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      • KCI등재

        A New Hybrid Friction Damper (HFD) for Dual-Level Performance of Steel Structures

        Babak Shahbazi,Elham Moaddab 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

        In this study, a new hybrid energy dissipation device is developed by combining two friction dampers (auxiliary and main fuse) in series to be used for the seismic control of two diff erent earthquake intensities. Compared with the conventional friction dampers, the new hybrid damper has an advantage in that only the auxiliary fuse (with low sliding force) is activated for moderate earthquakes and both fuses work simultaneously for strong earthquakes. Cyclic loading tests of the combined hybrid dampers are carried out to evaluate their seismic energy dissipation capability. The obtained experimental force displacement indicates proper details of the new damper to create two performance levels. Finite element analyses of the test specimens are also carried out for comparison and have good agreement with the test results. Force–displacement characteristics, energy dissipation, and equivalent viscous damping are also derived and good agreement has been found. Moreover, it is demonstrated that by engaging the main fuse with non-loaded pretension bolts, the strength losses of the hybrid damper in the subsequent cycles are limited compared with the common friction dampers, which can be called the “resurrectiontype” behavior of the main fuse in the main shocks. To evaluate the eff ects of the proposed damper, typical 3- and 9-story steel buildings are modeled and their seismic responses under 22 earthquake excitations are investigated using incremental dynamic nonlinear time-history. Comparison of incremental dynamic analysis (IDA) curves and their medians revealed that using a hybrid friction damper (HFD) reduces the probability of reaching all the defi ned damage states. Moreover, the reduction eff ect of HFD was recognizable in 9-story frames.

      • Manganese Superoxide Dismutase (MnSOD Val-9Ala) Gene Polymorphism and Susceptibility to Gastric Cancer

        Moradi, Mohammad-Taher,Yari, Kheirollah,Rahimi, Zohreh,Kazemi, Elham,Shahbazi, Mehrdad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Background: Oxidative stress caused by the generation of reactive oxygen species plays an important role in human carcinogenesis. Manganese superoxide dismutase (MnSOD) Val-9Ala in the mitochondrial target sequence is the best known polymorphism of this enzyme. The purpose of the current research was to assess the association of MnSOD Val-9Ala genotypes with the risk of gastric cancer. Materials and Methods: This case-control study covered 54 gastric cancer patients compared to 100 cancer free subjects as controls. Extraction of DNA was performed on bioptic samples and genotypes were identified with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequencies of MnSOD Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 24.3, 66.7 and 9%, respectively. However, in gastric cancer patients, Ala/Ala, Ala/Val and Val/Val were observed in 24.0, 48.0 and 28.0% (p=0.01). In patients the frequency of MnSOD Val allele was higher (52%) compared to that in controls (42%). Conclusions: The results of this study show a positive association between MnSOD Val-9Ala gene polymorphism and risk of gastric cancer disease in Iranian population.

      • KCI등재

        Impact of Metabolic Syndrome on Response to Medical Treatment of Benign Prostatic Hyperplasia

        Ali Cyrus,Ali Kabir,Davood Goodarzi,Afsaneh Talaei,Ali Moradi,Mohammad Rafiee,Mehrdad Moghimi,Elham Shahbazi,Elaheh Farmani 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.12

        Purpose: To investigate the effect of metabolic syndrome (MetS) on the response to medicaltherapy of benign prostatic hyperplasia (BPH) after a 3-month period of treatment. Materials and Methods: This was a cohort study of 100 patients, 47 with MetS and 53without MetS, referred to either the primary care unit or referral hospital with BPHwho had moderate lower urinary tract symptoms of prostate involvement and were candidatesfor medical treatment. Our main outcome was response to medical treatmentwith prazosin 1 mg twice a day and finasteride 5 mg daily in patients with BPH on thebasis of International Prostate Symptom Score (IPSS). Multivariate analysis of covariancewas used to compare BPH treatment response in patients with and withoutMetS before and after receiving treatment. Results: The mean volume of the prostate was significantly higher in MetS patientsthan in patients without MetS (57±32.65 mL compared with 46.00±20.19 mL, p=0.036). The control group demonstrated an 11-unit reduction in IPSS, whereas those with MetSshowed a reduction in the symptom score of only 6 units (p<0.001). Regarding the componentsof MetS separately, triglyceride (p<0.001), fasting blood sugar (p=0.001), andwaist circumference (p=0.028) significantly affected the clinical progression of BPH. The observational nature of this study may be a limitation in comparison with an interventionalstudy. Conclusions: The results of the present study showed that MetS can negatively affectthe response to medical treatment of BPH. Therefore, it is necessary to consider MetSin selecting patients with BPH for drug therapy.

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