Synthesis of Hydrazone Derivatives of 4-(2-Chloroethyl) semicarbazide : A New Class of Cytotoxic Agents

El-Sabbagh, O.I.,El-Sadek, M.E.,Aboukull, M.E.,Shallal, H.M. Korean Chemical Society 2009 대한화학회지 Vol.53 No.1

새로운 종류의 히드라존 유도체는 4-(2-chloroethyl) semicarbazides로 부터 합성되었고, 인간 두 뇌(U251)와 간(Hepg2)의 암세포 에 대해 항증식성을 보였다. 히드라존 화합물은 벤즈알데히드, 아세토 페논, 3-formylindole 유도체이다. 아세토페논 유도체중에 3e (p-methoxy substituted)와 and 3f (p-nitro substituted)는 Hepg2 세포 (각각I$C_{50}$ = 6 ,8 $\mu$g/mL) 에 대해 가장 높은 세포독성활성을 보인다. 3-Formylindole 유도체중에 4a (hydrazone of 3-formylindole)은 U251 (I$C_{50}$ = 21 $\mu$g/mL)와 Hepg2 (I$C_{50}$ = 7 $\mu$g/mL)에 강한 세포독성활성을 보인다. A new series of hydrazone derivatives were synthesized from 4-(2-chloroethyl)semicarbazide and their antiproliferative activity against human brain (U251) and liver (Hepg2) carcinoma cell lines were evaluated. The hydrazone compounds are benzaldehyde (2a-2g), acetophenone (3a-3f), and 3-formylindole derivatives (4a-4d). Among the acetophenone derivatives, 3e (p-methoxy substituted) and 3f (p-nitro substituted) showed the highest cytotoxic activity against Hepg2 cell line (I$C_{50}$ = 6 and 8 $\mu$g/ml, respectively). Among the 3-formylindole derivatives, 4a (hydrazone of 3-formylindole itself) showed a pronounced cytotoxic activity against both U251 (I$C_{50}$ = 21 $\mu$g/ml) and Hepg2 (I$C_{50}$ = 7 $\mu$g/ml).

Synthesis and Pharmacological Studies for New Benzotriazole and Dibenzodiazepine Derivatives as Antipsychotic Agents

El-Sabbagh, Osama I.,El-Nabtity, Sameh M. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7

New benzotriazoles (5-8) or dibenzodiazepine derivatives (11-18) were synthesized starting from 3-[(2-amino- 4,5-disubstitutedphenyl)amino]-5,5-disubstitutedcyclohex-2-enones (1-4) through internal coupling of their diazonium salts or internal Mannich reaction in the presence of aromatic aldehydes. Pharmacological evaluation of benzotriazole and dibenzodiazepine derivatives for their clozapine-like properties revealed that dibenzodiazepine 11 bearing 4-bromophenyl group exhibited the same antipsychotic activity as the reference drug clozapine while the activity of benzotriazole 7 was 25% lesser than that of clozapine. Moreover, compounds 7 and 11 did not show significant CNS depressant activity as well as no or slight neurotoxicity on contrast to clozapine when tested in mice using forced swim, rotarod and horizontal screen tests.

THE PAINLEVE' PROPERTY, COMPLETE INTERGRABILITY AND BÄCKLUND TRANSFORMATIONS FOR A FAMILY OF LIOUVILLE EQUATIONS

El-Sabbagh, M.F.,Khater, A.H. Department of Mathematics 1989 Kyungpook mathematical journal Vol.29 No.1

Taphonomy and paleoecology of Cenomanian oysters from the Musabaa Salama area, southwestern Sinai, Egypt

Ahmed El-Sabbagh,Heba Mansour,Magdy El-Hedeny 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.4

This work is a taphonomic and paleoecologic study of Cenomanian oysters from the Musabaa Salama area, southwestern Sinai, Egypt. Disarticulation, fragmentation, encrustation and bioerosion are considered as the most predominant taphonomic features recorded in the studied oyster assemblages. Their distribution and frequency are greatly varied within the shells of the same species, as well as between shells of different species through the recorded oyster zones. Bioerosion structures include Tiers D, E, F, G and H. The multivariate statistical analyses document some characteristic ichnocoenoses. They include a sponge-dominated community (Entobia ichnocoenosis), a bivalve-dominated community (Gastrochaenolites ichnocoenosis), a serpulid-polychaete-dominated community (Maeandropolydora, Trypanites and/or Caulostrepsis ichnocoenosis), and an acrothoracican cirriped-dominated community (Rogerella ichnocoenosis). With rare exceptions, E. cretacea, G. torpedo and M. decipiens are common to abundant ichnospecies (>43%). E. ovula, E. retiformis and R. pattei are frequent to common ichnospecies (>5%). Other ichnospecies, including C. cretacea, G. orbicularis, T. solitarius, E. geometrica and C. taeniola are rare to frequent (<3%). Careful investigation of the host shells and the preserved encrusters and/or bioerosion sculptures provided data concerning the substrate characteristics, time of encrustation and bioerosion, rate of sedimentation, nutrients availability, and the general bathymetry and the rate of transgression.

Synthesis and Pharmacological Studies for New Benzotriazole and Dibenzodiazepine Derivatives as Antipsychotic Agents

Osama I. El-Sabbagh,Sameh M. El-Nabtity 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.7

New benzotriazoles (5-8) or dibenzodiazepine derivatives (11-18) were synthesized starting from 3-[(2-amino-4,5-disubstitutedphenyl)amino]-5,5-disubstitutedcyclohex-2-enones (1-4) through internal coupling of their diazonium salts or internal Mannich reaction in the presence of aromatic aldehydes. Pharmacological evaluation of benzotriazole and dibenzodiazepine derivatives for their clozapine-like properties revealed that dibenzodiazepine 11 bearing 4-bromophenyl group exhibited the same antipsychotic activity as the reference drug clozapine while the activity of benzotriazole 7 was 25% lesser than that of clozapine. Moreover, compounds 7 and 11 did not show significant CNS depressant activity as well as no or slight neurotoxicity on contrast to clozapine when tested in mice using forced swim, rotarod and horizontal screen tests.

Revascularization for Left Main and Multivessel Coronary Artery Disease: Current Status and Future Prospects after the EXCEL and NOBLE Trials

Mohammed Al-Hijji,Abdallah El Sabbagh,David R Holmes Jr 대한심장학회 2018 Korean Circulation Journal Vol.48 No.6

Revascularization of severe left main and multivessel coronary artery disease has been shown to improve survival in both stable ischemic heart disease and acute coronary syndrome. While revascularization with coronary artery bypass surgery for these disease entities carries class I recommendation in most current guidelines, recent trials has shown potential comparable survival and cardiovascular outcomes between percutaneous and surgical interventions in patients with less complex coronary anatomy. Despite the conflicting results observed in the most recent left main revascularization trials, Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease (EXCEL) and Nordic-Baltic-British left main revascularization (NOBLE), both treatment strategies remain important for the management of left main disease (LMD) and multivessel disease (MVD) reflecting on the importance of heart team discussion. This review is focused on revascularization of LMD and MVD in patients who are not presenting with ST-segment elevation myocardial infarction, encompassing the evidence from historic and contemporary trials which shaped up current practices. This review discusses the heart team approach to guide decision making, including special populations that are not represented in clinical trials.

Three-Dimensional Evaluation of Skeletal Stability following Surgery-First Orthognathic Approach: Validation of a Simple and Effective Method

Mansour Nabil M.,Abdelshaheed Mohamed E.,El-Sabbagh Ahmed H.,El-Din Ahmed M. Bahaa,Kim Young Chul,Choi Jong-Woo 대한성형외과학회 2023 Archives of Plastic Surgery Vol.50 No.3

Background The three-dimensional (3D) evaluation of skeletal stability after orthognathic surgery is a time-consuming and complex procedure. The complexity increases further when evaluating the surgery-first orthognathic approach (SFOA). Herein, we propose and validate a simple time-saving method of 3D analysis using a single software, demonstrating high accuracy and repeatability.Methods This retrospective cohort study included 12 patients with skeletal class 3 malocclusion who underwent bimaxillary surgery without any presurgical orthodontics. Computed tomography (CT)/cone-beam CT images of each patient were obtained at three different time points (preoperation [T0], immediately postoperation [T1], and 1 year after surgery [T2]) and reconstructed into 3D images. After automatic surface-based alignment of the three models based on the anterior cranial base, five easily located anatomical landmarks were defined to each model. A set of angular and linear measurements were automatically calculated and used to define the amount of movement (T1–T0) and the amount of relapse (T2–T1). To evaluate the reproducibility, two independent observers processed all the cases, One of them repeated the steps after 2 weeks to assess intraobserver variability. Intraclass correlation coefficients (ICCs) were calculated at a 95% confidence interval. Time required for evaluating each case was recorded.Results Both the intra- and interobserver variability showed high ICC values (more than 0.95) with low measurement variations (mean linear variations: 0.18 mm; mean angular variations: 0.25 degree). Time needed for the evaluation process ranged from 3 to 5 minutes.Conclusion This approach is time-saving, semiautomatic, and easy to learn and can be used to effectively evaluate stability after SFOA.

Gluteal Region Reshaping of Massive Weight Loss Patients—A Decision-Making Strategy

Mohamed Ali Mahgoub,Ahmed Mahmoud Zeina,Ahmed Mohamed Bahaa El-Din,Ahmed Hassan El-Sabbagh,Franco Bassetto,Vincenzo Vindigni 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.3

Background Massive weight loss (MWL) is a very common presentation that you may face as a plastic surgeon. Each patient has his own individual criteria, so, you should work according to a well-organized plan, especially when such cases have concerns about their gluteal area contour that were neglected before by many surgeons. A decision-making strategy was used to give a personalized treatment for targeting gluteal region reshaping of MWL patients. Methods This study considered all patients with MWL subjected to buttock reshaping. There was no randomization in treatment; there was a case-by-case assessment. We analyzed the features of the buttocks, the type of surgery performed, the outcomes, and the complications. Results Fifty two patients were included (41 females and 11 males), ages ranged between 21 and 66 years. Demographic data, preoperative body mass index (BMI), duration of surgery, type of surgery, and postoperative complications were collected. Statistically significant improvements were observed in gluteal ptosis and patient satisfaction grades. Conclusion Aesthetic improvement of the buttocks involves either augmentation or contouring that may be obtained by liposculpture, surgical lifting, or combination. Patients with MWL have high expectations and are often treated with multiple procedures. Thus, an easy strategic approach personalized on each patient to treat multiple adjacent areas in one operation is necessary. Adipose tissue distribution, gluteal skin status, and BMI were the main factors that can forcefully affect our plan to guarantee reduction of unpleasant results and complications and improve patient satisfaction.