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- 저자 : Elaine C. Gavioli (검색결과 1 건)
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Paulo R. Barbosa,Samira S. Valvassori,Celso L. Bordignon Jr.,Virginia D. Kappel,M?rcio R. Martins,Elaine C. Gavioli,Jo?o Quevedo,Fl?vio H. Reginatto 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Several species of Passiflorahave been employed widely as a folk medicine because of sedative and tran-quillizer activities. In this study, we evaluate the effects on anxiety and memory process of two popularly used Passifloraspecies. To this aim, male Wistar rats (weighing 250300 g) were intraperitoneally injected with the aqueous extract of Pas-siflora alataor Passiflora edulis(25, 50, 100, or 150 mg/kg; single injection) 30 minutes prior to the elevated plus-maze test,inhibitory avoidance test, or habituation to an open-field apparatus. The effects of both species of Passiflorawere comparedwith that of diazepam (1 mg/kg), a standard anxiolytic drug. Our findings revealed that, similar to diazepam, the treatmentwith P. alata(100 and 150 mg/kg) and P. edulis(50, 100, and 150 mg/kg) induced anxiolytic-like effects in rats. Memorywas not affected by the treatment with any dose of P. alataor P. edulis, but diazepam disrupted memory process in rats. Phy-tochemical analysis showed that the content of flavonoids of the aqueous extract of P. edulisis almost twice that of P. alata.These differences in contents of flavonoids could explain the lower active doses of the aqueous extract of P. edulisin induc-ing anxiolytic-like effects compared to P. alata. In conclusion, our findings suggest that, distinct from diazepam, the aque-ous extract of both species of Passiflorainduced anxiolytic-like effects in rats without disrupting memory process.
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