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Doh, I.,Kim, Y.,Cho, Y.H. Elsevier 2013 CURRENT APPLIED PHYSICS Vol.13 No.5
We present a high-efficient particle trapping chip, where a wide and uniform slit is formed by a deformable membrane barrier with air bubble plugs. The previous particle trapping methods based on membrane barriers resulted in low trapping efficiency due to the non-uniform slit gap between the membrane and the substrate, especially at the side walls of rectangular channel. In the present method, the air bubble plugs remained in the extended microchannel during sample filling process, block the particle passage at the both side ends of the membrane, thus all particles flow through the uniform slit gap. Therefore, high-efficient particle trapping without particle loss can be achieved. The present particle trapping chip was composed of three layers: pneumatic (top), membrane and channel (bottom) layers. The membrane was deformed by the pneumatic pressure applied from the top layer. In the experimental study using 10.3 μm-diameter polystyrene beads, the membrane barrier with the air bubble plugs successfully trapped the injected beads with the trapping efficiency of 100% at the flow rate of 10 μl/min, while the barrier without the air bubble plugs showed low efficiency of 20%. At the increased flow rate of 20 μl/min, beads were still trapped with trapping efficiency over 98% in the present device. By using a mixture of 5.7 and 10.3 μm-diameter beads, we also verified the present method was capable to trap and release the beads selectively according to their size with the release efficiency of 95.1%. The present simple and effective particle trapping device is applicable for the high-efficient bioparticle isolation and recovery in the micro total analysis system.
A Simulation Study on The Discounted Cost Distribution under Age Replacement Policy
Dohi, Tadashi,Ashioka, Akira,Kaio, Naoto,Osaki, Shunji Korean Institute of Industrial Engineers 2004 Industrial Engineeering & Management Systems Vol.3 No.2
During the last three decades, a few attentions have been paid for investigating the cost distribution for the optimal maintenance problems. In this article, we derive the moment of the discounted cost distribution over an infinite time horizon for the basic age replacement problem. With first two moments of the discounted cost distribution, we approximate the underlying distribution function by three theoretical distributions. Through a Monte Carlo simulation, we conclude that the log-normal distribution is the best fitted one to approximate the discounted cost distribution.
Visualizing the phenotype diversity: a case study of Alexander disease
Dohi, Eisuke,Bangash, Ali Haider Korea Genome Organization 2021 Genomics & informatics Vol.19 No.3
Since only a small number of patients have a rare disease, it is difficult to identify all of the features of these diseases. This is especially true for patients uncommonly presenting with rare diseases. It can also be difficult for the patient, their families, and even clinicians to know which one of a number of disease phenotypes the patient is exhibiting. To address this issue, during Biomedical Linked Annotation Hackathon 7 (BLAH7), we tried to extract Alexander disease patient data in Portable Document Format. We then visualized the phenotypic diversity of those Alexander disease patients with uncommon presentations. This led to us identifying several issues that we need to overcome in our future work.
SINGULAR INTEGRALS ON CERTAIN ORLICZ CLASSES AND ZYGMUND SPACES
KIM, DOHIE,CHO, YONG-KUM,KIM, MIRAN,KOH, DOOWON 中央大學校 基礎科學硏究所 1998 基礎科學硏究所 論文集 Vol.12 No.-
In this paper we consider the original versions of Calderon-Zygmund singular integrals and set up a list of boundedness properties on certain Orlicz classes as wel as Zygmund spaces L log L and ??.