Chemopreventive and metabolic effects of inulin on colon cancer development

Emília Hijová,Viktória Szabadosova,Jana Štofilová,Gabriela Hrčková 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.4

Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4 months old) were experimentally treated with procarcinogen dimethylhydrazine to induce colon cancer development. The rats were randomly assigned to three groups: a control group (CG), a group treated with dimethylhydrazine (DMH), and a group given DMH and inulin, a prebiotic (DMH+PRE). The effects of inulin on the activities of bacterial glycolytic enzymes, short-chain fatty acids, coliform and lactobacilli counts, cytokine levels, and cyclooxygenase-2 (COX-2) and transcription nuclear factor kappa beta (NFκB) immunoreactivity were measured. Inulin significantly decreased coliform counts (p < 0.01), increased lactobacilli counts (p < 0.001), and decreased the activity of β-glucuronidase (p < 0.01). Butyric and propionic concentrations were decreased in the DMH group. Inulin increased its concentration that had been reduced by DMH. Inulin decreased the numbers of COX-2- and NFκB-positive cells in the tunica mucosae and tela submucosae of the colon. The expression of IL-2, TNFα, and IL-10 was also diminished. This 28-week study showed that dietary intake of inulin prevents preneoplastic changes and inflammation that promote colon cancer development. Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4 months old) were experimentally treated with procarcinogen dimethylhydrazine to induce colon cancer development. The rats were randomly assigned to three groups: a control group (CG), a group treated with dimethylhydrazine (DMH), and a group given DMH and inulin, a prebiotic (DMH+PRE). The effects of inulin on the activities of bacterial glycolytic enzymes, short-chain fatty acids, coliform and lactobacilli counts, cytokine levels, and cyclooxygenase-2 (COX-2) and transcription nuclear factor kappa beta (NFκB) immunoreactivity were measured. Inulin significantly decreased coliform counts (p < 0.01), increased lactobacilli counts (p < 0.001), and decreased the activity of β-glucuronidase (p < 0.01). Butyric and propionic concentrations were decreased in the DMH group. Inulin increased its concentration that had been reduced by DMH. Inulin decreased the numbers of COX-2- and NFκB-positive cells in the tunica mucosae and tela submucosae of the colon. The expression of IL-2, TNFα, and IL-10 was also diminished. This 28-week study showed that dietary intake of inulin prevents preneoplastic changes and inflammation that promote colon cancer development.

무용인구의 저변 확대를 위한 방안

경임순 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

Art has it's value based on the expression of the actual life, and the purity of art that is expressed and developed by the specific expert evokes common people's consensus and then has the popularity. But, the popularity of dancing art is getting weakened and the number of dancing population is getting reduced unlike the other arts. Therefore, I herewith describe the solution or alternative for enlarging the dancing population based on the appreciation that enlarging the dancing population shall be achieved when common people understand or accept the image dancer try to express and also, I consider how dancing society tries to solve the problem. We should perform the dancing corresponding to common people's feeling without losing artistic feeling in order to let the art be with common people as the part of their lifes and to enlarge the dancing population, and I herewith state some of alternatives. Fist of all, I look for the solution allowing the common people to better understand the dancing performance and ask for technical solution for achieving the popularity through the variety of trials for creative dancing. And also, I herewith suggest to utilize the little theaters in terms of investment for and growing the dancing population with exceeding the existing passive method, to achieve the popularity through the performance of excellent and marketable works and to grow the planner specialized in the dancing as some of alternatives. Finally, I suggest to activate the dancing culture of the community with local government agencies. It is true that dancing art is not easy to share among the common people living at the specialized modern society, but the dancing should not be reserved for only specialized dancer as the dancing art without any popularity shall be alienated without being considered. This consciousness of crisis is the most fundamental and important assertion stated in this paper.

Effect of Selenium on Lipid Alternations in Pigment-forming Yeasts

Milan Čertík,Emília Breierová,Monika Oláhová,Ján Šajbidor,Ivana Márová 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.suppl1

The work deals with lipid modifications of pigment-forming yeasts Rhodotorula and Sporobolomyces growing under presence of selenium. This metal in the medium significantly prolonged lag-phase of all cultures and enlarged yeast cells. Total, neutral, and membrane yeast lipids (phosphatidylcholine, phosphatidylethanolamine,phosphatidylserine, and phosphatidylinositol) consisted of predominantly palmitic, palmitoleic, stearic, oleic, linoleic,and linolenic acids. Selenium activated fatty acid unsaturation mainly in phosphatidylcholine due to elevated levels of linoleic and linolenic acids. Because biosynthesis of C18unsaturated fatty acids in Rhodotorula and Sporobolomyces species may be associated with phosphatidylcholine moieties,selenium might be involved to the induction of membranebound fatty acid Δ12 and Δ15 desaturases in red yeasts. Oppositely, neutral lipids (primarily triacylglycerols) did not show such intensive changes in fatty acid composition as their polar counterparts. These observations could be applied for preparation of selenized red yeasts containing carotenoid pigments with enhanced accumulation of linoleic and linolenic acids.

A study about determination of preliminary design & minimum reinforcement ratios

Varol KOC,Yusuf EMİROGLU 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.17 No.5

In the standards, minimum reinforcement ratios are presented as the least reinforcement ratios that bearing elements should have in a way to include all systems and in general. However, naturally these general minimum ratios might be presented as being lower than the normally required reinforcement ratios by criteria such as system size, bearing system arrangement, section situation and distributions of the elements and earthquake effect. In this case, minimum reinforcement ratios may remain as meaningless restrictions. Then grouping the criterion that might affect reinforcement ratios according to certain parameters and creating minimum reinforcement ratios regarding preliminary design will provide ease and safety during the project designing. Moreover, it will enable fast and simple examinations in the beginning of project control and evaluation process. By means of the data which could be defined as “preliminary design & minimum reinforcement ratios”, a more realistic and safe restriction compared to general minimum reinforcement ratios could be presented. As a result of numerous comprehensive studies, reinforcement ratios to include all certain systems might be obtained. Today, thanks to the development level of finite elements programs which can make reinforced concrete modelling, with the studies that are impossible to carry out beforehand, this deficiency in the minimum reinforcement ratios in the standarts may at least be partially made up with the advisory regulation of preliminary design & minimum reinforcement ratios. As the structure of the system to be examined and the diversity of the parameters range from the specific to the general, preliminary design & minimum reinforcement ratios will approximate to general minimum reinforcement ratios in real terms. By focusing on a more specific system structure and diversity of the parameters, preliminary design and even design reinforcement ratios will be approximated. In this preliminary study, a route between these two extremes was attempted to be followed. Today, it is possible to determine suggested practical ratios for project designs through carrying out numerous studies.

Application of carbon nanotube coated aluminosilicate beads as “support on support” catalyst for hydrogenation of nitrobenzene

László Vanyorek,Ádám Prekob,EmÅke Sikora,Edina Reizer,Gábor Muránszky,Ferenc Kristály,Béla Viskolcz,Béla Fiser 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-

Nitrogen-doped bamboo-like carbon nanotube (N-BCNT) coating was synthesized onto the surface ofzeolite beads by using Catalytic Chemical Vapour Deposition (CCVD) method to develop a “support onsupport” (SoS) system. These complex structured materials were used as supports during the preparationof hydrogenation catalysts. Rhodium, palladium and platinum nanoparticles were depositedhomogeneously onto the surface of the N-BCNTs of the SoS (final metal content 2 wt%). The catalyticactivity of these samples was compared in the hydrogenation of nitrobenzene. The Pt/N-BCNT-zeolitesample was the most active (182 mol nitrobenzene after 30 min). The activity of the other two catalysts at20 bar was well below this value, 99.5 mol after 60 min and 96 mol after 120 min for Pd and Rh,respectively. The aniline selectivity was different for the three catalysts and they facilitate the formationof various by-products (e.g. N-methylaniline, cyclohexylamine). The usage of the Pd and Pt/NBCNT-zeolite catalysts are more convenient, as only one main by-product was formed. It was confirmedthat the zeolite supported N-BCNTs are efficient catalyst supports in hydrogenation processes. Furthermore, by using this special SoS structure to support the catalytic metals the applicability iswidened and the catalyst removal is easier.

THE COMPLEMENTARY EFFECT OF EXPORT MARKET ORIENTATION AND ENTREPRENEURIAL ORIENTATION ON THE INTERNATIONAL PERFORMANCE OF SMEs

Florin Sabin Foltean,Emöke-Szidonia Feder 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.11

This research explore the complementarity effect of export-market orientation and entrepreneurial orientation on export performance of SMEs from a CEE developing economy. We found that the likelihood of this effect on export profitability is higher in dynamic export market environments if high level of resources are committed to export operations.

The novel continuous bilateral parascapular sub-iliocostalis plane block for thoracic spinal surgery

Almeida Carlos Rodrigues,Vieira Lígia S.,Francisco Emília M.,Antunes Pedro F. 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.2

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주의력결핍/과잉운동장애에서 전두엽과 미상핵의 뇌자기공명영상상 연구

공석원,이정섭,류인균,홍강의 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

목 적 : 미상핵은 전두엽의 각 부분으로부터 입력신호를 받고 있어서 주의력겹핍/과잉운동장애의 원인을 연구하는 분야에서 주목을 받고 있다. 본 연구에서는 주의력결핍/과잉운동장애에서 전두엽과 미상핵의 정상적 비대칭성이 어떻게 관찰되는지를 뇌자기공명영상을 통하여 알아보려고 하였다. 방법 : DSM-III-R의 진단 기준에 맞는 14명의 주의력결핍/과잉운동장애 남아(평균11.1, 표준편차 3.0)와 16명의 두통 대조군(평균연령 10.6, 표준편차 2.5)에서 뇌자기공명영상상을 후향적으로 모집하였다. 분석을 위해서는 미상핵이 가장 잘보이는 축영상중 한 단면을 선택하였다. 뇌자기공명영상은 평판형 스캐너로 읽어들여서 Brainimage Pascal 2.3.3.1 프로그램을 이용해서 분석하였다. 화소수 및 면적을 측정하였으며, 검사자간 신뢰도는 0.89 이상이었다. 결과 : 환자군과 대조군 모두에게 우측 전두엽과 우측 미상핵의 면적이 컸다. 그리고, 이 차이는 대조군에만 통계적으로 유의하였다. 전두엽과 미상핵이 정상적인 비대칭성이 주의력결핍/과잉운동장애 환아군에서는 관찰되지 않았다. 결론 : 우측전두엽발달과정의 문제가 주의력 결핍/과잉행동장애의 원인이라는 가설을 지지하는 증거라고 할 수 있을 것이다. Objectives Because the caudate nucleus receives inputs from the dorsolateral prefrontal and orbitofrontal cortices, it is the area of the interest with ADHD patients in many researches. To identify the lack of normal asymmetry in the frontal lobe and caudate nucleus of the subjects with ADHD, one slice of brain MR images for each subjects were selected, and planimetric method was applied and analyzed. Methods : The brain MR images of 14 ADHD boys who met the DSM-111-R diagnostic criteria and 16 headache control group were collected. Single best view for the head of the caudate nucleus, one axial slice was selected for analysis. MR images were redigitized with flatbed scanner and data were analyzed with Brainimage Pascal 2.3.3.1 software. Pixel counting and area measurements were done. Interrater reliabilities were 0.89 or greater. Results : In both ADHD and control groups, right caudate area was slightly greater than left side, and this difference were more significant in control group. The results showed that the normal asymmetry of frontal lobe and the caudate nucleus was not observed far the ADHD group. Conclusion : The normal asymmetry of the frontal lobe and the caudate nucleus was not seen in boys with ADHD.

Effect of ultrasonic tip designs on intraradicular post removal

Anny Carine Barros Aguiar,Daniely Amorim de Meireles,André Augusto Franco Marques,Emílio Carlos Sponchiado Júnior,Angela Delfina Bitencourt Garrido,Lucas da Fonseca Roberti Garcia 대한치과보존학회 2014 Restorative Dentistry & Endodontics Vol.39 No.4

Objectives: To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. Materials and Methods: The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip. Ultrasonic vibration was applied for 15 seconds on each post surface and tensile test was performed in a Universal Testing Machine (Instron 4444 - 1 mm/min). Results: G4 presented the highest mean values, however, with no statistically significant difference in comparison to G3 (p > 0.05). G2 presented the lowest mean values with statistically significant difference to G3 and G4 (p < 0.05). Conclusions: Ultrasonic vibration with elongated cylindrical-shaped and active rounded tip was most effective in reducing force required for intraradicular post removal.

Isolation, in vitro propagation, genetic analysis, and immunogenic characterization of an Ehrlichia canis strain from southeastern Brazil

Rosiane Nascimento Alves,Susana Elisa Rieck,Carlos Ueira-Vieira,Marcelo Bahia Labruna,Marcelo Emílio Beletti 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2

Amplification of the 16S rRNA gene from a blood sampleobtained from a dog in southeastern Brazil was used to confirma naturally acquired Ehrlichia (E.) canis infection. Followingisolation and culturing of the new bacterial strain calledUberlândia, partial sequences of the dsb and p28 genes wereobtained. The dsb partial sequence of the novel strain was100% similar to dsb gene sequences of E. canis obtained fromdifferent geographic areas around the world. Conversely, thep28 partial sequence for the E. canis Uberlândia strain differedat several nucleotides from other sequences available inGenBank. To confirm the antigenic profile of the Uberlândiastrain, an indirect immunofluorescence assay against E. canisantigens was performed using dog sera collected from twodifferent areas in Brazil (Uberlândia and São Paulo). Theresults suggest that both antigens were able to identify animalsseropositive for E. canis in Brazil since these Brazilian strainsappear to be highly conserved.