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RISS 인기검색어
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- 저자 : Dragana Mitić-Ćulafić (검색결과 2 건)
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Jovana S. Vuković,Aleksandra A. Perić-Grujić,Dragana S. Mitić-Ćulafić,Biljana Dj. Božić Nedeljković,Simonida Lj. Tomić 한국고분자학회 2020 Macromolecular Research Vol.28 No.4
Since the management of infections becomes prior global healthcare issue, the “post antibiotic era” requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 °C. Results confirmed the expected structure, while the glass transition temperatures (Tg) of the hydrogels were detected in range of 10-37 °C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.
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Characterization of Some Potentially Probiotic Lactobacillus Strains of Human Origin
Jelena Novaković Jovanović,Biljana Nikolić,Svetlana Šeatović,Gordana Zavišić,Dragana Mitić-Ćulafić,Branka Vuković-Gačić,Jelena Knežević-Vukčević 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5
A novel preparation for human use was investigated for probiotic properties of new lactobacilli isolates from oral and fecal samples of children. Identified strains were Lactobacillus plantarum (Lac1, Lac2, Lac6, and Lac7), Lactobacillus casei (Lac3), and Lactobacillus paracasei (Lac4). Isolates were non-hemolytic, produced organic acids, were tolerant to wide ranges of temperature, NaCl, and pH, and were highly resistant to lysozyme, acidity, and bile salts. High survival rates in artificial gastric and intestinal fluids indicated abilities to survive passage through the gastrointestinal tract. Antimicrobial activities were restricted to bacteria, attributed to low pH values. Isolated strains possessed good aggregation abilities, high hydrophobicity values, and moderate abilities to adhere to HCT 116 cells. Substantial probiotic features were identified for all isolates. Lac2, Lac6, and Lac7 were identified as the most advantageous candidates for further study of other probiotic and technological properties.
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