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Fabrication and Characterization of an OTFT-Based Biosensor Using a Biotinylated F8T2 Polymer
Sang Chul Lim,양용석,Seong Hyun Kim,Zin-Sig Kim,Doo-Hyeb Youn,Taehyoung Zyung,Ji Young Kwon,황도훈,김도진 한국전자통신연구원 2009 ETRI Journal Vol.31 No.6
Solution-processable organic semiconductors have been investigated not only for flexible and large-area electronics but also in the field of biotechnology. In this paper, we report the design and fabrication of biosensors based on completely organic thin-film transistors (OTFTs). The active material of the OTFTs is poly(9,9-dioctylfluorene-co-bithiophene) (F8T2) polymer functionalized with biotin hydrazide. The relationship between the chemoresistive change and the binding of avidin-biotin moieties in the polymer is observed in the output and on/off characteristics of the OTFTs. The exposure of the OTFTs to avidin causes a lowering of ID at VD = -40 V and VG = -40 V of nearly five orders of magnitude.
O-Chlorobenzylidene Malononitrile (CS)이 폐포간중격 제 2 형 폐포세포의 미세구조에 미치는 영향
정호삼,김병익,백두진,Chung, Ho-Sam,Kim, Byung-Ik,Paik, Doo-Zin 한국현미경학회 1994 Applied microscopy Vol.24 No.1
In order to investigating the pulmonary toxicity of the O-chlorobenzyledene malononitrile (CS), lacrimating agent, $2.6g/m^3$ of CS was inhalated to Sprague-Dawley rats in the plastic chamber for 20 minutes. The ultrastructural changes of type II pneumocytes in the lung were observed with Hitachi 600 transmission electron microscope. The results obtained were as follows: 1. 3 hours after exposure to CS the fusion of surface microvilli, dilatation of cristernae of the rough endoplasmic reticulum, atrophy of Golgi complex and condensation, deletion of lamellated membranes in lamellar bodies were observed in type II pneumocytes. 2. One and 2 days after CS-exposure, disorganization of mitochondrial double membranes, fragmentations of rough endoplasmic reticulum were found in the great alveolar cells. In addition, decrease in amount of polyribosome granules and deletion or condensation of lamellated membranes in lamellar bodies were also observed. 3. 4 days after exposure to CS, the type II pneumocyte revealed new whorled lamellar membranes in lamellar bodies, a few intact rough endoplasmic reticulum and restoration of polyribosome granules. It is consequently suggested that CS induces degenerative changes of cytoplasmic organelles in the type II pneumocytes.