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RISS 인기검색어
- 검색키워드
- 저자 : Afsaneh Talaei (검색결과 2 건)
- 무료
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Effects of Platelet-Rich Plasma on Kidney Regeneration in Gentamicin-Induced Nephrotoxicity
Abbas Moghadam,,Tahereh Talaei-Khozani,Afsaneh Mafi,Mohammad Reza Namavar,Farzaneh Dehghani 대한의학회 2017 Journal of Korean medical science Vol.32 No.1
Platelet-rich plasma (PRP) as a source of growth factors may induce tissue repairing and improve fibrosis. This study aimed to assess the effects of PRP on kidney regeneration and fibrosis in gentamicin (GM)-induced nephrotoxicity rat model by stereological study. Thirty-two male rats were selected. Nephrotoxicity was induced in animals by administration of GM (80 mg/kg/daily, intraperitoneally [IP], 8 day) and animals were treated by PRP (100 µL, intra-cortical injection using surgical microscopy, single dose). Blood samples were collected for determine blood urea nitrogen (BUN) and creatinine (Cr) before and after PRP therapy. At the end of experiment, right kidneys were sectioned by Isotropic Uniform Random (IUR) method and stained with H & E and Masson’s Trichrome. The stereological methods were used for estimating the changes in different structures of kidney. PRP increased the number of epithelial cells in convoluted tubules, and decreased the volume of connective tissue, renal corpuscles and glomeruli in GM-treated animals (P < 0.05). Our findings indicate that PRP had beneficial effects on proliferation of epithelial cells in convoluted tubules and ameliorated GM-induced fibrosis.
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Impact of Metabolic Syndrome on Response to Medical Treatment of Benign Prostatic Hyperplasia
Ali Cyrus,Ali Kabir,Davood Goodarzi,Afsaneh Talaei,Ali Moradi,Mohammad Rafiee,Mehrdad Moghimi,Elham Shahbazi,Elaheh Farmani 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.12
Purpose: To investigate the effect of metabolic syndrome (MetS) on the response to medicaltherapy of benign prostatic hyperplasia (BPH) after a 3-month period of treatment. Materials and Methods: This was a cohort study of 100 patients, 47 with MetS and 53without MetS, referred to either the primary care unit or referral hospital with BPHwho had moderate lower urinary tract symptoms of prostate involvement and were candidatesfor medical treatment. Our main outcome was response to medical treatmentwith prazosin 1 mg twice a day and finasteride 5 mg daily in patients with BPH on thebasis of International Prostate Symptom Score (IPSS). Multivariate analysis of covariancewas used to compare BPH treatment response in patients with and withoutMetS before and after receiving treatment. Results: The mean volume of the prostate was significantly higher in MetS patientsthan in patients without MetS (57±32.65 mL compared with 46.00±20.19 mL, p=0.036). The control group demonstrated an 11-unit reduction in IPSS, whereas those with MetSshowed a reduction in the symptom score of only 6 units (p<0.001). Regarding the componentsof MetS separately, triglyceride (p<0.001), fasting blood sugar (p=0.001), andwaist circumference (p=0.028) significantly affected the clinical progression of BPH. The observational nature of this study may be a limitation in comparison with an interventionalstudy. Conclusions: The results of the present study showed that MetS can negatively affectthe response to medical treatment of BPH. Therefore, it is necessary to consider MetSin selecting patients with BPH for drug therapy.
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