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Eojin Jeon,Wooseub Kim,Hyeseung Kim,Sundo Choi 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
Nuclear power plants, which are important national facilities, require special attention against the threat of terrorism using various methods. Among the terrorist threats, as structural damage and human casualties due to explosions continue to occur, interest in the blast load is increasing. However, domestic nuclear power plants do not have sufficient design requirements for protection against the threat of explosives. To prepare for the threat of terrorism using explosives, it is necessary to evaluate the physical protection performance of nuclear power plants against blast load, and to use this to improve protection performance and establish regulatory standards. Most of the explosion-proof designs used abroad use the empirical chart presented by UFC 3-340- 02 (DoD 2008), which does not take into account the effect of near-field explosions. When explosions occur inside nuclear power plants, near-field explosions occur in most cases. In this study, it was assumed that explosives were installed in the corridor inside nuclear power plants. A spherical TNT was placed in the middle of the corridor floor to simulate near-field explosions, and the structure response according to the weight of the TNT was evaluated. The corridor was modeled with a reinforced concrete material and the LS-DYNA program was used for analysis. For the explosion model, the Arbitrary-Lagrangian-Eulerian (ALE) analysis technique applying the advantages of the Lagrangian and Eulerian methods were used. By analyzing the pressure history and the degree of deformation of the structure according to the explosion, the degree of threat caused by the explosion was analyzed. Based on the analysis of this study, physical barriers performance database (DB) using Modeling & Simulation (M&S) will be constructed by performing sensitive analysis such as representative structure shape setting, boundary conditions, material of structures, etc. The constructed DB is expected to be used to establish regulatory standards for the physical barriers of nuclear power plants related to explosives.
Lee, Seung Hee,Jeong, Eojin,Paik, Sun-Sook,Jeon, Ji Hyun,Jung, Sung Won,Kim, Hyun-Bok,Kim, Muyan,Chun, Myung-Hoon,Kim, In-Beom Informa Healthcare USA, Inc. 2014 Current eye research Vol.39 No.1
<P><I>Purpose</I>: To investigate the effect of cyanidin-3-<I>O</I>-glucoside (C3G) on a rat retinal degeneration (RD) model.</P><P><I>Materials and methods</I>: Experimental RD was induced in rats by the intraperitoneal injection of <I>N</I>-methyl-<I>N</I>-nitrosourea (MNU) at 50 mg/kg. C3G extracted from mulberry (<I>Morus alba </I>L.) fruit (50 mg/kg) was orally administered, daily for 1, 2 and 4 weeks after MNU injection. The effects of C3G administration on MNU-induced RD retinas were histologically and functionally assessed by hematoxylin and eosin staining and electroretinography (ERG), respectively. The degree of retinal injury in C3G-administered RD rats was evaluated by immunohistochemistry with an antibody against glial fibrillary acidic protein (GFAP). The preferential protective effect of C3G on scotopic vision was examined by western blot analysis.</P><P><I>Result</I>s: Marked loss of photoreceptors in the outer nuclear layer (ONL) was observed in RD rats at 2 and 4 weeks after MNU injection, while the ONL in the MNU-induced RD rats given C3G was relatively well preserved. Immunohistochemistry with anti-GFAP showed that retinal injury was also reduced in the retinas of the rats given C3G. Functional assessment by using ERG recordings showed that scotopic ERG responses were significantly increased in RD rats given C3G for 4 weeks (<I>p</I> < 0.01) compared with that of untreated RD rats. In the RD rats given short-term C3G (for 1 and 2 weeks), the increase in ERG responses was not significant. In addition, western blot analysis showed that rhodopsin level in the C3G-administered RD retinas significantly increased compared to that in the non-administered RD retinas (<I>p</I> < 0.05), whereas red/green opsin level did not show any significant difference.</P><P><I>Conclusions</I>: Long-term administration of C3G extracted from mulberry fruit could structurally reduce photoreceptor damage and functionally improve scotopic visual functions in the RD rat model induced by MNU.</P>