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RISS 인기검색어
- 검색키워드
- 저자 : Ehsan Ghayour Karimani (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
Mohammad Mehdi Akbarin,Abbas Shirdel,Alireza Bari,Seyedeh Tahereh Mohaddes,Houshang Rafatpanah,Ehsan Ghayour Karimani,Kobra Etminani,Amin Golabpour,Reza Torshizi 대한혈액학회 2017 Blood Research Vol.51 No.2
Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prog-nosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL. Methods: Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR. Results: Significant differences in the mean expression levels of TAX and HBZ were observed be-tween the two study groups (ATLL and AC, P=0.014 and P=0.000, respectively). In addi-tion, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P=0.047). Conclusion: The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prog-nosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
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Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
Mohammad Mehdi Akbarin,Abbas Shirdel,Alireza Bari,Seyedeh Tahereh Mohaddes,Houshang Rafatpanah,Ehsan Ghayour Karimani,Kobra Etminani,Amin Golabpour,Reza Torshizi 대한혈액학회 2017 Blood Research Vol.52 No.2
Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prog-nosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL. Methods: Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR. Results: Significant differences in the mean expression levels of TAX and HBZ were observed be-tween the two study groups (ATLL and AC, P=0.014 and P=0.000, respectively). In addi-tion, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P=0.047). Conclusion: The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prog-nosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
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