Predictive V16alue of Thymidylate Synthase Expression in Gastric Cancer: A Systematic Review with Meta-analysis

Hu, Hua-Bin,Kuang, Lei,Zeng, Xiao-Min,Li, Bin,Liu, En-Yi,Zhong, Mei-Zuo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Purpose: The relationship between thymidylate synthase (TS) expression and outcomes in gastric cancer (GC) patients remains controversial, although most studies reported poor survival and reduced response to fluoropyrimidine were related to high TS in tumors. We carried out a systematic review of the literature with meta-analysis to estimate the predictive value of TS expression from published studies. Methods: We indentified 24 studies analysing the outcome data in gastric cancer stratified by TS expression. Effect measures of outcome were hazard ratios (HRs) for overall survival (OS) and event-free survival (EFS), or the odds ratio (OR) for overall response rate (ORR). HRs and ORs from these eligible studies were pooled using random-effects meta-analysis. Results: Fifteen studies investigated outcomes in a total of 844 patients with advanced GC, and nine studies investigated outcomes in a total of 1,235 patients with localized GC undergoing adjuvant therapy. Meta-analysis of estimates showed high TS expression was significantly associated with poor OS in the advanced setting (HR: 1.43, 95%CI: 1.08 - 1.90), and poor EFS in the adjuvant setting (HR: 1.53, 95%CI: 1.01 - 2.32). Subgroup analysis demonstrated TS expression to haves even greater value in predicting OS, EFS and ORR in advanced GC patients treated with fluoropyrimidine monotherapy (HR for OS: 2.32, 95%CI: 1.53 - 3.50; HR for EFS: 1.76, 95%CI: 1.19 - 2.60; OR for ORR: 0.32, 95%CI: 0.11 - 0.95). Conclusion: High levels of TS expression were asssociated with a poorer OS for advanced GC patients compared with low levels. In the adjuvant setting, high TS expression was also associated with a worse EFS. Additional studies with consistent methodology are needed to define the precise predictive value of TS.

ON THE COMPLEX VARIABILITY OF THE SUPERORBITAL MODULATION PERIOD OF LMC X-4

HU, CHIN-PING,LIN, CHING-PING,CHOU, YI,YANG, TING-CHANG,SU, YI-HAO,HSIEH, HUNG-EN,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

LMC X-4 is an eclipsing high-mass X-ray binary exhibiting a superorbital modulation with a period of ~ 30:5 days. We present a detailed study of the variations of the superorbital modulation period with a time baseline of ~ 18 years. The period determined in the light curve collected by the Monitor of All-sky X-ray Image (MAXI) significantly deviates from that observed by the All Sky Monitor (ASM) onboard the Rossi X-ray Timing Explorer (RXTE). Using the data collected by RXTE/ASM, MAXI, and the Burst Alert Telescope (BAT) onboard Swift, we found a significant period derivative, $\dot{P}=(2.08{\pm}0.12){\times}10^{-5}$. Furthermore, the O{C residual shows complex short-term variations indicating that the superorbital modulation of LMC X-4 exhibits complicated unstable behaviors. In addition, we used archive data collected by the Proportional Counter Array (PCA) on RXTE to estimate the orbital and spin parameters. The detected pulse frequencies obtained in small time segments were fitted with a circular orbital Doppler shift model. In addition to orbital parameters and spin frequency for each observation, we found a spin frequency derivative of $\dot{v}=(6.482{\pm}0.011){\times}10^{-13}Hz{\cdot}s^{-1}$. More precise orbital and spin parameters will be evaluated by the pulse arrival time delay technique in the future.

APPLICATIONS OF THE HILBERT-HUANG TRANSFORM ON THE NON-STATIONARY ASTRONOMICAL TIME SERIES

HU, CHIN-PING,CHOU, YI,YANG, TING-CHANG,SU, YI-HAO,HSIEH, HUNG-EN,LIN, CHING-PING,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

The development of time-frequency analysis techniques allow astronomers to successfully deal with the non-stationary time series that originate from unstable physical mechanisms. We applied a recently developed time-frequency analysis method, the Hilbert-Huang transform (HHT), to two non-stationary phenomena: the superorbital modulation in the high-mass X-ray binary SMC X-1 and the quasi-periodic oscillation (QPO) of the AGN RE J1034+396. From the analysis of SMC X-1, we obtained a Hilbert spectrum that shows more detailed information in both the time and frequency domains. Then, a phase-resolved analysis of both the spectra and the orbital profiles was presented. From the spectral analysis, we noticed that the iron line production is dominated by different regions of this binary system in different superorbital phases. Furthermore, a pre-eclipse dip lying at orbital phase ~0:6-0:85 was discovered during the superorbital transition state. We further applied the HHT to analyze the QPO of RE J1034+396. From the Hilbert spectrum and the O-C analysis results, we suggest that it is better to divide the evolution of the QPO into three epochs according to their different periodicities. The correlations between the QPO periods and corresponding fluxes were also different in these three epochs. The change in periodicity and the relationships could be interpreted as the change in oscillation mode based on the diskoseismology model.

Metallic Hydrogen in Atomically Precise Gold Nanoclusters

Hu, Guoxiang,Tang, Qing,Lee, Dongil,Wu, Zili,Jiang, De-en American Chemical Society 2017 Chemistry of materials Vol.29 No.11

<P>Hydrogen-metal interaction is the foundation of many technologies and processes, but how hydrogen behaves in atomically precise gold nanoclusters remains unknown even though they have been used in hydrogenation catalysis and water splitting. Herein, we investigate how hydrogen interacts with [Au-25(SR)(18)](q) dusters and mono-atom-doped bimetallic [M1Au24(SR)(18)](q) clusters (M = Pt, Pd, Ag, Cu, Hg, or Cd) from first principles. We find that hydrogen behaves as a metal in these clusters and contributes its is electron to the superatomic free-electron count. This opposite behavior compared to that of the hydride in Cu and Ag dusters allows the small hydrogen to interstitially dope the gold dusters and tune their superatomic electronic structure. The doping energetics shows that when an eight-electron superatom is formed after H doping, the binding energy of H is much stronger, while binding of H with an already eight-electron superatom is much weaker. Indeed, frontier orbitals and the HOMO-LUMO gaps of [Au25H1(SR)(18)](0), [Au25H2(SR)(18)](+) [PtAu24H2(SR)(18)](0), [PdAu24H2(SR)(18)](0), [AgAu24H(SR)(18)](0), and [CuAu24H(SR)(18)](0) all have very similar features, because they are all eight-electron superatoms. By calculating the Gibbs free energies of hydrogen adsorption, we predict that PtAu24(SR)(18), PdAu24(SR)(18), and center-doped CuAu24(SR)(18) can be good electrocatalysts for the hydrogen evolution reaction.</P>

Tracklet-Global Track Association and Fusion Methods in Distributed Sensor Networks

Fan En,Shen Shi-gen,Hu Ke-li,Yuan Chang-hong,Wang Pin 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.6

In distributed sensor networks, track association and track fusion become difficult due to the existence of various uncertainties in multiple target tracking (MTT). In an actual tracking system, state estimates of a local track are usually transmitted from local nodes to the global node by message, and each message generally contains single state estimate. Based on this fact, one can define two state estimates of a local track in continuous times as a tracklet. Then, local track-global track association can be divided into tracklet-global track (T2GT) association in real time. Hence, a T2GT association method based on Hough transform (HT-T2GT) is proposed. By Hough transform, all the tracklets in the same interval can be mapped into a set of points in Hough space, and the track association problem can be transformed as one of point clustering in Hough space. The maximum entropy fuzzy c-mean (ME-FCM) clustering method is used to realize T2GT association. In addition, a T2GT fusion method based on the support degree function (SDF-T2GT) is developed for track fusion. The experimental results illustrate that the proposed methods can respectively realize T2GT association and track fusion in the situations with multiple local nodes, reduce the average time of updating global tracks and satisfy the requirement of real-time processing in the global node. It achieves higher association processing rate than other two track association methods.

Group 부분곱을 이용한 효율적인 상수 곱셈기 설계

김용은(Yong-En Kim),이주영(Joo-Young Yi),장인걸(In-Gul Jang),허일남(Il-Nam Hu),정진균(Jin-Gyun Chung) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11

Some digital signal processing applications, such as FFT’s request multiplications with predetermined coefficient. In this paper, an efficient constant multiplier design method for pre-determined coefficient is proposed. In case of FFT design used in UWB, it is shown that by the proposed method, area, power consumption and delay time can be reduced up to 30.6%, 27.2% and 6.2%, respectively, compared with conventional CSD method.

THE ORBITAL EPHEMERIS OF THE PARTIAL ECLIPSING X-ray BINARY X1822-371

HSIEH, HUNG-EN,CHOU, YI,HU, CHIN-PING,YANG, TING-CHANG,SU, YI-HAO,LIN, CHING-PING,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

X1822-371 is a low mass X-ray binary with an accretion disk corona exhibiting partial eclipses and pulsations in the X-ray band. We update its orbital ephemeris by combining new RXTE observations and historical records, with a total time span of 34 years. There were 11 RXTE observations in 2011 but the eclipsing profile can be seen in only 4 of them. The eclipsing center times were obtained by fitting the profile with the same model as previous studies. Combined with the eclipsing center times reported by Iaria et al. (2011), the O-C analysis was processed. A quadratic model was applied to fit the O-C results and produced a mean orbital period derivative of $\dot{P}_{orb}=1.339(25){\times}10^{-10}s/s$, which is slightly smaller than previous records. In addition to the orbital modulation from the orbital profile, we also present our preliminary results for measuring the orbital parameters using the orbital Doppler effect from the pulsation of the neutron star in X1822-371. The updated orbital parameters from eclipsing profiles will be further compared with the ones from pulsar timing.

Wind Power Dispatching under Grid Transmission Constraints

He, Shi-En,Zhang, Bo-Lin,Cui, Gang,Li, Xiao-Hu The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.1

In recent years, wind power penetration into the grid increased rapidly in Jiuquan, supported by the Provincial government to "establish a 'Hexi Wind Power Corridor' and to rebuild a Western 'Terrestrial Three Gorges Dam'". Jiuquan, as part of Silk Road along Hexi Corridor in China's Gansu Province, is far away from any load centers. Wind farms in this region are connected to 110 kV or above transmission network with a weak grid configuration and the transmission passage is the bottleneck of wind power delivery. This paper studies the integration of wind power into Jiayuguan-Jiuquan (Jia-Jiu) Grid focusing on the impact on Gansu Provincial Power Grid operation. By using power system analysis software package and the latest wind turbine models the transient stability is analyzed and a Special Protection Scheme (SPS) is configured to improve the wind power delivery ability. The results show that the SPS is effective. Discussions and suggestions are also included.

A Wireless Sensor Network Clustering Algorithm based on Hypergraph

Xu Qian,Hu Ji-cheng,Lin Hai,Kong Ruo-shan,Luo Yong-en,Zhu Li,Mao Hua-qing 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.6

The paper proposes a clustering algorithm for wireless sensor network based on hypergraph. Under the hypergraph model, a wireless sensor network is mapped to a hypergraph. Then a hierarchical iterative clustering algorithm is applied to the hypergraph, thus dividing the hypergraph into multiple parts. A cluster head is selected from each part. In order to improve the partitioning process, a new modularity function is proposed. Compared with the classic clustering algorithm LEACH, simulation shows that our algorithm performs better in energy consuming and network lifetime.

Effects of Metal-Doping on Hydrogen Evolution Reaction Catalyzed by MAu₂₄ and M₂Au₃₆ Nanoclusters (M = Pt, Pd)

Choi, Woojun,Hu, Guoxiang,Kwak, Kyuju,Kim, Minseok,Jiang, De-en,Choi, Jai-Pil,Lee, Dongil American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.51

<P>This paper describes the effects of doped metals on hydrogen evolution reaction (HER) electrocatalyzed by atomically controlled MAu<SUB>24</SUB> and M<SUB>2</SUB>Au<SUB>36</SUB> nanoclusters, where M = Pt and Pd. HER performances, such as onset potential (<I>E</I><SUB>onset</SUB>), catalytic current density, and turnover frequency (TOF), are comparatively examined with respect to the doped metals. Doping Pt or Pd into gold nanoclusters not only changes the electrochemical redox potentials of nanoclusters but also considerably improves the HER activities. <I>E</I><SUB>onset</SUB> is found to be controlled by the nanocluster’s reduction potential matching the reduction potential of H<SUP>+</SUP>. The higher catalytic current and TOF are observed with the doped nanoclusters in the order of PtAu<SUB>24</SUB> > PdAu<SUB>24</SUB> > Au<SUB>25</SUB>. The same trend is observed with the Au<SUB>38</SUB> group (Pt<SUB>2</SUB>Au<SUB>36</SUB> > Pd<SUB>2</SUB>Au<SUB>36</SUB>> Au<SUB>38</SUB>). Density functional theory calculations have revealed that the hydrogen adsorption free energy (Δ<I>G</I><SUB>H</SUB>) is significantly lowered by metal-doping in the order of Au<SUB>25</SUB> > PdAu<SUB>24</SUB> > PtAu<SUB>24</SUB> and Au<SUB>38</SUB> > Pd<SUB>2</SUB>Au<SUB>36</SUB> > Pt<SUB>2</SUB>Au<SUB>36</SUB>, indicating that hydrogen adsorption on the active site of nanocluster is thermodynamically favored by Pd-doping and further by Pt-doping. The doped metals, albeit buried in the core of the nanoclusters, have profound impact on their HER activities by altering their reduction potentials and hydrogen adsorption free energies.</P> [FIG OMISSION]</BR>