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Awwad A. Radwan,Kamal E. H. elTahir 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.5
The synthesis of several 4-phenyl-5-pyridin-4-yl-2,3-dihydro-3H-1,2,4-triazole-3-thiones possessing N-2Mannich bases or S-alkyl substituents, is reported. Severalof them exhibited a low nanomolar COX enzyme inhibitionactivity. Most of the compounds showed inhibition ofedema was similar to that evoked by celocoxib in animalmodel. Molecular docking studies of the compounds intothe binding sites of COX-1 and COX-2 allowed us to shedlight on the binding mode of these novel COX inhibitors.