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RISS 인기검색어
- 검색키워드
- 저자 : Enyue Ji (검색결과 5 건)
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Analytical solution and experimental study of membrane penetration in triaxial test
Ji, Enyue,Zhu, Jungao,Chen, Shengshui,Jin, Wei Techno-Press 2017 Geomechanics & engineering Vol.13 No.6
Membrane penetration is the most important factor influencing the measurement of volume change for triaxial consolidated-drained shear test for coarse-grained soil. The effective pressure p, average particle size $d_{50}$, thickness $t_m$ and elastic modulus $E_m$ of membrane, contact area between membrane and soil $A_m$ as well as the initial void ratio e are the major factors influencing membrane penetration. According to the membrane deformation model given by Kramer and Sivaneswaran, an analytical solution of the membrane penetration considering the initial void ratio is deduced using the energy conservation law. The basic equations from theory of plates and shells and the elastic mechanics are employed during the derivation. To verify the presented solution, isotropic consolidation tests of a coarse-grained soil are performed by using the method of embedding different diameter of iron rods in the triaxial samples, and volume changes due to membrane penetration are obtained. The predictions from presented solution and previous analytical solutions are compared with the test results. It is found that the prediction from presented analytical solution agrees well with the test results.
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Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
Baek, In-Ji,Jeon, Su-Bun,Song, Min-Ji,Yang, Enyue,Sohn, Uy-Dong,Kim, In-Kyeom The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300 $({\mu}M$) or vehicle. We determined the phosphorylation level of the myosin light chain ($MLC_{20}$), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of $MLC_{20}$ phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619 or NaF-induced phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, the downstream effectors of Rho-kinase. In regards to the $Ca^{2+}$-free solution, flavone inhibited the phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, as well as vascular contractions induced by U 46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.
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Study on the Tensile Properties and Application of Gravelly Soil Reinforced by Polypropylene Fiber
Zhitao Zhang,Enyue Ji,Zhongzhi Fu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8
Incorporating fibers into gravelly soil is an effective method to prevent the core wall of high earth core rockfill dams (ECRDS) from cracking. In this study, a new type of soil tensile device was used to carry out tensile tests on gravelly soil with different gravel contents and fiber contents. The test results show that as the gravel content increases from 0% to 50%, the improvement in tensile strength decreases from 48.9% to 6.4%, which means the increase in gravel content reduces the improvement in tensile strength significantly. The ultimate tensile strain, tensile strength, and post-peak tensile strength of fiber-reinforced gravelly soil are positively correlated with the fiber content. Combined with the Scanning electron microscopy (SEM) results, the reinforcement effect of the three types of fiber interfaces on the gravel soil is qualitatively analyzed, and the microscopic mechanism of the improvement of the tensile strength of fiber-reinforced gravelly soil is revealed. The energy absorption capacity (EAC) results showed that the lower the gravel content in the soil, the higher the degree of improvement in the EAC value. In practical application, it is recommended to use gravel soil with low gravel content and high fiber content. Finally, a regression model considering the gravel content and fiber content was proposed for fast predicting the tensile strength of the soil. The related results can provide references for the anti-cracking design of the core wall of high ECRDS.
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Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
Inji Baek,Su Bun Jeon,Min-Ji Song,Enyue Yang,Uy Dong Sohn,In Kyeom Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300ՌM) or vehicle. We determined the phosphorylation level of the myosin light chain (MLC<sub>20</sub>), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of MLC<sub>20</sub> phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619- or NaF-induced phosphorylation of MYPT1<sup>Thr855</sup> and CPI17<sup>Thr38</sup>, the downstream effectors of Rho-kinase. In regards to the Ca<sup>2+</sup>-free solution, flavone inhibited the phosphorylation of MYPT1<sup>Thr855</sup> and CPI17<sup>Thr38</sup>, as well as vascular contractions induced by U46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.
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