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RISS 인기검색어
- 검색키워드
- 저자 : Elizabeth Scarr (검색결과 2 건)
- 무료
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Elizabeth Scarr,Brian Dean 대한정신약물학회 2012 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.10 No.1
Objective: Given the ability of mood stabilizers and antipsychotics to promote cell proliferation, we wanted to determine the effects of these drugs on neuronal markers previously reported to be altered in subjects with psychiatric disorders. Methods: Male Sprauge-Dawley rats were treated with vehicle (ethanol), lithium (25.5 mg per day), haloperidol (0.1 mg/kg),olanzapine (1.0 mg/kg) or a combination of lithium and either of the antipsychotic drugs for 28 days. Levels of cortical synaptic (synaptosomal associated protein-25, synaptophysin, vesicle associated protein and syntaxin) and structural (neural cell adhesion molecule and alpha-synuclein) proteins were determined in each treatment group using Western blots. Results: Compared to the vehicle treated group; animals treated with haloperidol had greater levels of synaptosomal associated protein-25 (p<0.01) and neural cell adhesion molecule (p<0.05), those treated with olanzapine had greater levels of synaptophysin (p<0.01) and syntaxin (p<0.01). Treatment with lithium alone did not affect the levels of any of the proteins. Combining lithium and haloperidol resulted in greater levels of synaptophysin (p<0.01), synaptosomal associated protein-25 (p<0.01) and neural cell adhesion molecule (p<0.01). The combination of lithium and olanzapine produced greater levels of synaptophysin (p<0.01) and alpha-synuclein (p<0.05). Conclusion: Lithium alone had no effect on the neuronal markers. However, haloperidol and olanzapine affected different presynaptic markers. Combining lithium with olanzapine additionally increased alpha-synuclein. These drug effects need to be taken into account by future studies examining presynaptic and neuronal markers in tissue from subjects with psychiatric disorders.
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Potential Molecular and Cellular Mechanism of Psychotropic Drugs
Myoung Suk Seo,Brian Dean,Elizabeth Scarr,Chi-Yu Lai 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2
Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treatthese disorders, they give sub-optimal recovery in many people and a significant number of individuals do not respond to anytreatments and remain treatment resistant. Surprisingly, the mechanism by which psychotropic drugs cause their therapeuticbenefits remain unknown but likely involves the underlying molecular pathways affected by the drugs. Hence, in this review,we have focused on recent findings on the molecular mechanism affected by antipsychotic, mood stabilizing and antidepressantdrugs at the levels of epigenetics, intracellular signalling cascades and microRNAs. We posit that understanding these importantinteractions will result in a better understanding of how these drugs act which in turn may aid in considering how to developdrugs with better efficacy or increased therapeutic reach.
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