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- 저자 : Dong Hoon Yu Zae Young Ryoo(류재웅) (검색결과 2 건)
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Dong Hoon Yu,Zae Young Ryoo(류재웅) 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-
The circling (cir/cir) mouse is one of the murine models for human non-syndromicdeafness DFNB6. The mice have abnormal circling behavior, suggesting a balanced disorder and profound deafness. The causative gene was trans membrane inner ear (tmie) gene of which the mutation is a 40-kilobase genomic deletion including tmie gene itself. In this study, tmie-over expression trasngenic mice were established. Individuals with germline transmission have been mated with circling homozygous mutantmice (cir/cir) in order to produce the transgenic mutant mice (cir/cir-tg) as agenetherapy. After the genotyping, phenotypic analyses were performed so that the insertion of the new gene might compensate for the diseases such as hearingloss, circling behavior, or swimming inability. Some individuals exhibited complete recovery in their behavior and hearing but the others did not show any amelioration in behavioror hearing. Individual mice had very different levels of tmie transgene expression in the cochlea. These results clearly indicate that tmie protein plays an important role when the appropriate expression level of tmie was expressed in the innerear. The protein levels were variable in each individual and these are thought to induce the differences in disease amelioration levels.
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Dong Hoon Yu,이준규,Hyung Soo Yuh,Seo Jin Park,Hei Jung Kim,Ki Beom Bae,Young Rae Ji,Na Ri Kim,박시준,Do Hyung Kim,김성현,Myoung Ok Kim,이정웅,Zae Young Ryoo,류재웅 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.9
Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase (EC-SOD) and inflammatory arthritis have been shown in several animal odels of RA. However, there is a question whether the over-expression of EC-SOD on arthritic joint also could suppress the progression of disease or not. In the present study, the effect on the synovial tissue of experimental arthritis was investigated using EC-SOD over-expressing transgenic mice. The over-expression of EC- SOD in joint tissue was confirmed by RT-PCR and immunohistochemistry. The degree of the inflammation in EC-SOD transgenic mice was suppressed in the collagen-induced arthritis model. In a cytokine assay, the production of pro-inflammatory cytokines such as, IL-1β, TNFα, and matrix metalloproteinases (MMPs) was decreased in fibroblast-like synoviocyte (FLS) but not in peripheral blood. Histological examination also showed repressed cartilage destruction and bone in EC-SOD transgenic mice. In conclusion, these data suggest that the over-expression of EC-SOD in FLS contributes to the activation of FLS and protection from joint destruction by depressing the production of the pro-inflammatory cytokines and MMPs. These results provide EC-SOD transgenic mice with a useful animal model for inflammatory arthritis research.
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