM) of VO-tetraphenylporphyrin(VO-TPP) was studied over $CoMo/{\gamma}-Al_2O_3$ catalyst at emperatures between $300^{\circ}C$ and $400^{\circ}C$, the total pressure between $15{\times}10^5$ and $30{\times}10^5$ Pa and the contact times between 0.008 and 0.020gcat. hr./ml teed. HDM of VO-TPP was inhibited by pyridine because the increase of pyridine concentration(up to 4mole%) caused the decrease of HDM conversion. The reaction rate of VO-TPP was found to be apparently 1st order over $350^{\circ}C$ and its activation energy was determined to be about 23kca1/mo1e by Arrhenius plot. Pore mouth-plugging phenomena were shown by ad/desorption isotherm and pore size distribution of fresh and aged catalysts.

CoMo / γ- Al2O3 촉매상에서 VO - TPP 의 수소 첨가 탈금속반응에 관한 연구

심현섭,박해경,고을석,김경림 ( Hyeon Seop Shim,Hea Kyung Park,Eul Suk Ko,Kyung Lim Kim ) 한국공업화학회 1993 공업화학 Vol.4 No.4

CoMo/γ-A1_2O_3 촉매상에서 300∼400℃의 온도와 15-30×10^5 Pa의 압력 그리고 접촉시간 0.008-0.020gcat. hr. /ml feel 범위에서 VO-TPP(VO-tetraphenylporphyrin)의 수소 첨가 탈금속반응에 관하여 연구하였다. VO-TPP의 수소 첨가 탈금속반응에서 pyridine 농도 4mole%까지는 농도가 증가함에 따라 전화율의 감소가 나타났으므로 pyridine은 수소 첨가 탈금속반응을 억제한다. 350℃ 이상의 온도에서는 VO-TPP의 외관상 반응차수가 1차였으며, Arrhenius plot에서 얻은 활성화 에너지는 약 23㎉/mole이었다. Fresh 촉매와 aged 촉매의 pore size distribution과 흡착, 탈착 isotherm으로부터 pore mouth-plugging 현상을 확인할 수 있었다. Hydrodemetallation (HDM) of VO-tetraphenylporphyrin (VO-TPP) was studied over CoMo/γ-Al_2O_3 catalyst at emperatures between 300℃ and 400℃, the total pressure between 15×10^5 and 30×10^5 Pa and the contact times between 0.008 and 0.020gcat. hr./ml feed. HDM of VO-TPP was inhibited by pyridine because the increase of pyridine concentration(up to 4mole%) caused the decrease of HDM conversion. The reaction rate of VO-TPP was found to be apparently 1st order over 350℃ and its activation energy was determined to be about 23㎉/mole by Arrhenius plot. Pore mouth-plugging phenomena were shown by ad/desorption isotherm and pore size distribution of fresh and aged catalysts.

학술발표회 초록 ( 촉매 및 반응공학 (4) ) : 질화 Mo , CoMo NiMo /γ - Al2O3 , 비담지 Mo2N 및 상업용 HR - 306 촉매상에서 DBT 의 수소첨가 탈황반응과 그 속도론에 관한 연구

박해경(Hea Kyung Park),이진구(Jihn Koo Lee),김두성(Du Soung Kim),고을석(Eul Suk Ko),김경림(Kyung Lim Kim) 한국화학공학회 1994 추계학술발표회 Vol.- No.-