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김도경 ( Kim¸ Do-kyoung ) 한국현대문예비평학회 2020 한국문예비평연구 Vol.- No.68
이 논문에서는 1920년대 중반에 발표된 이광수의 「재생」과 방인근, 박종화, 윤귀영 등의 소설 함께 분석하여 자동차 모빌리티가 어떻게 새로운 시공간 체험으로 인물들을 이끌었으며, 또한 이것이 근대소설 텍스트에 어떤 새로운 인식과 정동을 기입하는지를 살펴보았다. 자동차는 사적인 욕구에 유연하게 대응하는 한편, 이를 더욱 촉발시킴으로써 밀실의 모빌리티를 제공하였다. 그런데 밀실의 모빌리티가 창출되는 것은 운전석이 지워짐으로써 비로소 가능한 것이었다. 운전수는 자동차 내 공간을 점유하고 있지만, 자동차 모빌리티에서 소외되는 동시에 비가시화된다. 또한 자동차의 내부에서 차창 너머의 행인들은 자신들의 속도에 방해가 되거나 자신들에게 외부의 시선을 던짐으로써 밀실의 모빌리티를 위협할 수 있는 적대적 존대로 인식되게 되었다. 탑승을 통해 공유하는 공간이 체험되었던 기차와 달리 자동차의 외부에서는 자동차의 내부를 식별할 수 있었다. 가시적으로 목격 가능하되 소유할 수 없는 자동차 모빌리티의 특질은 자동차 외부의 소외감을 더욱 증폭하는 요소가 되기도 하였다. 이처럼 자동차는 기차에 비해 세분된 모빌리티의 체험을 제공했고, 분화되는 모빌리티의 체험은 개인의 경험 세계를 더욱 분절함으로써 공동체에 대한 이전 세대의 상상의 허약성을 환기시켰다. The theme of this paper is how car-mobility leads characters to experiences of new time and space and what the new sense and affections this was in the text of the modern novel. For this purpose, Lee Kwang-soo's [Revival(재생)] were analyzed. Car-mobility has been more responsive to private needs, while further triggering this. The characters exchanged intimate conversations and acts in the moving secret rooms, and the scenery outside the car windows was seen as confronting individual speed and desire. Car-mobility separates the driver's seat from the back seat as well as the outside in the car. The driver occupies space in the car, but at the same time he is alienated from car-mobility, he becomes invisible. It was only possible when the driver's seat was erased that the mobility of the secret room was created. As such, Car-mobility provided a segmented experience of mobility compared to trains, and the differentiated experience of mobility revealed the weakness of the previous generation's imagination of the community by further dividing the individual's experience world.
Segmental nevus spilus treated with combined use of multiple laser therapies
( Dokyoung Yoon ),( Hyun Jeong Byun ),( Chan Seong Park ),( Sewon Park ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Nevus spilus (NS) is characterized by numerous small, darkly pigmented macules or papules on a tan-pigmented background. This lesion is also referred as speckled lentiginous nevus, zosteriform lentiginous nevus, or spotty nevus. Darkly pigmented macules or papules can be a junctional nevus, compound nevus, Spitz nevus, or blue nevus. Treatment for NS has not been established yet and possibilities of developing melanomas in NS require long-term follow-up examinations in patients. Treatment trials with laser modalities have been widely reported as it may seriously affect one’s appearance. A 31-year old man presented with multiple brown-colored macules and papules on left mandible, neck, and chest. The patient previously had skin biopsy on the lesion and the results turned out benign nevus. He was otherwise healthy and eager to receive laser therapy for cosmetic issue. Total 6 sessions of combination of carbon dioxide (CO2) and 532nm Q-switched Nd-YAG (QSND) laser over a year on the dark pigmented macules and papules were conducted, which showed excellent response. For background tan-pigmented lesion, 1927nm tulium fractional laser was applied afterwards or simultaneously. For over 1 year follow up, no recurrences or aggravation of lesion was found. Herein, we report a case of segmental nevus spilus successfully treated with combinations of various laser modalities.
A case of pyoderma gangrenosum in a patient with ulcerative colitis on golimumab and vedolizumab
( Dokyoung Yoon ),( Hyun Jeong Byun ),( Se Jin Oh ),( Sewon Park ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Pyoderma gangrenosum (PG) is a rare infiltrative neutrophilic dermatosis that characteristically presents with painful ulcers with undermined borders. Reports of development of inflammatory diseases, including psoriasis, pyoderma gangrenosum and dermatitis-like skin reactions with anti-tumor necrosis factor-α (TNF-α), are increasing. A 26-year old man presented with painful multiple pustular lesions with ulceration on face, scalp, and both legs for a week. The patient had second injection of Golimumab, which targets TNF-α, for ulcerative colitis 2 days before the skin eruption came up. Biopsy specimen showed diffuse infiltrate of lymphocytes, neutrophils, eosinophils and histiocytes with ulcer and granulation tissue. Laboratory results found that white blood cell count 18.1 x103/μL. Blood culture and skin cultures for bacteria, fungus, and mycobacterium showed no evidence of infection. Together with his clinical presentation, laboratory results, and biopsy, the patient was diagnosed with PG. The patient was treated with methylprednisolone, cefotaxime, and daily dressing change. Golimumab was stopped and the patient switched to Vedolizumab, anti-integrin α4β7 showing gut-selective anti-inflammatory activity. A month later, after his third injection of Vedolizumab, the patient presented with exacerbation of the skin lesion. Herein, we report a case of PG in an ulcerative colitis patient on Golimumab and Vedolizumab respectively.
( Dokyoung Yoon ),( Hyun Jeong Byun ),( Se Jin Oh ),( Ji-hye Park ),( Dong-youn Lee ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.2
Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously. (Ann Dermatol 32(2) 164∼167, 2020)
Affecting factors associated with response of anti-PD-1 therapy in melanoma
( Dokyoung Yoon ),( Donghwi Jang ),( Hyun Jeong Byun ),( Se Jin Oh ),( Youngkyoung Lim ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Anti-PD-1 therapy enhances pre-existing immune responses by directly blocking anti-programmed cell death receptor-1. Objectives: To determine the association between dermatologic side effect(SE) and oncologic response of anti-PD-1therapy and to investigate SEs of anti-PD- 1therapy. Methods: We retrospectively reviewed records on patients with melanoma referred to dermatology for skin lesion after treated with pembrolizumab and nivolumab from January 1st, 2015 to April 30th, 2019. To investigate the association between oncologic outcome and dermatologic SE, patients were divided into two groups; good response (complete remission, partial remission), poor response (stable disease, progressive disease). Results: Of 177 patients screened for the study, 14 patients were referred to dermatology with cutaneous SEs. Dermatologic SE includes acneiform eruption, keratoacanthoma, nail change, pruritic eruption, psoriatic eruption, urticarial eruption, and vitiligo. Mean age of all patients with or without dermatologic SE was 58. Though patients who had dermatologic side effect showed higher proportion in good response than that of patients without dermatologic side effect, it was not statistically significant. Conclusion: Various adverse events can occur after anti PD-1 therapy. Dermatologists are supposed to be aware of side-effect profile of the therapy to make sure prompt diagnosis and adequate management.
Mutations in acral melanoma identified by whole exome sequencing
( Dokyoung Yoon ),( Youngkyoung Lim ),( Dong-youn Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: There is limited research examining the different aspects of genetic alterations between nail apparatus melanoma (NAM) and non-nail acral melanoma (NNAM) Objectives: To uncover previously unidentified novel mutations for the acral melanoma patients and genomic differences between the NAM and the NNAM Methods: We performed whole-exome sequencing on DNA from 31 saliva samples and 31 tumor tissue samples from Korean AM patients pathologically confirmed at Samsung Medical Center (Seoul, Korea) from September 2016 to March 2019. Mutational profiles were compared between NAMs and NNAMs. Results: Prevalence of the detected well-known pathogenic mutations among the primary melanoma samples were BRAF V600E (16.13%), NRAS (9.68%), and KIT (3.23%). We also identified 53 genes that were repeatedly detected in AMs including BRAF, NRAS, CACMA1E, CDC27, CYP4F2, DDX11, and PCMTD1. 19 genes were predicted to be deleterious in developing melanomas including ANGPTL5, BRAF, CSMD3 and EHMT11 among repeatedly detected genes in AMs. Our results revealed several genes such as CSMD3, EHMT1, and MAGI1 were distinct mutations in the NAM. Conclusion: We identified the mutational landscape, genetic alterations, and differences of genetic backgrounds between NAM and NNAM in the Korean population. Because genetic backgrounds are different for NAM and NNAM, it is necessary to approach each disease in a separate way.