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Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins
Torres-Rojas Isabel,Pérez-Alzate Diana,Somoza Maria Luisa,Pfeifer Ana Prieto-Moreno,Diaz Elisa Haroun,Jimenez-Rodriguez Teodorikez W,Sánchez Javier Fernández,Ruano Francisco J,Blanca Miguel,Blanca-Lóp 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2
Purpose: Clavulanate, a beta-lactam associated with amoxicillin, is frequently prescribed in patients at all ages. Recent data implicate amoxicillin-clavulanate in up to 80% of beta-lactam allergy cases. We assessed clavulanate’s role in inducing allergic reactions to this combination treatment, with a focus on selective immediate reactions. Methods: Adults (≥ 16 years) reporting a history of immediate reactions to amoxicillin-clavulanate were evaluated through a beta-lactam allergological workup, using modified European Academy of Allergy and Clinical Immunology guidelines. Patients first underwent skin testing, and if negative, drug provocation tests. Expected outcomes were: Group A, subjects with immediate reaction to classical penicillin group determinants (penicilloyl polylysine, minor determinants mixture, and/or penicillin G); Group B, subjects with selective immediate reaction to amoxicillin; Group C, subjects with selective immediate reaction to clavulanate and Group D, those immediate reactions with co-sensitization to clavulanate plus penicillin group determinants or amoxicillin. Results: Of 1,170 included patients, 104 had immediate reactions: 36.5% to penicillin group determinants (Group A), 26.9% to amoxicillin (Group B), 32.7% to clavulanate (Group C), and 3.8% to clavulanate plus penicillin determinants or amoxicillin (Group D). Diagnosis was made by skin testing in 79%, 75% and 47% of the patients, respectively, in the first 3 groups (P < 0.001). Drug provocation tests were necessary to establish most other diagnoses. Anaphylaxis predominated over urticaria/angioedema in all groups. Conclusions: Selective immediate reactions to clavulanate accounted for over a third of cases with confirmed reactions after amoxicillin-clavulanate intake, with more than half experiencing anaphylaxis. Within this group, skin test sensitivity was below 50%. People taking amoxicillin-clavulanate may also be co-sensitized to both drugs.
( Edoardo Torres-guerrero ),( Elisa Crystal Sanchez-moreno ),( Carlos Enrique Atoche-dieguez ),( Erika Margarita Carrillo-casas ),( Roberto Arenas ),( Juan Xicohtencatl-cortes ),( Rigoberto Hernandez- 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
Background: The causative agents of leprosy are the well-known Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. This agent was found in 2008, and it was found to be the cause of diffuse lepromatous leprosy in two Mexican patients. Objective: The objective of this work was to determine if M. leprae and M. lepromatosis were present in formalin-fixed and paraffin- embedded skin samples from cases from different regions in Mexico. Methods: A total of 41 skin samples were obtained from 11 states of Mexico. All patients’ samples were diagnosed by clinical and histopathological analyses. Total DNA was isolated using a Qiagen-DNeasy blood and tissue kit and molecular identification was achieved by two semi-nested polymerase chain reactions. Results: The 41 patient included 33 samples from men and 8 samples from women; 29 samples were polymerase chain reaction (PCR)-positive to Mycobacterium and 12 samples were PCR-negative. From those 29 samples, 13 were PCR-positive to M. leprae, 8 to M. lepromatosis and 8 were positive to both species. The histopathological diagnosis included; Nodular lepromatous leprosy (NLL); Diffuse lepromatous leprosy (DLL); and Borderline leprosy (BL). The 29 PCR-positive samples were classified as follow: 14 NLL, 4 DLL, and 11 BL. In the 12 samples negative to Mycobacterium, 7 showed the NLL, 2 DLL and 3 BL. Conclusion: These findings add evidence to the M. leprae and M. lepromatous distribution, clinical forms and participation of dual infections in Mexico. (Ann Dermatol 30(5) 562∼565, 2018)
Effect of Acupuncture at Tender Points for the Management of Fibromyalgia Syndrome: A Case Series
Jessica Lucia Neves Bastos,Josie Resende Torres Silva,Marcelo Lourenco Silva,Fernanda Lopes Buiatti de Araujo,Elisa Do´ria Pires 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.3
Background: Affecting more women than men, fibromyalgia syndrome (FMS) is a rheumatic disorder characterized by chronic, diffuse and widespread musculoskeletal pain, and its pathogenesis is still unknown. Among the recommended treatments, acupuncture (for its analgesic effects) is an effective option for reducing the pain sensitivity and improving quality of life. Therefore, this study aimed to investigate whether acupuncture at tender points could effectively manage FMS. Methods: Eight female patients, with a previous diagnosis of fibromyalgia, underwent an initial assessment involving pressure algometer measurements for pain tolerance and questionnaires [Fibromyalgia Impact Questionnaire (FIQ), Heath Assessment Questionnaire (HAQ), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI)], followed by treatment. Over a 2-month period, acupuncture was performed once per week at five tender points, located bilaterally at the occipital bone, trapezius, rhomboid, upper chest and lateral epicondyle. At the end of treatment, the participants underwent a reassessment for a final review of the applied methods. Results: We observed a reduction in the pain threshold and sensitivity and improvement in the areas of anxiety and depression and quality of life, which were demonstrated using the FIQ, BDI and BAI but not the HAQ.
A shelf-life study of silica- and carbon-based mesoporous materials
Emma M. Björk,Aylin Atakan,Pei-Hsuan Wu,Alessandra Bari,Carlotta Pontremoli,Kai Zheng,Dimitra Giasafaki,Giorgio Iviglia,Elisa Torre,Clara Cassinelli,Marco Morra,Theodore Steriotis,Georgia Charalambopo 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
Mesoporous silica- and carbon-based materials, including bioactive glasses, have proven potential ascomponents of medical devices and as drug carriers. From an application perspective, knowledge aboutthe shelf-life stability of these materials under various conditions is vital. Here, mesoporous bioactiveglasses (MBGs) synthesized by aerosol-assisted spray-drying and by a batch sol–gel method, mesoporoussilicas of SBA-15 type, and mesoporous carbons CMK-1 and CMK-3 have been stored under varying conditions,e.g. at different temperature and relative humidity (RH), and in different storage vessels. Theresults show that the silica-based materials stored in Eppendorfs are sensitive to humidity. Spray driedMBGs decompose within 1 month at a RH >5%, whilst sol–gel MBGs are more stable up to a RH >60%. Changing the storage vessel to sealed glass flasks increases the MBGs lifetime significantly, with nodegradation during 2 months of storage at a RH = 75%. SBA-15 stored in Eppendorfs are more stable comparedto MBGs, and addition of F- ions added during the synthesis affects the material degradation rate. Mesoporous carbons are stable under all conditions for all time points. This systematic study clearlydemonstrates the importance of storage conditions for mesoporous materials which is crucial knowledgefor commercialization of these materials.
Sarabia-Sainz, Hector M.,Ezquerra-Brauer, Josafat Marina,Santacruz-Ortega, Hisila C.,Rouzaud-Sandez, Ofelia,Valenzuela-Soto, Elisa M.,Acosta-Elias, Monica,Torres-Arreola, Wilfrido 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
Muscle from mantle, fins and arms of squid (Dosidicus gigas) were compared based on lysyl oxidase activity (LOX), chemical/structural and thermodynamic properties of highly cross-linked collagen. The arms collagen presented the highest temperature (Tp) and enthalpy of transition. The arms collagen thermic properties may be explained by the higher imino amino acid content, proline and lysine hydroxylation degrees. Moreover, among the regions, the collagen from the arms had a more intense ${\beta}$ band chain, hydroxymerodesmosine peak in the resonance magnetic nuclear spectra and pyridinoline peak in the Raman spectra. Fins showed the highest LOX activity. The LOX activity was associated with the Tp, proline and lysine hydroxylation degrees. These results implied that the collagen in the arms was more intermolecularly ordered than the mantle and fins, and may provide a theoretical basis for a better understanding of the thermal behaviour of squid tissues during management and processing.
He´ctor M. Sarabia-Sainz,Josafat Marina Ezquerra-Brauer,Hisila C. Santacruz-Ortega,Ofelia Rouzaud-Sa´ndez,Elisa M. Valenzuela-Soto,Monica Acosta-Elias,Wilfrido Torres-Arreola 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
Muscle from mantle, fins and arms of squid (Dosidicus gigas) were compared based on lysyl oxidase activity (LOX), chemical/structural and thermodynamic properties of highly cross-linked collagen. The arms collagen presented the highest temperature (Tp) and enthalpy of transition. The arms collagen thermic properties may be explained by the higher imino amino acid content, proline and lysine hydroxylation degrees. Moreover, among the regions, the collagen from the arms had a more intense b band chain, hydroxymerodesmosine peak in the resonance magnetic nuclear spectra and pyridinoline peak in the Raman spectra. Fins showed the highest LOX activity. The LOX activity was associated with the Tp, proline and lysine hydroxylation degrees. These results implied that the collagen in the arms was more intermolecularly ordered than the mantle and fins, and may provide a theoretical basis for a better understanding of the thermal behaviour of squid tissues during management and processing.