http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Dorry Boll (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Lara Burg,Maite Timmermans,Maaike van der Aa,Dorry Boll,Koen Rovers,Ignace de Hingh,Anne van Altena 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5
Objective: Peritoneal metastases (PM) are a challenge in gynecological cancers, but itsappearance has never been described in a population-based study. Therefore, we describe theincidence of PM and identify predictors that increase the probability of peritoneal spread. Methods: All ovarian, endometrial and cervical cancer patients diagnosed in the Netherlandsbetween 1989 and 2015 were identified from the Netherlands Cancer Registry and stratifiedfor PM. Crude and age-adjusted incidence over time was calculated. Independent predictorsfor PM were identified using uni- and multivariable analyses. Results: The 94,981 patients were diagnosed with ovarian, endometrial or cervicalcancer and respectively 61%, 2% and 1% presented with PM. Predictors for PM in ovariancancer were: age between 50 and 74 years (odds ratio [OR]=1.19; 95% confidence interval[CI]=1.08–1.32), other distant metastases (OR=1.25; 95% CI=1.10–1.41), poor differentiationgrade (OR=2.00; 95% CI=1.73–2.32) and serous histology. Predictors in endometrial cancerwere lymph node metastases (OR=2.32; 95% CI=1.65–3.26), other distant metastases(OR=1.38; 95% CI=1.08–1.77), high-grade tumors (OR=1.95; 95% CI=1.38–2.76) and clearcell (OR=1.49; 95% CI=1.04–2.13) or serous histology (OR=2.71; 95% CI=2.15–3.42). Incervical cancer, the risk is higher in adenocarcinoma than in squamous cell carcinoma(OR=4.92; 95% CI=3.11–7.79). Conclusion: PM are frequently seen in patients with ovarian cancer. In endometrial andcervical cancer PM are rare. Histological subtype was the strongest predictive factor for PMin all 3 cancers. Better understanding of predictive factors for PM and thus the biologicalbehavior is of paramount importance.
-
Casper Reijnen,Nicole CM Visser,Jenneke C Kasius,Dorry Boll,Peggy M Geomini,Huy Ngo,Dennis van Hamont,Brenda M Pijlman,Maria Caroline Vos,Johan Bulten,Marc PLM Snijders,Leon FAG Massuger,Johanna MA Pi 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.5
Objectives The global obesity epidemic has great impact on the prevalence of low-grade endometrial carcinoma. The preoperative tumor serum marker cancer antigen 125 (CA-125) might contribute to improved identification of high-risk patients within this group. The study aimed to investigate the prognostic value of CA-125 in relation to established preoperative prognosticators, with a focus on identifying patients with poor outcome in low-grade endometrial carcinoma (EC) patients. Methods Prospective multicenter cohort study including all consecutive patients surgically treated for endometrial carcinoma in nine collaborating hospitals from September 2011 until December 2013. All preoperative histopathological diagnoses were reviewed in a blinded manner. Associations between CA-125 and clinicopathological features were determined. Univariable and multivariable analysis by Cox regression were used. Separate analyses were performed for preoperatively designated low-grade and high-grade endometrial carcinoma patients. Results A total of 333 patients were analyzed. CA-125 was associated with poor prognostic features including advanced International Federation of Gynecology and Obstetrics (FIGO) stage. In multivariable analysis, age, preoperative tumor and CA-125 were significantly associated with disease-free survival (DFS); preoperative grade, tumor type, FIGO and CA-125 were significantly associated with disease-specific survival (DSS). Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125. Conclusion Preoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS. Particularly patients with low-grade EC and elevated CA-125 represent a group with poor outcome and should be considered as high-risk endometrial carcinoma.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
