Clinical and anatomic description of patients with arteriovenous malformation treated with endovascular therapy in a Mexican population

Mallyolo Eliezer Pelayo-Salazar,Héctor Alfredo Montenegro-Rosales,Jorge Luis Balderrama-Bañares,Pablo Martínez-Arellano,Omar Andrés Campos-Flota,Laura Mestre-Orozco,Julio César López-Valdés 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.1

Objective: Arteriovenous malformations (AVMs) are benign congenital lesions. The estimated prevalence is 10-18 per 100,000 individuals, with an incidence rate of 1.1-1.4 per 100,000 person-year; only 12% of AVMs present symptoms during life. It is important to study different characteristics associated with AVMs because these patients require multidisciplinary treatment. Methods: A descriptive, observational, longitudinal, and retrospective study was carried out from January 15, 2016 to October 19, 2021. Convenience sampling was used on patients diagnosed with arteriovenous malformation. Sociodemographic data was obtained, such as: sex, age, site, predominant symptoms, clinical debut, type of malformation, data associated with post therapy evolution, type of embolizing agent used, associated complications, Rankin scale, and death. Results: Data from 535 procedures was collected, we calculated an incidence of 4.4 cases per million inhabitants. Ninety procedures in 56 patients that used endovascular therapy were obtained with a female-male ratio of 0.75 and an age distribution of 35±14 (SD). A 36.3±11.5 (SD) mm diameter was registered. There was a 33% success rate for endovascular surgery. Conclusions: The multidisciplinary treatment of AVMs is made up of three pillar techniques: microsurgical resection, embolization, and radio-neurosurgery. It is extremely important to make an appropriate decision, with an emphasis on achieving better functional outcomes for the patient. Although neurological endovascular therapy was initially used as an adjuvant treatment for neurosurgery and radio-neurosurgery, it has been used more and more frequently as the first line of treatment.

The role of Si and Ca on new wrought Mg-Zn-Mn based alloy

Ben-Hamu, G.,Eliezer, D.,Shin, K.S. Elsevier Sequoia 2007 Materials science & engineering. properties, micro Vol.447 No.1

The development of new wrought magnesium alloys for automotive industry has increased in recent years due to their high potential as structural materials for low density and high strength/weight ratio demands. However, the poor mechanical properties of the magnesium alloys have led to search a new kind of magnesium alloys for better strength and ductility. Magnesium alloys show strong susceptibility to localized corrosion in chlorides solutions due to their inhomogeneous microstructure. The existence of intermetallics in the microstructure of magnesium alloys might represent initiation sites for localized corrosion. This is due to the formation of galvanic couples between the intermetallics and the surrounding matrix. The main objective of this research is to investigate the corrosion behavior of new magnesium alloys; Mg-Zn-Mn-Si-Ca (ZSMX) alloys. The ZSM6X1+YCa alloys were prepared by using hot extrusion method. AC and DC polarization tests were carried out on the extruded rods, which contain different amounts of silicon or calcium. The potential difference in air between different phases and the matrix was examined using scanning Kelvin probe force microscopy (SKPFM). The phases present in the alloys have been identified by optical microscopy and scanning electron microscopy/energy dispersive X-ray spectroscopy. Four different phases were found, i.e. intermetallics containing Si-Mn, Mg-Si, Mg-Zn and Mg-Si-Ca phase. All phases exhibited higher potential differences relative to magnesium matrix indicating a cathodic behavior. The potential difference revealed significant dependence on the chemical composition of the phases. Based on the results obtained from the scanning Kelvin probe force microscopy, the cathodic phases are effective sites for the initiation of localized corrosion in Mg-Zn-Mn-Si-Ca alloys.

Alpha-Synuclein Function and Dysfunction on Cellular Membranes

David Snead,David Eliezer 한국뇌신경과학회 2014 Experimental Neurobiology Vol.23 No.4

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of Parkinson's disease. Mutations in andalterations in expression levels of alpha-synuclein cause autosomal dominant early onset heredity forms of Parkinson's disease, andsporadic Parkinson's disease is defined in part by the presence of Lewy bodies and Lewy neurites that are composed primarily ofalpha-synuclein deposited in an aggregated amyloid fibril state. The normal function of alpha-synuclein is poorly understood, andthe precise mechanisms by which it leads to toxicity and cell death are also unclear. Although alpha-synuclein is a highly soluble,cytoplasmic protein, it binds to a variety of cellular membranes of different properties and compositions. These interactions areconsidered critical for at least some normal functions of alpha-synuclein, and may well play critical roles in both the aggregationof the protein and its mechanisms of toxicity. Here we review the known features of alpha-synuclein membrane interactions in thecontext of both the putative functions of the protein and of its pathological roles in disease.

Corrosion of New Wrought Magnesium Alloys

Na, Young Gee,Eliezer, Dan,Shin, Kwang Seon Trans Tech Publications, Ltd. 2005 Materials science forum Vol.488 No.-

<P>The development of new components with magnesium alloys for the automotive industry has increased in recent years due to their high potential as structural materials for low density and high strength/weight ratio demands. However, the limited mechanical properties of the magnesium alloys have led to search new kind of magnesium alloys for better strength and ductility. The main objective of this research is to investigate the mechanical properties and the corrosion behavior of new wrought magnesium alloys; Mg-Zn-Ag (ZQ) and Mg-Zn-Si (ZS) alloys. The ZQ6X and ZS6X samples were fabricated using hot extrusion method. Tensile tests and immersion tests were carried out on the specimens from the extruded rods, which contained different amounts of silver or silicon, in order to evaluate the mechanical properties and corrosion behavior. The microstructure was examined using optical and electron microscopy (TEM and SEM) and EDS. The results showed that the addition of silver improved the mechanical properties but decreased the corrosion resistance. The addition of silicon improved both mechanical properties and corrosion resistance. These results can be explained by the effects of alloying elements on the microstructures of the Mg-Zn alloys such as grain size and precipitates caused by the change in precipitation and recrystallization behavior.</P>

Impact of Acupuncture Intervention on the Pain Intensity of Patients Treated at a Tertiary Hospital in Brazil

Natália F. Valente,Eliezer de Sousa Cardoso,Juliana A. da Silva Rezende,Jeferson A. Santos 사단법인약침학회 2020 Journal of Acupuncture & Meridian Studies Vol.13 No.5

Background: Nowadays, in western societies, acupuncture is widely used over the control of pain and this analgesic approach is still the most studied aspect of acupuncture. Several studies have shown that most patients go through a significant pain decrease soon after the first sessions of acupuncture. Objectives: This research has as a goal the evaluation on the effect of acupuncture treatment regarding the relief of pain intensity of different etiologies, through the visual analog scale. Methods: This research constitutes a retrospective, descriptive study, carried out with 449 patients attended in the Institute Hospital de Base of the Federal District, in Brasilia citye Brazil. Every data was gathered from our own form, with detailed clinical history which included age, marital status, work activity, reason for referral to acupuncture, main and secondary complaints, pain intensity evaluated by the Visual Analog Scale (VAS), number of sessions completed and drug therapy. All data was organized in the Microsoft Excel and processed in the Statistical Package for the Social Sciences (SPSS), version 20.0. Results: Regarding the main complaint, the mean pain decreased from 7.3 (initial VAS) to 3.2 (final VAS), a reduction that meant more than 50% relief in pain intensity. This 50% reduction in initial pain was also observed in secondary complaints (initial VAS = 6.5 and final VAS = 3.1). Conclusions: The results of this research suggest that acupuncture treatment was effective in relieving pain intensity, providing a 50% reduction on the visual analogue scale, in relation to painful complaints of different etiologies.

NONLINEAR WAVE PACKET EVOLUTION IN SHALLOW WATER

Efim Pelinovsky,타타냐타리포바,Eliezer Kit,Ori Eitan 한국해안해양공학회 1999 학술강연회 발표논문초록집 Vol.2 No.1

Wave group evolution in shallow water of constant depth is simulated numerically applying the Korteweg-de Vries equation. Decomposition into harmonics is performed and the results are presented separately for the carrier wave frequency, the 2^(nd) and the low harmonics. Experiments are performed for three values of the forcing amplitude at the wavemaker. The effect of the nonlinearity parameter and its ratio to the dispersion parameter on the evolution of the wave group along the tank is studied. Advantage is taken of the relatively simple theoretical model employed in order to analyse the relative importance of various terms in the governing equation. Good agreement between the available experimental and the numerical results is obtained.

Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies

권소민,Michiyo Iba,Eliezer Masliah,Changyoun Kim 한국뇌신경과학회 2019 Experimental Neurobiology Vol.28 No.5

Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In this review, we consolidate our key findings and recent studies concerning the role of Toll-like receptor 2 (TLR2), a pattern recognition innate immune receptor, in the pathogenesis of synucleinopathies. First, we address the pathological interaction of α-syn with microglial TLR2 and its neurotoxic inflammatory effects. Then, we show that neuronal TLR2 activation not only induces abnormal α-syn accumulation by impairing autophagy, but also modulates α-syn transmission. Finally, we demonstrate that administration of a TLR2 functional inhibitor improves the neuropathology and behavioral deficits of a synucleinopathy mouse model. Altogether, we present TLR2 modulation as a promising immunotherapy for synucleinopathies.

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

김창윤,이승재,이혜진,Eliezer Masliah 한국뇌신경과학회 2016 Experimental Neurobiology Vol.25 No.3

Synucleinopathies are a collection of neurological diseases that are characterized by deposition of α-synuclein aggregates in neurons and glia. These diseases include Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. Although it has been increasingly clear that α-synuclein is implicated in the pathogenesis of PD and other synucleinopathies, the precise mechanism underlying the disease process remains to be unraveled. The past studies on how α-synuclein exerts pathogenic actions have focused on its direct, cell-autonomous neurotoxic effects. However, recent findings suggested that there might be indirect, non-cell-autonomous pathways, perhaps through the changes in glial cells, for the pathogenic actions of this protein. Here, we present evidence that α-synuclein can cause neurodegeneration through a non-cell-autonomous manner. We show that α-synuclein can be secreted from neurons and induces inflammatory responses in microglia, which in turn secreted neurotoxic agents into the media causing neurodegeneration. The neurotoxic response of microglia was mediated by activation of toll-like receptor 2 (TLR2), a receptor for neuron-derived α-synuclein. This work suggests that TLR2 is the key molecule that mediates non-cell-autonomous neurotoxic effects of α-synuclein, hence a candidate for the therapeutic target.

Corrosion Mechanisms of New Wrought Mg-Zn Based Alloys Alloying with Si, Ca and Ag

( G. Ben Hamu ),( D. Eliezer ),( K. S. Shin ),( L. Wagner ) 한국부식방식학회(구 한국부식학회) 2008 Corrosion Science and Technology Vol.7 No.3

Increesed Ipsilateral Lung Cancer following Radiation Therapy for Breast Cancer

( Alfred I . Neugut,Eliezer Robinson,Won Chul Lee,Todd Murray,Kevin Kauwoski,Gerald J . Kutcher ) 대한보건협회 1992 대한보건협회 보건종합학술대회 Vol.- No.-