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김성용,금동호,이명종 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
Non-medical use of drugs to enhance performance at Olympic Games by athletes has been prohibited by the International Olympic Committee(IOC) since 1968 on medical and ethical grounds. IOC wants to protect athlete from harmful side effect of drugs due to misuse of it. It also, ethically, wants to have Games run on fair base, not fortified by performance enhancing drugs. The banned substance include stimulants, narcotic analgesics, anabolic, steroids, β-blockers and diuretics. In order to prevent the positive reaction in the doping test induced by herb medicine, this study was done on about Bojungchisheup-tang. The laboratory set up doping analyses methods to cover as many drugs as possible without sacrificing sensitivity and specificity within one procedure. Its screening method considered of four different procedures. The results were negative. According to the above results, Bojungchisheup-tang taken by athletes would show the negative reaction in the doping test. So its prescription for athletes can be given without worries of the doping test.
Maternal Stress Affects Fetal Development and Learning and Memory in Adult Offspring
Dong Ho Geum,Chang Joong Lee,김경진 Kyung Jin Kim 서울대학교 인지과학연구소 2000 Journal of Cognitive Science Vol.1 No.1
It has been well known that stress exerts profound influences on physiological and behavioral consequences in later life. It remains, however, unknown whether maternal stress may affect fetal development and brain functions of adult offspring that was born from stressed mother and reared in a normal environment. In the present study, we showed that maternal stress increased fetal abortion rate up to 30%, decreased body weights of fetuses and neonates, and delayed fetal limb and somite development. Adult mice born from stressed mother have reduction in N-methyl-D-aspartate (NMDA) receptor mediated hippocampal long-term potentiation (LTP) induced by tetanic stimulation with high frequency (l00 Hz) or tetraethyl-ammonium (TEA). They also showed impairment in NMDA receptor mediated excitatory post-synaptic current (EPSC) determined by whole cell patch clamp recording. Morris water maze test and passive fear avoidance test indicated that spatial learning and memory and fear avoid response were impaired in maternally stressed adult offspring even when they were grown in a normal environment. These results suggest that maternal stress reprograms the fetal development and leads to irreversible malfunctions of the brain even in adulthood.
The impact factors on 5-year survival rate in patients operated with oral cancer
Dong-Ho Geum,Young-Chea Roh,Sang-Yong Yoon,Hyo-Geon Kim,Jung-Han Lee,Jae-Min Song,Jae-Yeol Lee,Dae-Seok Hwang,Yong-Deok Kim,Sang-Hun Shin,In-Kyo Chung,Uk-Kyu Kim 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.5
Objectives: The purpose of this study is to analyze clinical impact factors on the survival rate, and to acquire basic clinical data for the diagnosis of oral cancer, for a determination of the treatment plan with long-term survival in oral cancer patients. Materials and Methods: Through a retrospective review of the medical records, the factors for long-term survival rate were analyzed. Thirty-seven patients, among patient database with oral cancer treated in the Department of Oral and Maxillofacial Surgery at Pusan National University Hospital within a period from March 1998 to March 2008, were selected within the study criteria and were followed-up for more than 5 years. The analyzed factors were gender, age, drinking, smoking, primary tumor site, type of cancer, TNM stage, recurrence of affected region, and metastasis of cervical lymph node. The 5-year survival rate on the impact factors was calculated statistically using the Kaplan-Meier method. Results: By classification of clinical TNM at the 1st visit, there were 11 (29.7%) cases for stage I, 11 (29.7%) cases for stage II, 3 (8.1%) cases for stage III, and 12 (32.5%) cases for stage IV. The 5-year survival rate of total oral cancer patients after the operation were 75.7%, pathological TNM stage related 5-year survival rate were as follows: stage I 90.0%, stage II 81.8%, stage III 100% and stage IV 45.5%; in which the survival rate difference by each stage was significantly observed. The recurrence of cervical lymph node was the significant impact factor for the survival rate, because only 30.0% the survival rate in recurrent cases existed. During the follow-up, there were 15 (40.5%) patients with confirmed recurrence, and the 5-year survival rate of these patients was decreased as 46.7%. Conclusion: The classification of clinical and pathological TNM stage, local recurrence after surgery, and metastasis of cervical lymph node after surgery were analyzed as the 3 most significant factors.
Molecular typing of Prototheca zopfii isolated from bovine mastitic milk samples in Korea
Ho Sung Park(Ho Sung Park),Su Jeong Kim(Su Jeong Kim),Geum-Chan Jang(Geum-Chan Jang),Bang-Hun Hyun(Bang-Hun Hyun),Suk-Kyung Lim(Suk-Kyung Lim),Dong Chan Moon(Dong Chan Moon) 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
( Dong Chan Moon ),( Byung-yong Kim ),( Hyang-mi Nam ),( Geum-chan Jang ),( Suk-chan Jung ),( Hee-soo Lee ),( Yong-ho Park ),( Suk-kyung Lim ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.4
Methicillin-resistant Staphylococcus aureus (MRSA), the major causative agent of nosocomial infection, has also been reported from non-human sources. A sequence type (ST) 541 MRSA isolate designated K12PJN53 was isolated from a healthy pig in 2012. The genome of K12PJN53 consists of 44 contiguous sequences (contigs), totalling 2,880,108 bases with 32.88% GC content. Among the annotated contigs, 14, 17, and 18 contained genes related to antimicrobial resistance, adherence, and toxin genes, respectively. The genomic distance of strain K12PJN53 was close to the ST398 strains. This is the first report of the draft genome sequence of a novel livestock-associated MRSA ST541 strain.
Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4