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      • KCI등재

        Determinants of the willingness of the general population to get vaccinated against COVID-19 in a developing country

        Abdel-Hameed Al-Mistarehi,Khalid A. Kheirallah,Ahmed Yassin,Safwan Alomari,Maryam K. Aledrisi,Ehab M. Bani Ata,Nouran H. Hammad,Asim N. Khanfar,Ali M. Ibnian,Basheer Y. Khassawneh 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.2

        Purpose: Vaccination is a cost-efficient intervention to slow the spread of the coronavirus disease 2019 (COVID-19) pandemic. This study aims to assess the population’s willingness to take the COVID-19 vaccine in Jordan and investigate potential determinants of their acceptance. Materials and Methods: This study used an online survey distributed in November 2020, before introducing the vaccine, with items investigating socio-demographic characteristics, seasonal flu vaccination history, COVID-19 vaccine acceptance once available, and factors affecting their decision-making. Also, “COVID-19 risk perception” and beliefs toward COVID-19 vaccine benefits and barriers were assessed. Results: A total of 2,208 participants completed the survey with a participation rate of 13.1%. The mean±standard deviation age was 33.2±13.5, and 55.7% were females. Study participants were almost equally distributed between willingness, unwillingness, and indecision to take the COVID-19 vaccine (30.4%, 36.4%, and 31.5%, respectively). Younger adults, males, and those who were not married, do not have children, have a bachelor or higher education, employees or being students, healthcare workers, and those who reported receiving flu vaccine had higher rates of COVID-19 vaccine acceptance compared to their counterparts (p<0.001 for each category). COVID-19 risk perception, and perceived vaccine benefits, and barriers were significant predictors of intention. Among those undecided or unwilling to take the COVID-19 vaccine, its safety and side effects were the most common concerns. Conclusion: The low rate of COVID-19 vaccine acceptance in a developing country is alarming, and a significant proportion are indecisive. Interventions to elevate vaccine acceptance by addressing its safety and efficacy and targeting vulnerable groups are recommended.

      • Behaviour of high strength concrete-filled short steel tubes under sustained loading

        Saad Younas,Dongxu Li,Ehab Hamed,Brian Uy 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.39 No.2

        Concrete filled steel tubes (CFSTs) are extensively used in a variety of structures due to their structural and economic advantages over other types of structures. Considerable research has been conducted with regards to their short-term behaviour, and very limited studies have focused on their long-term behaviour. In this study, a series of tests were carried out on high strength squat (short) CFSTs and concrete cylinders under controlled conditions of temperature and humidity to better understand their time dependent behaviour. A number of parameters were investigated including the influence of steel and concrete bond, confinement, level of sustained load and sizes of specimens. The results revealed that creep strains increased by more than 40% if there was no bonding between steel tube and concrete core. As expected, creep and shrinkage of concrete inside a steel tube were significantly less than those developed in exposed concrete. At the end of a creep period of six months, all the specimens were tested to failure to observe the influence of sustained loads on the ultimate strength. It was found that creep does not have a major effect on the strength of short CFSTs in the specific experimental study conducted here, which was less than 2.5%.

      • KCI등재

        Screening of SHOX gene sequence variants in Saudi Arabian children with idiopathic short stature

        Abdulla A. Alharthi,Ehab I. El-Hallous,Iman M. Talaat,Hamed A. Alghamdi,Matar I. Almalki,Ahmed Gaber 대한소아청소년과학회 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.10

        Purpose: Short stature affects approximately 2%–3% of children, representing one of the most frequent disorders for which clinical attention is sought during childhood. Despite assumed genetic heterogeneity, mutations or deletions in the short stature homeobox-containing gene (SHOX) are frequently detected in subjects with short stature. Idiopathic short stature (ISS) refers to patients with short stature for various unknown reasons. The goal of this study was to screen all the exons of SHOX to identify related mutations. Methods: We screened all the exons of SHOX for mutations analysis in 105 ISS children patients (57 girls and 48 boys) living in Taif governorate, KSA using a direct DNA sequencing method. Height, arm span, and sitting height were recorded, and subischial leg length was calculated. Results: A total of 30 of 105 ISS patients (28%) contained six polymorphic variants in exons 1, 2, 4, and 6. One mutation was found in the DNA domain binding region of exon 4. Three of these polymorphic variants were novel, while the others were reported previously. There were no significant differences in anthropometric measures in ISS patients with and without identifiable polymorphic variants in SHOX. Conclusion: In Saudi Arabia ISS patients, rather than SHOX, it is possible that new genes are involved in longitudinal growth. Additional molecular analysis is required to diagnose and understand the etiology of this disease.

      • SCOPUSKCI등재

        Screening of SHOX gene sequence variants in Saudi Arabian children with idiopathic short stature

        Alharthi, Abdulla A.,El-Hallous, Ehab I.,Talaat, Iman M.,Alghamdi, Hamed A.,Almalki, Matar I.,Gaber, Ahmed The Korean Pediatric Society 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.10

        Purpose: Short stature affects approximately 2%-3% of children, representing one of the most frequent disorders for which clinical attention is sought during childhood. Despite assumed genetic heterogeneity, mutations or deletions in the short stature homeobox-containing gene (SHOX ) are frequently detected in subjects with short stature. Idiopathic short stature (ISS) refers to patients with short stature for various unknown reasons. The goal of this study was to screen all the exons of SHOX to identify related mutations. Methods: We screened all the exons of SHOX for mutations analysis in 105 ISS children patients (57 girls and 48 boys) living in Taif governorate, KSA using a direct DNA sequencing method. Height, arm span, and sitting height were recorded, and subischial leg length was calculated. Results: A total of 30 of 105 ISS patients (28%) contained six polymorphic variants in exons 1, 2, 4, and 6. One mutation was found in the DNA domain binding region of exon 4. Three of these polymorphic variants were novel, while the others were reported previously. There were no significant differences in anthropometric measures in ISS patients with and without identifiable polymorphic variants in SHOX. Conclusion: In Saudi Arabia ISS patients, rather than SHOX, it is possible that new genes are involved in longitudinal growth. Additional molecular analysis is required to diagnose and understand the etiology of this disease.

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