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Andri Maruli Tua Lubis,Erick Wonggokusuma,Aldo Fransiskus Marsetio 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.1
Purpose: Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intraarticular injection of growth hormone (GH) in OAinduced rabbit knees compared to hyaluronic acid (HA) and placebo.Materials and Methods: A total of 21 male, skeletally mature, New Zealand rabbits received an intraarticular type II collagenase injection for OA induction. Two weeks later, the rabbits were randomized into three groups based on the weekly intraarticular injection to be received: GH, HA, and saline. Injections were done for three consecutive weeks. Evaluation was done at 8 weeks after treatment, clinically using the lameness period, macroscopically using the Yoshimi score and microscopically using the Mankin score. Results: The shortest period of lameness was found in the GH group (15.9±2.12 days), compared to the HA group (19.4±1.72 days) and placebo group (25.0±2.94 days). There was a statistically significant difference in macroscopic scoring between groups (p=0.001) in favor of the GH group. There was also significant difference in the microscopic score between groups (p=0.001) also in favor of the GH group.Conclusions: Intraarticular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo.