Improvement of「RCM」for Decision Making on Maintenance Task of Weapon Systems

Eo,Seong Phil,Chung,IL Han,Kim,Dae Yong 韓國防衛産業學會 2008 韓國防衛産業學會誌 Vol.15 No.2

RCM은 최저의 비용으로 장비의 운용효과를 향상시킬 수 있는 예방정비계획을 수립하는 이론으로서 국내에는 대형 설비 및 운송체계 뿐만 아니라 무기체계에서도 이를 적용하고 있다. 하지만 국내 무기체계 개발/운용 과정에서 RCM 활동은 여러 가지 제약사항으로 인해 적극적으로 진행되지 못하고 있으며, 이로 인해 현재 정비업무의 적합성을 정기적으로 검토하지 못하고 정비업무 최적화를 이루지 못하고 있는 실정이다.따라서 본 연구에서는 이러한 정비업무 수립문제의 해소방안을 알아보고자 기존 정비업무 선정활동, RCM 적용 실태 및 개선점을 알아보고 더 나아가 전통적인 RCM 결정논리의 발전방향을 살펴보았다.

Spectal Characteristics of Dry-Vegetation Cover Types Observed by Hyperspectral Data

Lee Kyu-Sung,Kim Sun-Hwa,Ma Jeong-Rim,Kook Min-Jung,Shin Jung-Il,Eo Yang-Dam,Lee Yong-Woong The Korean Society of Remote Sensing 2006 大韓遠隔探査學會誌 Vol.22 No.3

Because of the phenological variation of vegetation growth in temperate region, it is often difficult to accurately assess the surface conditions of agricultural croplands, grasslands, and disturbed forests by multi-spectral remote sensor data. In particular, the spectral similarity between soil and dry vegetation has been a primary problem to correctly appraise the surface conditions during the non-growing seasons in temperature region. This study analyzes the spectral characteristics of the mixture of dry vegetation and soil. The reflectance spectra were obtained from laboratory spectroradiometer measurement (GER-2600) and from EO-1 Hyperion image data. The reflectance spectra of several samples having different level of dry vegetation fractions show similar pattern from both lab measurement and hyperspectral image. Red-edge near 700nm and shortwave IR near 2,200nm are more sensitive to the fraction of dry vegetation. The use of hyperspectral data would allow us for better separation between bare soils and other surfaces covered by dry vegetation during the leaf-off season.

Spectal Characteristics of Dry-Vegetation Cover Types Observed by Hyperspectral Data

Kyu Sung Lee,Sun Hwa Kim,Jeong Rim Ma,Min Jung Kook,Jung II Shin,Yang Dam Eo,Yong Woong Lee 大韓遠隔探査學會 2006 大韓遠隔探査學會誌 Vol.22 No.3

Because of the phenological variation of vegetation growth in temperate region, it is often difficult to accurately assess the surface conditions of agricultural croplands, grasslands, and disturbed forests by multi-spectral remote sensor data. In particular, the spectral similarity between soil and dry vegetation has been a primary problem to correctly appraise the surface conditions during the non-growing seasons in temperature region. This study analyzes the spectral characteristics of the mixture of dry vegetation and soil. The reflectance spectra were obtained from laboratory spectroradiometer measurement (GER-2600) and from EO-1 Hyperion image data. The reflectance spectra of several samples having different level of dry vegetation fractions show similar pattern from both lab measurement and hyperspectral image. Red-edge near 700nm and shortwave IR near 2,200nm are more sensitive to the fraction of dry vegetation. The use of hyperspectral data would allow us for better separation between bare soils and other surfaces covered by dry vegetation during the leaf-off season.

P167 : Validity and reliability of a new in-vivo method for efficacy testing of skin cleansers using a digital image analysis of cyanoacrylate skin surface stripping

( Eo Gin Lee ),( Dong Joo Hyun ),( Jae Yang Park ),( Kyu Young Seo ),( Sang Eun Lee ),( Hee Jung Lee ),( Moon Soo Yoon ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Presently, only few tests have been published for evaluating the efficacy of skin cleansers, and they are neither standardized nor widely-accepted. Objectives: We developed a new in-vivo test method for the semi-quantitative evaluation of the efficacy of cleansing products and evaluated its validity and reliability. Methods: Five different skin cleansers were tested on the forearms of 25 healthy volunteers according to the washing procedure using standard dirt. We evaluated the residual amount of standard dirt on the cyanoacrylate skin surface stripping sample using a dermoscopy and an image analysis program. We also graded the cleansing power through a pattern analysis of dermoscopic images. For the comparison regarding the validity, we obtained data according to other preexisting methods using a Chromameter, Mexameter and Glossymeter. Results: The cleansing efficacy of five skin cleansers which was assessed by our new method showed significant correlations with the results from other preexisting methods using a Chromameter and Mexameter (Pearson correlation coefficient 0.826 and 0.738, respectively, P<0.001). This new method also showed a high internal consistency reliability (Cronbach`s alpha=0.997). Conclusion: We presented a new in-vivo method for assessing the cleansing efficacy of skin cleansers which was shown to be reliable and valid. Further studies are required to establish a standardized method to objectify cleansing effectiveness of skin cleansers.

Tree-Structured Mixed-Effects Regression Modeling for Longitudinal Data

Eo, S.-H.,Cho, H. AMERICAN STATISTICAL ASSOCIATION 2014 Journal of computational and graphical statistics Vol.23 No.2

Resveratrol regulates type II collagen and COX-2 expression via the ERK, p38 and Akt signaling pathways in rabbit articular chondrocytes

EO, SEONG-HUI,CHO, HONG-SIK,KIM, SONG-JA D.A. Spandidos 2014 Experimental and therapeutic medicine Vol.7 No.3

<P>Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resveratrol in normal cells, including chondrocytes, have not yet been clearly elucidated. The aim of the present study was to evaluate the effects of resveratrol on differentiation and inflammation in rabbit articular chondrocytes and to investigate the underlying mechanism of action. Rabbit articular chondrocytes were treated with 20 μM resveratrol for different time periods or with various concentrations of resveratrol for 24 h. It was observed that the expression levels of type II collagen and sulfated proteoglycan, as determined by western blot analysis and Alcian blue staining, respectively, increased following treatment with resveratrol in a concentration-dependent manner at concentrations up to 20 μM and then decreased at higher concentrations. The expression levels of cyclooxygenase (COX-2) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) began to increase at 10 min after the addition of resveratrol, reached peak levels at 3 h and decreased from the peak level thereafter, as determined by western blot analysis and PGE<SUB>2</SUB> assay, respectively. It was also demonstrated that resveratrol caused phosphorylation of mitogen-activated protein kinase proteins [extracellular signal-regulated kinases (ERK), p38 and c-Jun N-terminal kinases (JNK)] and Akt in rabbit articular chondrocytes. The inhibition of ERK, p38 kinase, phosphoinositide 3-kinase (PI3K) and Akt with PD98059, SB203580, LY294002 and triciribine, respectively, suppressed resveratrol-induced type II collagen and COX-2 expression. However, inhibition of JNK with SP600125 produced no clear changes in the expression levels of type II collagen and COX-2. The results suggest that resveratrol in articular chondrocytes stimulates differentiation and inflammation via the ERK, p38 and Akt signaling pathways.</P>

P160 : The efficacy and safety of combined microneedle fractional radiofrequency and sublative fractional radiofrequency for acne scars in Asian skin

( Eo Gin Lee ),( Dong Joo Hyun ),( Jae Yang Park ),( Kyu Young Seo ),( Sang Eun Lee ),( Hee Jung Lee ),( Moon Soo Yoon ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Microneedle fractional radiofrequency (RF) induces deep dermal heating and leaves the epidermis less affected, which showed therapeutic effects for wrinkle, pore and various scars. Sublative fractional RF induces not only superficial fractional ablation of upper epidermis but also upper dermal remodeling, which had been reported to show improvement of skin aging. Objectives: We evaluated efficacy and safety of combined microneedle fractional RF and sublative fractional RF for acne scars in Asian skin. Methods: 20 patients (mean age 23.65±2.94, skin phototype III-IV) received three consecutive combined microneedle fractional RF and sublative fractional RF at 4-week intervals over 12 weeks. Investigator`s global assessment and complications were assessed up to 2 months after last treatment by standardized photographs. Subjective improvement and pain score were also assessed. Results: Follow-up results revealed that 4 patients had clinical improvement of 76% to 100%, 10 had improvements of 51% to 75%, 6 had improvements of 26% to 50%. The mean duration of post-therapy crusting or scaling was 5.21 days and post-therapy erythema lasted 2.52 days. Conclusion: We suggest that combined microneedle fractional RF and sublative fractional RF may provide a new treatment algorithm for acne scars in Asians. The limitations are the small number of patients.

Anti-inflammatory effects of 18-nor-ent-pimara-9(11),15-diene-4β-ol isolated from the roots of Aralia continentalis on LPS-induced in RAW264.7 cells

Eo Hyun Ji,Park Youngki,Hong Seong Su,Park Gwang Hun 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.6

Aralia continentalis (A. continentalis) is a medicinal plant belonging to Araliaceae, it has been reported to exert anticancer, anti-bacterial, anti-inflammatory, anti-platelet and anti-oxidative activities. But the potential mechanism for the anti-inflammatory effect of compounds isolated from the roots of A. continentalis is still insufficient. So, we evaluated whether compounds isolated from the roots of A. continentalis exert anti-inflammatory effects and elucidated its potential mechanism in RAW264.7 cells. The concentrated residue was subsequently suspended in H2O and partitioned with n-hexane, methylene chloride ( CH2Cl2), ethyl acetate (EtOAc) and n-butanol (n-BuOH). The fractions were subjected to sequential column chromatography over silica-gel, RP-18, MPLC, recycling and preparative HPLC to isolated the novel compound. The novel compound was identified as 18-nor-ent-pimara-9(11),15-diene-4β-ol and confirmed anti-inflammatory activity. The 18-nor-ent-pimara-9(11),15-diene-4β-ol dose-dependently blocked NO production and inhibited iNOS, COX-2, TNF-α and IL-1β expression in LPS-stimulated RAW264.7 cells. The 18-nor-entpimara- 9(11),15-diene-4β-ol inhibited LPS-stimulated degradation of IκB-α and nuclear accumulation of p65, which resulted in the suppression of NF-κB activation in RAW264.7 cells. Also, the 18-nor-ent-pimara-9(11),15-diene-4β-ol attenuated the phosphorylation of p38 and ERK1/2 in LPS-induced RAW264.7 cells. These results suggest that the norent- pimara-9(11),15-diene-4β-ol isolated from the roots of A. continentalis may have grate potential for the development of anti-inflammatory drugs.

Brown Alga <i>Ecklonia cava</i> Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice

Eo, Hyeyoon,Jeon, You-jin,Lee, Myoungsook,Lim, Yunsook American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.1

<P>Obesity is considered to be a metaflammatory condition. <I>Ecklonia cava</I>, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. This study investigated the effect of <I>E. cava</I> polyphenol extract (ECPE) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. After obesity was induced by a high-fat diet (HFD), the mice were administered ECPE by gavage for 5 days/12 weeks. ECPE supplementation reduced body weight gain, adipose tissue mass, plasma lipid profiles, hepatic fat deposition, insulin resistance, and the plasma leptin/adiponectin ratio derived from HFD-induced obesity. Moreover, ECPE supplementation selectively ameliorated hepatic protein levels associated with lipogenesis, inflammation, and the antioxidant defense system as well as activation of AMPK and SIRT1. Collectively, ECPE supplement might have potential antiobesity effects via regulation of AMPK and SIRT1 in HFD-induced obesity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-1/jf502830b/production/images/medium/jf-2014-02830b_0008.gif'></P>

A 1V 200kS/s 10-bit Successive Approximation ADC for a Sensor Interface

EO, Ji-Hun,KIM, Sang-Hun,JANG, Young-Chan The Institute of Electronics, Information and Comm 2011 IEICE transactions on electronics Vol. No.

<P>A 200kS/s 10-bit successive approximation (SA) analog-to-digital converter (ADC) with a rail-to-rail input signal is proposed for acquiring biosignals such as EEG and MEG signals. A split-capacitor-based digital-to-analog converter (SC-DAC) is used to reduce the power consumption and chip area. The SC-DAC's linearity is improved by using dummy capacitors and a small bootstrapped analog switch with a constant on-resistance, without increasing its area. A time-domain comparator with a replica circuit for clock feed-through noise compensation is designed by using a highly differential digital architecture involving a small area. Its area is about 50% less than that of a conventional time-domain comparator. The proposed SA ADC is implemented by using a 0.18-µm 1-poly 6-metal CMOS process with a 1V supply. The measured DNL and INL are +0.44/-0.4 LSB and +0.71/-0.62 LSB, respectively. The SNDR is 55.43dB for a 99.01kHz analog input signal at a sampling rate of 200kS/s. The power consumption and core area are 5µW and 0.126mm<SUP>2</SUP>, respectively. The FoM is 47fJ/conversion-step.</P>