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SURF4 has oncogenic potential in NIH3T3 cells
Kim, Jayoung,Hong, Chae Mi,Park, Su Min,Shin, Dong Hoon,Kim, Jee Yeon,Kwon, Sang-Mo,Kim, Jae Ho,Kim, Chi Dae,Lim, Dae-Sik,Lee, Dongjun Elsevier 2018 Biochemical and biophysical research communication Vol.502 No.1
<P><B>Abstract</B></P> <P>SURF4, which is located in the Surfeit gene cluster, encodes for a conserved integral membrane protein containing multiple putative transmembrane regions. However, the physiological role of SURF4 has not been determined. We found that <I>SURF4</I> demonstrated aberrant amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 led to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in the mice. Collectively, our findings demonstrate that SURF4 has the potential for inducing cellular transformation and cell migration <I>in vitro</I> and has oncogenic transformation ability <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>SURF4</I> was found to be amplified and highly expressed in the tumor tissues of several human cancer patients. </LI> <LI> Patients with tumors exhibiting high <I>SURF4</I> expression had significantly shorter overall survival than low <I>SURF4</I> expression. </LI> <LI> <I>SURF4</I> can induce cellular transformation and cell migration <I>in vitro</I> and promotes oncogenic transformation <I>in vivo.</I> </LI> </UL> </P>
RhoA is associated with invasion and poor prognosis in colorectal cancer
JEONG, DONGJUN,PARK, SOYOUNG,KIM, HYUNGJOO,KIM, CHANG-JIN,AHN, TAE SUNG,BAE, SANG BYUNG,KIM, HAN JO,KIM, TAE HYUN,IM, JUNGKYUN,LEE, MOON SOO,KWON, HYOG YOUNG,BAEK, MOO JUN Spandidos Publications 2016 International journal of oncology Vol.48 No.2
<P>Colorectal cancer is one of the most common cancers and is the fourth leading cause of cancer death in Korea. Mortality of colorectal cancer is strongly associated with the metastatic spread of the disease. As such, it is important to find and characterize signaling pathways involved in colon cancer metastasis. We investigated the functional importance of RhoA using human cell lines as well as 150 colorectal cancer patient-derived samples as it remains unclear whether RhoA functions as either an oncogene or a tumor suppressor in colon cancer. RhoA was highly expressed in metastatic cancer cell lines. Although cancer cell proliferation was only moderately impaired after depletion of RhoA, RhoA-depleted cancer cells exhibited markedly reduced migration and invasion ability in vitro. Furthermore, we found that RhoA is associated with the invasion of lymph nodes and blood vessels in the patient colorectal cancer samples. Most notably, patients with higher RhoA expression had a significantly poorer 5-year survival rate after surgery. These results suggest that RhoA is a marker of poor prognosis in colorectal cancer and may be a promising target for cancer treatment.</P>
서울시 구로구에서 COVID-19 발생 전ㆍ후 초미세먼지(PM2.5) 농도 변화에 따른 인구집단 노출평가
김동준(Dongjun Kim),민기홍(Gihong Min),최영태(Yongtae Choe),신준섭(Junshup Shin),우재민(Jaemin Woo),김동준(Dongjun Kim),신정현(Junghyun Shin),조만수(Mansu Jo),성경화(Kyeonghwa Sung),최윤형(Yoon-hyeong Choi),이채관(Chaekwan Lee),최길용(K 한국환경보건학회 2021 한국환경보건학회지 Vol.47 No.6
Background: The coronavirus disease (COVID-19) has caused changes in human activity, and these changes may possibly increase or decrease exposure to fine dust (PM2.5). Therefore, it is necessary to evaluate the exposure to PM2.5 in relation to the outbreak of COVID-19. Objectives: The purpose of this study was to compare and evaluate the exposure to PM2.5 concentrations by the variation of dynamic populations before and after the outbreak of COVID-19. Methods: This study evaluated exposure to PM2.5 concentrations by changes in the dynamic population distribution in Guro-gu, Seoul, before and after the outbreak of COVID-19 between Jan and Feb, 2020. Gurogu was divided into 2,204 scale standard grids of 100 m×100 m. Hourly PM2.5 concentrations were modeled by the inverse distance weight method using 24 sensor-based air monitoring instruments. Hourly dynamic population distribution was evaluated according to gender and age using mobile phone network data and time-activity patterns. Results: Compared to before, the population exposure to PM2.5 decreased after the outbreak of COVID-19. The concentration of PM2.5 after the outbreak of COVID-19 decreased by about 41% on average. The variation of dynamic population before and after the outbreak of COVID-19 decreased by about 18% on average. Conclusions: Comparing before and after the outbreak of COVID-19, the population exposures to PM2.5 decreased by about 40%. This can be explained to suggest that changes in people’s activity patterns due to the outbreak of COVID-19 resulted in a decrease in exposure to PM2.5.
등온반응기와 단열반응기 조합으로 구성된 0.25 MW급 메탄합성 파일롯 공정 운전특성
김수현(Suhyun Kim),유영돈(Youngdon Yoo),강석환(Sukhwan Kang),류재홍(Jaehong Ryu),김진호(Jinho Kim),김문현(Munhyun Kim),고동준(Dongjun Koh),이현정(Hyunjung Lee),김광준(Gwangjun Kim),김형택(Hyungtaek Kim) 한국청정기술학회 2013 청정기술 Vol.19 No.2
본 연구에서는 등온반응기와 단열반응기로 구성된 0.25 MW 메탄합성 파일롯 공정 실험을 통한 운전 특성을 분석하였다. 등온반응기는 메탄합성 반응을 통해 발생하는 열을 포화수의 유량과 압력을 통해 강제적으로 제어할 수 있는 반응기로 등온반응기와 단열반응기를 조합할 경우 기존 단열반응기만으로 구성된 메탄합성 공정에 비해 반응기 개수를 줄일 수 있다. 또한 합성가스 재순환이 불필요하기 때문에 단열반응기 조합으로 구성된 메탄합성 공정에서 비용의 약 15~20%를 차지하는 재순환 압축기를 제거할 수 있다. 등온반응기로 유입되는 합성가스의 H2/CO 비가 3보다 낮은 경우에는 튜브에 충진된 촉매에 탄소 침적 현상이 일어나 반응기의 차압이 증가하였으며, H₂/CO 비가 3으로 공급되는 경우에는 탄소 침적 현상이 일어나지 않고 메탄합성 반응이 안정적으로 유지되어 CO 전환율 99% 이상, CH₄ 선택도 97% 이상, CH₄ 생산성 최대 695 ml/h·-cat를 얻을 수 있었다. In this study, we analyzed the operational characteristics of a 0.25 MW methanation pilot plant. Isothermal reactor controled the heat released from methanation reaction by saturated water in shell side. Methanation process consisting of isothermal reactor and adiabatic reactor had advantages with no recycle compressor and more less reactors compared with methanation process with only adiabatic reactors. In case that H2/CO ratio of syngas was under 3, carbon deposition occurred on catalyst in tube side of isothermal reactor and the pressure of reactors increased. In case that H₂/CO ratio was maintained around 3, no carbon deposition on catalyst in tube side of isothermal reactor was found by monitoring the differential pressure of reactors and by measuring the differential pressure of several of tubes filled with catalyst before and after operating. It was shown that CO conversion and CH₄ selectivity were over 99, 97%, respectively, and the maximum CH₄ productivity was 695 ml/h·g-cat.
Light-induced electrical switch <i>via</i> photo-responsive nanocomposite film
Lee, Wonsik,Kim, Dongjun,Lim, Joonyoung,Kim, Geonho,Kim, Ikyon,Kim, Songkuk,Kim, Jiwon Elsevier 2018 Sensors and actuators. B Chemical Vol.266 No.-
<P><B>Abstract</B></P> <P>Photo-responsive nanomaterials have attracted a lot of attention since they allow a remote control with a non-invasive stimulus—light. Owing to this property, it has been applied to next-generation electrical devices, which are desired to be flexible and transparent for a wider range of applications. Herein, we developed a flexible, transparent and conductive film which can change its shape <I>via</I> light of specific wavelength to control the electrical conductivity between electrodes. The film is composed of three layers: azobenzene incorporated poly(dimethylsiloxane), AzoPDMS; silk fibroin; and silver nanowires, AgNWs. When azobenzene within the polymer changes its molecular arrangement upon irradiation, the difference in volume changes of AzoPDMS and silk fibroin layer results in the film to bend. Since a silk fibroin layer folds inward upon irradiation, AgNWs are coated onto the silk fibroin layer to be selectively in contact with the electrodes. This photo-responsive nanocomposite film is flexible, transparent and conductive which can be connected to the circuit on demand <I>via</I> light acting as an electrical switch. We believe it can be combined with various transparent electronic devices to further expand its applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A flexible, transparent and conductive photo-bending film was fabricated. </LI> <LI> The photo-responsive film consists of photo-responsive/support/conductive layers. </LI> <LI> The film could bend up to 90° with switching time of a few seconds upon irradiation. </LI> <LI> The conductivity of film can be optimized by changing the concentration of silver nanowires. </LI> <LI> The film can be connected to the circuit on demand acting as a light-induced electrical switch. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>