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Abouzied, Mekky Mohammed,Eltahir, Heba M.,Fawzy, Michael Atef,Abdel-Hamid, Nabil Mohie,Gerges, Amany Saber,El-Ibiari, Hesham Mohmoud,Nazmy, Maiiada Hassan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Purpose: To find parameters that can increase alpha-fetoprotein (AFP) sensitivity and so help in accurate diagnosis and rapid management of hepatocullular carcinoma (HCC), as AFP has limited utility of distinguishing HCC from benign hepatic disorders for its high false-positive and false negative rates. Materials and Methods: Serum levels of AFP, 5'-nucleotidase enzyme activity (5-NU) and leucine aminopeptidase enzyme (LAP) activity were measured in 40 individuals. Results: LAP and 5'NU were elevated in HCC at p<0.001. Pearson correlation coefficients showed that changes in AFP exhibited positive correlation with both 5'-NU and LAP at (p<0.001). The complementary use of LAP only with AFP resulted in an increase in sensitivity of AFP from 75% to 90% in detecting HCC. The complementary use of both LAP and 5-NU with AFP resulted in an increased sensitivity of AFP in detecting HCC from 75% to 95%. Conclusions: LAP and 5-FU can be determined in HCC patients in combination with AFP to improve its sensitivity and decrease false negative results.
Song, Daesub,Ha, Gunwoo,Serhan, Wissam,Eltahir, Yassir,Yusof, Mohammed,Hashem, Farouq,Elsayed, Elsaeid,Marzoug, Bahaaeldin,Abdelazim, Assem,Al Muhairi, Salama American Society for Microbiology 2015 Journal of clinical microbiology Vol.53 No.4
<P>We present here a rapid immunochromatographic assay for the detection of Middle East respiratory syndrome coronavirus (MERS-CoV) antigen in the nasal swabs of dromedary camels. The assay is based on the detection of MERS-CoV nucleocapsid protein in a short time frame using highly selective monoclonal antibodies at room temperature. The relative sensitivity and specificity of the assay were found to be 93.90% and 100%, respectively, compared to that of the UpE and open reading frame 1A (Orf1A) real-time reverse transcriptase PCR (RT-PCR). The results suggest that the assay developed here is a useful tool for the rapid diagnosis and epidemiological surveillance of MERS-CoV infection in dromedary camels.</P>
Awwad A. Radwan,Kamal E. H. elTahir 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.5
The synthesis of several 4-phenyl-5-pyridin-4-yl-2,3-dihydro-3H-1,2,4-triazole-3-thiones possessing N-2Mannich bases or S-alkyl substituents, is reported. Severalof them exhibited a low nanomolar COX enzyme inhibitionactivity. Most of the compounds showed inhibition ofedema was similar to that evoked by celocoxib in animalmodel. Molecular docking studies of the compounds intothe binding sites of COX-1 and COX-2 allowed us to shedlight on the binding mode of these novel COX inhibitors.